Histone deacetylase-1 and -3 protein expression in human breast cancer: a tissue microarray analysis
Impaired histone acetylation was recognized to be involved in carcinogenesis. Furthermore, histone deacetylase (HDAC) inhibitors induce differentiation of breast cancer cells and inhibit tumour growth. These results prompted us to study HDAC-1 and -3 expression in breast tumours to establish their p...
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| Veröffentlicht in: | Breast cancer research and treatment 2005-03, Vol.90 (1), p.15-23 |
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| creator | KRUSCHE, Claudia A WÜLFING, Pia KERSTING, Christian VLOET, Anne BÖCKER, Werner KIESEL, Ludwig BEIER, Henning M ALFER, Joachim |
| description | Impaired histone acetylation was recognized to be involved in carcinogenesis. Furthermore, histone deacetylase (HDAC) inhibitors induce differentiation of breast cancer cells and inhibit tumour growth. These results prompted us to study HDAC-1 and -3 expression in breast tumours to establish their potential therapeutic and prognostic significance. HDAC-1 und HDAC-3 protein expression was analyzed immunohistochemically on a tissue microarray (TMA) containing 600 core biopsies from 200 patients. HDAC-1 and -3 expression was correlated to steroid hormone receptor-, Her2/neu- and proliferation status of tumours as well as to overall and disease free survival. Moderate or strong nuclear immunoreactivity for HDAC-1 was observed in 39.8% and for HDAC-3 in 43.9% of breast carcinomas. HDAC-1 and -3 expression correlated significantly with oestrogen and progesterone receptor expression (both p< 0.001). HDAC-1 expression predicted significantly better disease free survival (DFS: p=0.044), in particular, in patients with small tumours of all differentiation types (DFS: p=0.016). Multivariate analysis demonstrated that HDAC-1 is an independent prognostic marker. Our data suggest that evaluation of HDAC-1 protein expression enables a more precise assessment of the prognosis of breast cancer patients. Thus, HDAC-1 expression analysis might be clinically useful to facilitate an individual, risk-directed, adjuvant systemic therapy in breast cancer patients. |
| doi_str_mv | 10.1007/s10549-004-1668-2 |
| format | Article |
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Furthermore, histone deacetylase (HDAC) inhibitors induce differentiation of breast cancer cells and inhibit tumour growth. These results prompted us to study HDAC-1 and -3 expression in breast tumours to establish their potential therapeutic and prognostic significance. HDAC-1 und HDAC-3 protein expression was analyzed immunohistochemically on a tissue microarray (TMA) containing 600 core biopsies from 200 patients. HDAC-1 and -3 expression was correlated to steroid hormone receptor-, Her2/neu- and proliferation status of tumours as well as to overall and disease free survival. Moderate or strong nuclear immunoreactivity for HDAC-1 was observed in 39.8% and for HDAC-3 in 43.9% of breast carcinomas. HDAC-1 and -3 expression correlated significantly with oestrogen and progesterone receptor expression (both p< 0.001). HDAC-1 expression predicted significantly better disease free survival (DFS: p=0.044), in particular, in patients with small tumours of all differentiation types (DFS: p=0.016). Multivariate analysis demonstrated that HDAC-1 is an independent prognostic marker. Our data suggest that evaluation of HDAC-1 protein expression enables a more precise assessment of the prognosis of breast cancer patients. Thus, HDAC-1 expression analysis might be clinically useful to facilitate an individual, risk-directed, adjuvant systemic therapy in breast cancer patients.</description><identifier>ISSN: 0167-6806</identifier><identifier>EISSN: 1573-7217</identifier><identifier>DOI: 10.1007/s10549-004-1668-2</identifier><identifier>PMID: 15770522</identifier><identifier>CODEN: BCTRD6</identifier><language>eng</language><publisher>Dordrecht: Springer</publisher><subject>Biological and medical sciences ; Biomarkers, Tumor - metabolism ; Breast cancer ; Breast Neoplasms - mortality ; Breast Neoplasms - pathology ; Cancer research ; Cell Differentiation ; Disease-Free Survival ; Female ; Follow-Up Studies ; Gene expression ; Germany - epidemiology ; Gynecology. Andrology. Obstetrics ; Histone Deacetylases - metabolism ; Humans ; Immunohistochemistry ; Mammary gland diseases ; Medical sciences ; Medical treatment ; Middle Aged ; Proportional Hazards Models ; Proteins ; Survival Rate ; Tissue Array Analysis ; Tumors</subject><ispartof>Breast cancer research and treatment, 2005-03, Vol.90 (1), p.15-23</ispartof><rights>2005 INIST-CNRS</rights><rights>Springer 2005</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c422t-75e3a844f242bf3a3d7944e53b33d34624ed84fdabe6c2e1dc5433bbd00422c73</citedby><cites>FETCH-LOGICAL-c422t-75e3a844f242bf3a3d7944e53b33d34624ed84fdabe6c2e1dc5433bbd00422c73</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,776,780,27901,27902</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=16638122$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/15770522$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>KRUSCHE, Claudia A</creatorcontrib><creatorcontrib>WÜLFING, Pia</creatorcontrib><creatorcontrib>KERSTING, Christian</creatorcontrib><creatorcontrib>VLOET, Anne</creatorcontrib><creatorcontrib>BÖCKER, Werner</creatorcontrib><creatorcontrib>KIESEL, Ludwig</creatorcontrib><creatorcontrib>BEIER, Henning M</creatorcontrib><creatorcontrib>ALFER, Joachim</creatorcontrib><title>Histone deacetylase-1 and -3 protein expression in human breast cancer: a tissue microarray analysis</title><title>Breast cancer research and treatment</title><addtitle>Breast Cancer Res Treat</addtitle><description>Impaired histone acetylation was recognized to be involved in carcinogenesis. Furthermore, histone deacetylase (HDAC) inhibitors induce differentiation of breast cancer cells and inhibit tumour growth. These results prompted us to study HDAC-1 and -3 expression in breast tumours to establish their potential therapeutic and prognostic significance. HDAC-1 und HDAC-3 protein expression was analyzed immunohistochemically on a tissue microarray (TMA) containing 600 core biopsies from 200 patients. HDAC-1 and -3 expression was correlated to steroid hormone receptor-, Her2/neu- and proliferation status of tumours as well as to overall and disease free survival. Moderate or strong nuclear immunoreactivity for HDAC-1 was observed in 39.8% and for HDAC-3 in 43.9% of breast carcinomas. HDAC-1 and -3 expression correlated significantly with oestrogen and progesterone receptor expression (both p< 0.001). HDAC-1 expression predicted significantly better disease free survival (DFS: p=0.044), in particular, in patients with small tumours of all differentiation types (DFS: p=0.016). Multivariate analysis demonstrated that HDAC-1 is an independent prognostic marker. Our data suggest that evaluation of HDAC-1 protein expression enables a more precise assessment of the prognosis of breast cancer patients. Thus, HDAC-1 expression analysis might be clinically useful to facilitate an individual, risk-directed, adjuvant systemic therapy in breast cancer patients.</description><subject>Biological and medical sciences</subject><subject>Biomarkers, Tumor - metabolism</subject><subject>Breast cancer</subject><subject>Breast Neoplasms - mortality</subject><subject>Breast Neoplasms - pathology</subject><subject>Cancer research</subject><subject>Cell Differentiation</subject><subject>Disease-Free Survival</subject><subject>Female</subject><subject>Follow-Up Studies</subject><subject>Gene expression</subject><subject>Germany - epidemiology</subject><subject>Gynecology. Andrology. Obstetrics</subject><subject>Histone Deacetylases - metabolism</subject><subject>Humans</subject><subject>Immunohistochemistry</subject><subject>Mammary gland diseases</subject><subject>Medical sciences</subject><subject>Medical treatment</subject><subject>Middle Aged</subject><subject>Proportional Hazards Models</subject><subject>Proteins</subject><subject>Survival Rate</subject><subject>Tissue Array Analysis</subject><subject>Tumors</subject><issn>0167-6806</issn><issn>1573-7217</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2005</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><sourceid>8G5</sourceid><sourceid>BENPR</sourceid><sourceid>GUQSH</sourceid><sourceid>M2O</sourceid><recordid>eNpdkE1rHDEMhk1oabZJf0AvxRTamxt_jT3TWwltUwj00pyNxtYQh_nYWDOQ_fdx2IVAT0Lw6JX0MPZRyW9KSn9FSja2E1JaoZxrhT5jO9V4I7xW_g3bSeW8cK105-w90YOUsvOye8fOK-Rlo_WOpZtM6zIjTwgR18MIhEJxmBMXhu_LsmKeOT7tCxLlZea1u98mmHlfEGjlEeaI5TsHvmaiDfmUY1mgFDjUFBgPlOmSvR1gJPxwqhfs7tfPf9c34vbv7z_XP25FtFqvwjdooLV20Fb3gwGTfGctNqY3JhnrtMXU2iFBjy5qVCk21pi-T1WA1tGbC_b1mFvvftyQ1jBlijiOMOOyUdBStl51XQU__wc-LFup11ZGaWuNbk2F1BGq_xAVHMK-5AnKISgZXvyHo_9Q14cX_0HXmU-n4K2fML1OnIRX4MsJAIowDqXqy_TKOWdaVblnWh2NGQ</recordid><startdate>20050301</startdate><enddate>20050301</enddate><creator>KRUSCHE, Claudia A</creator><creator>WÜLFING, Pia</creator><creator>KERSTING, Christian</creator><creator>VLOET, Anne</creator><creator>BÖCKER, Werner</creator><creator>KIESEL, Ludwig</creator><creator>BEIER, Henning M</creator><creator>ALFER, Joachim</creator><general>Springer</general><general>Springer Nature B.V</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7TO</scope><scope>7X7</scope><scope>7XB</scope><scope>88E</scope><scope>8AO</scope><scope>8C1</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>8G5</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>AZQEC</scope><scope>BENPR</scope><scope>CCPQU</scope><scope>DWQXO</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>GNUQQ</scope><scope>GUQSH</scope><scope>H94</scope><scope>K9-</scope><scope>K9.</scope><scope>M0R</scope><scope>M0S</scope><scope>M1P</scope><scope>M2O</scope><scope>MBDVC</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>Q9U</scope><scope>7QO</scope><scope>7TM</scope><scope>8FD</scope><scope>FR3</scope><scope>P64</scope></search><sort><creationdate>20050301</creationdate><title>Histone deacetylase-1 and -3 protein expression in human breast cancer: a tissue microarray analysis</title><author>KRUSCHE, Claudia A ; WÜLFING, Pia ; KERSTING, Christian ; VLOET, Anne ; BÖCKER, Werner ; KIESEL, Ludwig ; BEIER, Henning M ; ALFER, Joachim</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c422t-75e3a844f242bf3a3d7944e53b33d34624ed84fdabe6c2e1dc5433bbd00422c73</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2005</creationdate><topic>Biological and medical sciences</topic><topic>Biomarkers, Tumor - metabolism</topic><topic>Breast cancer</topic><topic>Breast Neoplasms - mortality</topic><topic>Breast Neoplasms - pathology</topic><topic>Cancer research</topic><topic>Cell Differentiation</topic><topic>Disease-Free Survival</topic><topic>Female</topic><topic>Follow-Up Studies</topic><topic>Gene expression</topic><topic>Germany - epidemiology</topic><topic>Gynecology. Andrology. Obstetrics</topic><topic>Histone Deacetylases - metabolism</topic><topic>Humans</topic><topic>Immunohistochemistry</topic><topic>Mammary gland diseases</topic><topic>Medical sciences</topic><topic>Medical treatment</topic><topic>Middle Aged</topic><topic>Proportional Hazards Models</topic><topic>Proteins</topic><topic>Survival Rate</topic><topic>Tissue Array Analysis</topic><topic>Tumors</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>KRUSCHE, Claudia A</creatorcontrib><creatorcontrib>WÜLFING, Pia</creatorcontrib><creatorcontrib>KERSTING, Christian</creatorcontrib><creatorcontrib>VLOET, Anne</creatorcontrib><creatorcontrib>BÖCKER, Werner</creatorcontrib><creatorcontrib>KIESEL, Ludwig</creatorcontrib><creatorcontrib>BEIER, Henning M</creatorcontrib><creatorcontrib>ALFER, Joachim</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Central (Corporate)</collection><collection>Oncogenes and Growth Factors Abstracts</collection><collection>Health & Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Medical Database (Alumni Edition)</collection><collection>ProQuest Pharma Collection</collection><collection>Public Health Database</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>Research Library (Alumni Edition)</collection><collection>ProQuest Central (Alumni Edition)</collection><collection>ProQuest Central UK/Ireland</collection><collection>ProQuest Central Essentials</collection><collection>ProQuest Central</collection><collection>ProQuest One Community College</collection><collection>ProQuest Central Korea</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>ProQuest Central Student</collection><collection>Research Library Prep</collection><collection>AIDS and Cancer Research Abstracts</collection><collection>Consumer Health Database (Alumni Edition)</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Consumer Health Database</collection><collection>Health & Medical Collection (Alumni Edition)</collection><collection>Medical Database</collection><collection>Research Library</collection><collection>Research Library (Corporate)</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>ProQuest Central Basic</collection><collection>Biotechnology Research Abstracts</collection><collection>Nucleic Acids Abstracts</collection><collection>Technology Research Database</collection><collection>Engineering Research Database</collection><collection>Biotechnology and BioEngineering Abstracts</collection><jtitle>Breast cancer research and treatment</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>KRUSCHE, Claudia A</au><au>WÜLFING, Pia</au><au>KERSTING, Christian</au><au>VLOET, Anne</au><au>BÖCKER, Werner</au><au>KIESEL, Ludwig</au><au>BEIER, Henning M</au><au>ALFER, Joachim</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Histone deacetylase-1 and -3 protein expression in human breast cancer: a tissue microarray analysis</atitle><jtitle>Breast cancer research and treatment</jtitle><addtitle>Breast Cancer Res Treat</addtitle><date>2005-03-01</date><risdate>2005</risdate><volume>90</volume><issue>1</issue><spage>15</spage><epage>23</epage><pages>15-23</pages><issn>0167-6806</issn><eissn>1573-7217</eissn><coden>BCTRD6</coden><abstract>Impaired histone acetylation was recognized to be involved in carcinogenesis. Furthermore, histone deacetylase (HDAC) inhibitors induce differentiation of breast cancer cells and inhibit tumour growth. These results prompted us to study HDAC-1 and -3 expression in breast tumours to establish their potential therapeutic and prognostic significance. HDAC-1 und HDAC-3 protein expression was analyzed immunohistochemically on a tissue microarray (TMA) containing 600 core biopsies from 200 patients. HDAC-1 and -3 expression was correlated to steroid hormone receptor-, Her2/neu- and proliferation status of tumours as well as to overall and disease free survival. Moderate or strong nuclear immunoreactivity for HDAC-1 was observed in 39.8% and for HDAC-3 in 43.9% of breast carcinomas. HDAC-1 and -3 expression correlated significantly with oestrogen and progesterone receptor expression (both p< 0.001). HDAC-1 expression predicted significantly better disease free survival (DFS: p=0.044), in particular, in patients with small tumours of all differentiation types (DFS: p=0.016). Multivariate analysis demonstrated that HDAC-1 is an independent prognostic marker. Our data suggest that evaluation of HDAC-1 protein expression enables a more precise assessment of the prognosis of breast cancer patients. Thus, HDAC-1 expression analysis might be clinically useful to facilitate an individual, risk-directed, adjuvant systemic therapy in breast cancer patients.</abstract><cop>Dordrecht</cop><pub>Springer</pub><pmid>15770522</pmid><doi>10.1007/s10549-004-1668-2</doi><tpages>9</tpages></addata></record> |
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| subjects | Biological and medical sciences Biomarkers, Tumor - metabolism Breast cancer Breast Neoplasms - mortality Breast Neoplasms - pathology Cancer research Cell Differentiation Disease-Free Survival Female Follow-Up Studies Gene expression Germany - epidemiology Gynecology. Andrology. Obstetrics Histone Deacetylases - metabolism Humans Immunohistochemistry Mammary gland diseases Medical sciences Medical treatment Middle Aged Proportional Hazards Models Proteins Survival Rate Tissue Array Analysis Tumors |
| title | Histone deacetylase-1 and -3 protein expression in human breast cancer: a tissue microarray analysis |
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