$Targeting CpG DNA to screen and isolate anti-sepsis fraction and monomers from traditional Chinese herbs using affinity biosensor technology$

Targeting CpG DNA to screen and isolate anti-sepsis fraction and monomers from traditional Chinese herbs using affinity biosensor technology

Bacterial DNA/CpG DNA is recognized as a key molecule during the pathogenesis of sepsis. Therefore, preventing CpG DNA from binding to its receptor is considered as the most promising strategy. In the present experiments, Radix et Rhizoma Rhei had the highest CpG DNA-binding ability among the sevent...

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Veröffentlicht in:	International immunopharmacology 2009-08, Vol.9 (9), p.1021-1031
Hauptverfasser:	Liu, Xin, Cheng, Juan, Zheng, Xinchuang, Chen, Yiguo, Wu, Chong, Li, Bin, Fu, Jianfeng, Cao, Hongwei, Lu, Yongling, Li, Jun, Zheng, Jiang, Zhou, Hong
Format:	Artikel
Sprache:	eng
Schlagworte:	Aconitum - immunology Affinity biosensor Animals Anthraquinones - pharmacology Biological and medical sciences Biosensing Techniques Cell Line Chemical Fractionation Chromatography, High Pressure Liquid CpG DNA CpG Islands - genetics DNA, Bacterial - chemistry DNA, Bacterial - immunology DNA, Bacterial - metabolism Drug Evaluation, Preclinical Drug Synergism Drugs, Chinese Herbal - pharmacology Drugs, Chinese Herbal - therapeutic use Emodin - pharmacology Enzyme Inhibitors - pharmacology Escherichia coli Escherichia coli - immunology Escherichia coli Infections - drug therapy Escherichia coli Infections - genetics Escherichia coli Infections - immunology Female Gene Expression Regulation - drug effects Gene Expression Regulation - immunology Immunity, Innate - drug effects Lipid A - immunology Lipid A - metabolism Macrophages - drug effects Macrophages - immunology Macrophages - metabolism Macrophages - pathology Medical sciences Mice Mice, Inbred Strains Pharmacology. Drug treatments Phytotherapy Protein Binding RadixetRhizomaRhei Rhein Sepsis Sepsis - drug therapy Sepsis - genetics Sepsis - immunology Toll-Like Receptor 9 - genetics Toll-Like Receptor 9 - immunology Toll-Like Receptor 9 - metabolism Traditional Chinese herbs Tumor Necrosis Factor-alpha - immunology Tumor Necrosis Factor-alpha - metabolism
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