MCT4 Expression Is a Potential Therapeutic Target in Colorectal Cancer with Peritoneal Carcinomatosis

Monocarboxylate transporters (MCT) are transmembrane proteins that control the lactate metabolism and are associated with poor prognosis in solid tumors, including colorectal cancer. Here, we aimed to investigate the biological and clinical role of MCTs in colorectal cancer and to assess the potenti...

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Veröffentlicht in:	Molecular cancer therapeutics 2018-04, Vol.17 (4), p.838-848
Hauptverfasser:	Kim, Hee Kyung, Lee, InKyoung, Bang, Heejin, Kim, Hee Cheol, Lee, Woo Yong, Yun, Seong Hyeon, Lee, Jeeyun, Lee, Su Jin, Park, Young Suk, Kim, Kyoung-Mee, Kang, Won Ki
Format:	Artikel
Sprache:	eng
Schlagworte:	Adenocarcinoma - genetics Adenocarcinoma - metabolism Adenocarcinoma - secondary Adenocarcinoma, Mucinous - genetics Adenocarcinoma, Mucinous - metabolism Adenocarcinoma, Mucinous - secondary Adult Aged Aged, 80 and over Angiogenesis Animal models Animals Apoptosis Ascites Biomarkers, Tumor - genetics Biomarkers, Tumor - metabolism Biotechnology Cancer Carcinoma, Signet Ring Cell - genetics Carcinoma, Signet Ring Cell - metabolism Carcinoma, Signet Ring Cell - secondary Cell Proliferation Chemotherapy Colorectal cancer Colorectal carcinoma Colorectal Neoplasms - genetics Colorectal Neoplasms - metabolism Colorectal Neoplasms - pathology Combined treatment Female Follow-Up Studies Humans Hypoxia Hypoxia-inducible factor 1 Hypoxia-inducible factor 1a In vivo methods and tests Inhibition Lactic acid Male Medical prognosis Membrane proteins Metabolism Mice Mice, Inbred BALB C Mice, Nude Middle Aged Monocarboxylic Acid Transporters - genetics Monocarboxylic Acid Transporters - metabolism Muscle Proteins - genetics Muscle Proteins - metabolism Neoplasm Invasiveness Patients Peritoneal Neoplasms - genetics Peritoneal Neoplasms - metabolism Peritoneal Neoplasms - secondary Peritoneum Prognosis Proteins Radiation therapy siRNA Solid tumors Surgery Survival Survival analysis Survival Rate Therapeutic applications Tissues Tumor cell lines Tumor Cells, Cultured Tumors Xenograft Model Antitumor Assays Xenografts Xenotransplantation
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