Factors associated with repeat diagnosis of syphilis in genitourinary medicine (GUM) clinic attendees in the North East of England, 2002–2014
This study aimed to identify factors associated with repeat syphilis infection in North East England, in order to inform local prevention and control opportunities. We undertook a case–case study comparing individuals diagnosed with single or multiple episodes of syphilis infection within genitourin...
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| Veröffentlicht in: | International journal of STD & AIDS 2018-07, Vol.29 (8), p.790-799 |
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| creator | Dolan, G Chauhan, M Foster, K Basta, M Bushby, S White, C Verlander, NQ Gorton, R |
| description | This study aimed to identify factors associated with repeat syphilis infection in North East England, in order to inform local prevention and control opportunities. We undertook a case–case study comparing individuals diagnosed with single or multiple episodes of syphilis infection within genitourinary medicine (GUM) clinics in NE England (12 clinics serving a population of 2.5 million). Study cases were verified as having had true re-infection by a GUM clinician (using serological and/or clinical parameters) and control cases (3 per case) frequency matched to cases by age and year of presentation. The odds of exposure to sexual behavioural and clinical factors were compared for cases and control cases using stepwise multivariable logistic regression. We included 66 cases and 235 control cases. The majority of cases (62/66) and control cases (165/235) were men who had sex with men (MSM). Data were missing for 0–64% of cases across different variables. Following multivariable analysis HIV seropositivity (OR 23.3, 95% CI 4.32–125.9), failure to attend follow-up (OR 4.63, 95% CI 1.11–19.31), stage of infection and deprivation were associated with re-infection (p |
| doi_str_mv | 10.1177/0956462418757554 |
| format | Article |
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We undertook a case–case study comparing individuals diagnosed with single or multiple episodes of syphilis infection within genitourinary medicine (GUM) clinics in NE England (12 clinics serving a population of 2.5 million). Study cases were verified as having had true re-infection by a GUM clinician (using serological and/or clinical parameters) and control cases (3 per case) frequency matched to cases by age and year of presentation. The odds of exposure to sexual behavioural and clinical factors were compared for cases and control cases using stepwise multivariable logistic regression. We included 66 cases and 235 control cases. The majority of cases (62/66) and control cases (165/235) were men who had sex with men (MSM). Data were missing for 0–64% of cases across different variables. Following multivariable analysis HIV seropositivity (OR 23.3, 95% CI 4.32–125.9), failure to attend follow-up (OR 4.63, 95% CI 1.11–19.31), stage of infection and deprivation were associated with re-infection (p < 0.001). In this study, HIV seropositivity and failure to attend follow-up were associated with re-infection with syphilis. Actions targeted at these groups may help to reduce ongoing transmission.</description><identifier>ISSN: 0956-4624</identifier><identifier>EISSN: 1758-1052</identifier><identifier>DOI: 10.1177/0956462418757554</identifier><identifier>PMID: 29482448</identifier><language>eng</language><publisher>London, England: SAGE Publications</publisher><subject>Adolescent ; Adult ; AIDS/HIV ; Ambulatory Care Facilities ; Case-Control Studies ; Coinfection - epidemiology ; England - epidemiology ; HIV Infections - epidemiology ; HIV Seropositivity - complications ; HIV Seropositivity - epidemiology ; Humans ; Lost to Follow-Up ; Middle Aged ; Patient Acceptance of Health Care - statistics & numerical data ; Recurrence ; Risk Factors ; Secondary Prevention ; Syphilis - epidemiology ; Syphilis - prevention & control ; Time Factors ; Treatment Outcome</subject><ispartof>International journal of STD & AIDS, 2018-07, Vol.29 (8), p.790-799</ispartof><rights>The Author(s) 2018</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c337t-ac958c37f33c1bd2b50d928c43bc254cf1b3243f10e0114f398b0e737a31378f3</citedby><cites>FETCH-LOGICAL-c337t-ac958c37f33c1bd2b50d928c43bc254cf1b3243f10e0114f398b0e737a31378f3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://journals.sagepub.com/doi/pdf/10.1177/0956462418757554$$EPDF$$P50$$Gsage$$H</linktopdf><linktohtml>$$Uhttps://journals.sagepub.com/doi/10.1177/0956462418757554$$EHTML$$P50$$Gsage$$H</linktohtml><link.rule.ids>314,776,780,21798,27901,27902,43597,43598</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/29482448$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Dolan, G</creatorcontrib><creatorcontrib>Chauhan, M</creatorcontrib><creatorcontrib>Foster, K</creatorcontrib><creatorcontrib>Basta, M</creatorcontrib><creatorcontrib>Bushby, S</creatorcontrib><creatorcontrib>White, C</creatorcontrib><creatorcontrib>Verlander, NQ</creatorcontrib><creatorcontrib>Gorton, R</creatorcontrib><title>Factors associated with repeat diagnosis of syphilis in genitourinary medicine (GUM) clinic attendees in the North East of England, 2002–2014</title><title>International journal of STD & AIDS</title><addtitle>Int J STD AIDS</addtitle><description>This study aimed to identify factors associated with repeat syphilis infection in North East England, in order to inform local prevention and control opportunities. We undertook a case–case study comparing individuals diagnosed with single or multiple episodes of syphilis infection within genitourinary medicine (GUM) clinics in NE England (12 clinics serving a population of 2.5 million). Study cases were verified as having had true re-infection by a GUM clinician (using serological and/or clinical parameters) and control cases (3 per case) frequency matched to cases by age and year of presentation. The odds of exposure to sexual behavioural and clinical factors were compared for cases and control cases using stepwise multivariable logistic regression. We included 66 cases and 235 control cases. The majority of cases (62/66) and control cases (165/235) were men who had sex with men (MSM). Data were missing for 0–64% of cases across different variables. Following multivariable analysis HIV seropositivity (OR 23.3, 95% CI 4.32–125.9), failure to attend follow-up (OR 4.63, 95% CI 1.11–19.31), stage of infection and deprivation were associated with re-infection (p < 0.001). In this study, HIV seropositivity and failure to attend follow-up were associated with re-infection with syphilis. Actions targeted at these groups may help to reduce ongoing transmission.</description><subject>Adolescent</subject><subject>Adult</subject><subject>AIDS/HIV</subject><subject>Ambulatory Care Facilities</subject><subject>Case-Control Studies</subject><subject>Coinfection - epidemiology</subject><subject>England - epidemiology</subject><subject>HIV Infections - epidemiology</subject><subject>HIV Seropositivity - complications</subject><subject>HIV Seropositivity - epidemiology</subject><subject>Humans</subject><subject>Lost to Follow-Up</subject><subject>Middle Aged</subject><subject>Patient Acceptance of Health Care - statistics & numerical data</subject><subject>Recurrence</subject><subject>Risk Factors</subject><subject>Secondary Prevention</subject><subject>Syphilis - epidemiology</subject><subject>Syphilis - prevention & control</subject><subject>Time Factors</subject><subject>Treatment Outcome</subject><issn>0956-4624</issn><issn>1758-1052</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2018</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp1kbtOJDEQRS20CIZHTrRyCBINfo7dIULDQ-KRQNxyu6tnjHrswfZoRbZ_QMAf8iV4GNgAaaMqqe49qrqF0AElJ5QqdUpqORZjJqhWUkkpNtCIKqkrSiT7hUarcbWab6OdlJ4IIWOu6i20zWqhmRB6hF4vjM0hJmxSCtaZDB3-4_IMR1iAybhzZupDcgmHHqeXxcwNpXceT8G7HJbReRNf8Bw6Z50HfHj5eHuE7eC8s9jkDL4D-DTkGeC7EAt6YlJe4SZ-OhjfHWNGCHv_-8YIFXtoszdDgv2vuoseLyYP51fVzf3l9fnZTWU5V7kytpbactVzbmnbsVaSrmbaCt5aJoXtacuZ4D0lQCgVPa91S0BxZTjlSvd8Fx2uuYsYnpeQcjN3ycJQFoKwTE1ZSWs9pkIVKVlLbQwpReibRXTzcnVDSbN6Q_PzDcXy-4u-bEs0_wzfuRdBtRYkM4XmqeToy7X_B34AX9OPoA</recordid><startdate>201807</startdate><enddate>201807</enddate><creator>Dolan, G</creator><creator>Chauhan, M</creator><creator>Foster, K</creator><creator>Basta, M</creator><creator>Bushby, S</creator><creator>White, C</creator><creator>Verlander, NQ</creator><creator>Gorton, R</creator><general>SAGE Publications</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>201807</creationdate><title>Factors associated with repeat diagnosis of syphilis in genitourinary medicine (GUM) clinic attendees in the North East of England, 2002–2014</title><author>Dolan, G ; Chauhan, M ; Foster, K ; Basta, M ; Bushby, S ; White, C ; Verlander, NQ ; Gorton, R</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c337t-ac958c37f33c1bd2b50d928c43bc254cf1b3243f10e0114f398b0e737a31378f3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2018</creationdate><topic>Adolescent</topic><topic>Adult</topic><topic>AIDS/HIV</topic><topic>Ambulatory Care Facilities</topic><topic>Case-Control Studies</topic><topic>Coinfection - epidemiology</topic><topic>England - epidemiology</topic><topic>HIV Infections - epidemiology</topic><topic>HIV Seropositivity - complications</topic><topic>HIV Seropositivity - epidemiology</topic><topic>Humans</topic><topic>Lost to Follow-Up</topic><topic>Middle Aged</topic><topic>Patient Acceptance of Health Care - statistics & numerical data</topic><topic>Recurrence</topic><topic>Risk Factors</topic><topic>Secondary Prevention</topic><topic>Syphilis - epidemiology</topic><topic>Syphilis - prevention & control</topic><topic>Time Factors</topic><topic>Treatment Outcome</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Dolan, G</creatorcontrib><creatorcontrib>Chauhan, M</creatorcontrib><creatorcontrib>Foster, K</creatorcontrib><creatorcontrib>Basta, M</creatorcontrib><creatorcontrib>Bushby, S</creatorcontrib><creatorcontrib>White, C</creatorcontrib><creatorcontrib>Verlander, NQ</creatorcontrib><creatorcontrib>Gorton, R</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>International journal of STD & AIDS</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Dolan, G</au><au>Chauhan, M</au><au>Foster, K</au><au>Basta, M</au><au>Bushby, S</au><au>White, C</au><au>Verlander, NQ</au><au>Gorton, R</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Factors associated with repeat diagnosis of syphilis in genitourinary medicine (GUM) clinic attendees in the North East of England, 2002–2014</atitle><jtitle>International journal of STD & AIDS</jtitle><addtitle>Int J STD AIDS</addtitle><date>2018-07</date><risdate>2018</risdate><volume>29</volume><issue>8</issue><spage>790</spage><epage>799</epage><pages>790-799</pages><issn>0956-4624</issn><eissn>1758-1052</eissn><abstract>This study aimed to identify factors associated with repeat syphilis infection in North East England, in order to inform local prevention and control opportunities. We undertook a case–case study comparing individuals diagnosed with single or multiple episodes of syphilis infection within genitourinary medicine (GUM) clinics in NE England (12 clinics serving a population of 2.5 million). Study cases were verified as having had true re-infection by a GUM clinician (using serological and/or clinical parameters) and control cases (3 per case) frequency matched to cases by age and year of presentation. The odds of exposure to sexual behavioural and clinical factors were compared for cases and control cases using stepwise multivariable logistic regression. We included 66 cases and 235 control cases. The majority of cases (62/66) and control cases (165/235) were men who had sex with men (MSM). Data were missing for 0–64% of cases across different variables. Following multivariable analysis HIV seropositivity (OR 23.3, 95% CI 4.32–125.9), failure to attend follow-up (OR 4.63, 95% CI 1.11–19.31), stage of infection and deprivation were associated with re-infection (p < 0.001). In this study, HIV seropositivity and failure to attend follow-up were associated with re-infection with syphilis. Actions targeted at these groups may help to reduce ongoing transmission.</abstract><cop>London, England</cop><pub>SAGE Publications</pub><pmid>29482448</pmid><doi>10.1177/0956462418757554</doi><tpages>10</tpages></addata></record> |
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| subjects | Adolescent Adult AIDS/HIV Ambulatory Care Facilities Case-Control Studies Coinfection - epidemiology England - epidemiology HIV Infections - epidemiology HIV Seropositivity - complications HIV Seropositivity - epidemiology Humans Lost to Follow-Up Middle Aged Patient Acceptance of Health Care - statistics & numerical data Recurrence Risk Factors Secondary Prevention Syphilis - epidemiology Syphilis - prevention & control Time Factors Treatment Outcome |
| title | Factors associated with repeat diagnosis of syphilis in genitourinary medicine (GUM) clinic attendees in the North East of England, 2002–2014 |
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