Enhancing anticancer cytotoxicity through bimodal drug delivery from ultrasmall Zr MOF nanoparticles

Dual delivery of dichloroacetate and 5-fluorouracil from Zr MOFs into cancer cells is found to enhance in vitro cytotoxicity. Tuning particle size and, more significantly, surface chemistry, further improves cytotoxicity by promoting caveolae-mediated endocytosis and cytosolic cargo delivery.

Bibliographische Detailangaben

Veröffentlicht in:	Chemical communications (Cambridge, England) England), 2018, Vol.54 (22), p.2792-2795
Hauptverfasser:	Abánades Lázaro, Isabel, Abánades Lázaro, Sandra, Forgan, Ross S
Format:	Artikel
Sprache:	eng
Schlagworte:	Cytotoxicity Drug delivery systems Toxicity Zirconium
Online-Zugang:	Volltext
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