IRAK1 Augments Cancer Stemness and Drug Resistance via the AP-1/AKR1B10 Signaling Cascade in Hepatocellular Carcinoma

Frequent relapse and drug resistance in patients with hepatocellular carcinoma (HCC) can be attributed to the existence of tumor-initiating cells (TIC) within the tumor bulk. Therefore, targeting liver TICs may improve the prognosis of these patients. From transcriptome sequencing of 16 pairs of cli...

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Veröffentlicht in:	Cancer research (Chicago, Ill.) Ill.), 2018-05, Vol.78 (9), p.2332-2342
Hauptverfasser:	Cheng, Bowie Y, Lau, Eunice Y, Leung, Hoi-Wing, Leung, Carmen Oi-Ning, Ho, Nicole P, Gurung, Shilpa, Cheng, Lily K, Lin, Chi Ho, Lo, Regina Cheuk-Lam, Ma, Stephanie, Ng, Irene Oi-Lin, Lee, Terence K
Format:	Artikel
Sprache:	eng
Schlagworte:	Aldo-keto reductase Apoptosis Cell self-renewal Doxorubicin Drug resistance Enzyme inhibitors Gene expression Hepatocellular carcinoma Inhibition Interleukin 1 IRAK protein Kinases Liver Liver cancer Medical prognosis Patients Signal transduction Therapeutic applications Transcription factors Tumorigenicity Xenografts
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