Comparative study of fractional CO2 laser and fractional CO2 laser-assisted drug delivery of topical steroid and topical vitamin C in macular amyloidosis
Macular amyloidosis (MA) represents a common variant of primary localized cutaneous amyloidosis. It has a characteristic female predominance; none of the treatment modalities described is either curative or uniformly effective in patients with macular amyloidosis. To determine the effect of fraction...
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| Veröffentlicht in: | Lasers in medical science 2018-05, Vol.33 (4), p.909-916 |
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| creator | Sobhi, Rehab Mohamed Sharaoui, Iman El Nabarawy, Eman Ahmad El Nemr Esmail, Reham Shehab Hegazy, Rehab Aly Aref, Dina Hesham Fouad |
| description | Macular amyloidosis (MA) represents a common variant of primary localized cutaneous amyloidosis. It has a characteristic female predominance; none of the treatment modalities described is either curative or uniformly effective in patients with macular amyloidosis. To determine the effect of fractional CO
2
laser in macular amyloidosis in comparison to fractional CO
2
laser-assisted drug delivery of topical steroids and topical vitamin C, the study includes 10 female patients with cutaneous macular amyloidosis aged between 20 and 62 years. Patients were treated with four sessions of fractional CO
2
laser with 4 weeks interval. Laser treatments were performed using fractional CO
2
laser with the following parameters (power 18 W, spacing 800 μm, dwell time 600 μs, stacking 3). The lesion is divided into three areas: area 1, treated by fractional laser only; area 2, treated by fractional laser followed by topical corticosteroid application under occlusion for 24 h; and area 3, treated by fractional laser followed by topical vitamin C serum application under occlusion for 24 h. All lesions were examined clinically and histologically before the therapy and 1 month after the end of the therapy to evaluate the degree of improvement. All treated areas show significant decrease in pigmentation score after treatment, significant drop in rippling (
P
value |
| doi_str_mv | 10.1007/s10103-018-2457-1 |
| format | Article |
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2
laser in macular amyloidosis in comparison to fractional CO
2
laser-assisted drug delivery of topical steroids and topical vitamin C, the study includes 10 female patients with cutaneous macular amyloidosis aged between 20 and 62 years. Patients were treated with four sessions of fractional CO
2
laser with 4 weeks interval. Laser treatments were performed using fractional CO
2
laser with the following parameters (power 18 W, spacing 800 μm, dwell time 600 μs, stacking 3). The lesion is divided into three areas: area 1, treated by fractional laser only; area 2, treated by fractional laser followed by topical corticosteroid application under occlusion for 24 h; and area 3, treated by fractional laser followed by topical vitamin C serum application under occlusion for 24 h. All lesions were examined clinically and histologically before the therapy and 1 month after the end of the therapy to evaluate the degree of improvement. All treated areas show significant decrease in pigmentation score after treatment, significant drop in rippling (
P
value < 0.016), and improvement of lichenification; as regards the histological improvement, there was a significant decrease of the amyloid amount after treatment. As regards the amyloid amount, results show significant decrease in the amount of amyloid in all of the three treated areas. Area 2 reported the highest decrease in the amyloid amount followed by areas 1 and 3. One patient (10%) was highly satisfied by the treatment, 6 (60%) reported moderate degree of satisfaction, while only 3 (30%) reported mild satisfaction. Minimal complication occurred in the form of post-inflammatory hyperpigmentation in 1 patient. None of the patients suffered pain, ulceration, or infection. Fractional CO
2
alone can be used to improve the texture of macular amyloidosis. If used to assist the delivery of topical steroids and topical vitamin C, improvement can be highly increased.</description><identifier>ISSN: 0268-8921</identifier><identifier>EISSN: 1435-604X</identifier><identifier>DOI: 10.1007/s10103-018-2457-1</identifier><language>eng</language><publisher>London: Springer London</publisher><subject>Amyloidosis ; Ascorbic acid ; Carbon dioxide ; Carbon dioxide lasers ; Clinical outcomes ; Comparative studies ; Corticosteroids ; Dentistry ; Drug delivery ; Drug delivery systems ; Dwell time ; Hyperpigmentation ; Inflammation ; Lasers ; Lesions ; Medicine ; Medicine & Public Health ; Occlusion ; Optical Devices ; Optics ; Pain ; Patients ; Photonics ; Pigmentation ; Quantum Optics ; Review Article ; Steroid hormones ; Steroids ; Therapy ; Vitamin C</subject><ispartof>Lasers in medical science, 2018-05, Vol.33 (4), p.909-916</ispartof><rights>Springer-Verlag London Ltd., part of Springer Nature 2018</rights><rights>Lasers in Medical Science is a copyright of Springer, (2018). All Rights Reserved.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c349t-87d317fea3afc1edad9d49b7096371f77eb032b35fb9f4f6464fe032b40971d13</citedby><cites>FETCH-LOGICAL-c349t-87d317fea3afc1edad9d49b7096371f77eb032b35fb9f4f6464fe032b40971d13</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://link.springer.com/content/pdf/10.1007/s10103-018-2457-1$$EPDF$$P50$$Gspringer$$H</linktopdf><linktohtml>$$Uhttps://link.springer.com/10.1007/s10103-018-2457-1$$EHTML$$P50$$Gspringer$$H</linktohtml><link.rule.ids>314,780,784,27924,27925,41488,42557,51319</link.rule.ids></links><search><creatorcontrib>Sobhi, Rehab Mohamed</creatorcontrib><creatorcontrib>Sharaoui, Iman</creatorcontrib><creatorcontrib>El Nabarawy, Eman Ahmad</creatorcontrib><creatorcontrib>El Nemr Esmail, Reham Shehab</creatorcontrib><creatorcontrib>Hegazy, Rehab Aly</creatorcontrib><creatorcontrib>Aref, Dina Hesham Fouad</creatorcontrib><title>Comparative study of fractional CO2 laser and fractional CO2 laser-assisted drug delivery of topical steroid and topical vitamin C in macular amyloidosis</title><title>Lasers in medical science</title><addtitle>Lasers Med Sci</addtitle><description>Macular amyloidosis (MA) represents a common variant of primary localized cutaneous amyloidosis. It has a characteristic female predominance; none of the treatment modalities described is either curative or uniformly effective in patients with macular amyloidosis. To determine the effect of fractional CO
2
laser in macular amyloidosis in comparison to fractional CO
2
laser-assisted drug delivery of topical steroids and topical vitamin C, the study includes 10 female patients with cutaneous macular amyloidosis aged between 20 and 62 years. Patients were treated with four sessions of fractional CO
2
laser with 4 weeks interval. Laser treatments were performed using fractional CO
2
laser with the following parameters (power 18 W, spacing 800 μm, dwell time 600 μs, stacking 3). The lesion is divided into three areas: area 1, treated by fractional laser only; area 2, treated by fractional laser followed by topical corticosteroid application under occlusion for 24 h; and area 3, treated by fractional laser followed by topical vitamin C serum application under occlusion for 24 h. All lesions were examined clinically and histologically before the therapy and 1 month after the end of the therapy to evaluate the degree of improvement. All treated areas show significant decrease in pigmentation score after treatment, significant drop in rippling (
P
value < 0.016), and improvement of lichenification; as regards the histological improvement, there was a significant decrease of the amyloid amount after treatment. As regards the amyloid amount, results show significant decrease in the amount of amyloid in all of the three treated areas. Area 2 reported the highest decrease in the amyloid amount followed by areas 1 and 3. One patient (10%) was highly satisfied by the treatment, 6 (60%) reported moderate degree of satisfaction, while only 3 (30%) reported mild satisfaction. Minimal complication occurred in the form of post-inflammatory hyperpigmentation in 1 patient. None of the patients suffered pain, ulceration, or infection. Fractional CO
2
alone can be used to improve the texture of macular amyloidosis. If used to assist the delivery of topical steroids and topical vitamin C, improvement can be highly increased.</description><subject>Amyloidosis</subject><subject>Ascorbic acid</subject><subject>Carbon dioxide</subject><subject>Carbon dioxide lasers</subject><subject>Clinical outcomes</subject><subject>Comparative studies</subject><subject>Corticosteroids</subject><subject>Dentistry</subject><subject>Drug delivery</subject><subject>Drug delivery systems</subject><subject>Dwell time</subject><subject>Hyperpigmentation</subject><subject>Inflammation</subject><subject>Lasers</subject><subject>Lesions</subject><subject>Medicine</subject><subject>Medicine & Public Health</subject><subject>Occlusion</subject><subject>Optical Devices</subject><subject>Optics</subject><subject>Pain</subject><subject>Patients</subject><subject>Photonics</subject><subject>Pigmentation</subject><subject>Quantum Optics</subject><subject>Review Article</subject><subject>Steroid 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Esmail, Reham Shehab</au><au>Hegazy, Rehab Aly</au><au>Aref, Dina Hesham Fouad</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Comparative study of fractional CO2 laser and fractional CO2 laser-assisted drug delivery of topical steroid and topical vitamin C in macular amyloidosis</atitle><jtitle>Lasers in medical science</jtitle><stitle>Lasers Med Sci</stitle><date>2018-05-01</date><risdate>2018</risdate><volume>33</volume><issue>4</issue><spage>909</spage><epage>916</epage><pages>909-916</pages><issn>0268-8921</issn><eissn>1435-604X</eissn><abstract>Macular amyloidosis (MA) represents a common variant of primary localized cutaneous amyloidosis. It has a characteristic female predominance; none of the treatment modalities described is either curative or uniformly effective in patients with macular amyloidosis. To determine the effect of fractional CO
2
laser in macular amyloidosis in comparison to fractional CO
2
laser-assisted drug delivery of topical steroids and topical vitamin C, the study includes 10 female patients with cutaneous macular amyloidosis aged between 20 and 62 years. Patients were treated with four sessions of fractional CO
2
laser with 4 weeks interval. Laser treatments were performed using fractional CO
2
laser with the following parameters (power 18 W, spacing 800 μm, dwell time 600 μs, stacking 3). The lesion is divided into three areas: area 1, treated by fractional laser only; area 2, treated by fractional laser followed by topical corticosteroid application under occlusion for 24 h; and area 3, treated by fractional laser followed by topical vitamin C serum application under occlusion for 24 h. All lesions were examined clinically and histologically before the therapy and 1 month after the end of the therapy to evaluate the degree of improvement. All treated areas show significant decrease in pigmentation score after treatment, significant drop in rippling (
P
value < 0.016), and improvement of lichenification; as regards the histological improvement, there was a significant decrease of the amyloid amount after treatment. As regards the amyloid amount, results show significant decrease in the amount of amyloid in all of the three treated areas. Area 2 reported the highest decrease in the amyloid amount followed by areas 1 and 3. One patient (10%) was highly satisfied by the treatment, 6 (60%) reported moderate degree of satisfaction, while only 3 (30%) reported mild satisfaction. Minimal complication occurred in the form of post-inflammatory hyperpigmentation in 1 patient. None of the patients suffered pain, ulceration, or infection. Fractional CO
2
alone can be used to improve the texture of macular amyloidosis. If used to assist the delivery of topical steroids and topical vitamin C, improvement can be highly increased.</abstract><cop>London</cop><pub>Springer London</pub><doi>10.1007/s10103-018-2457-1</doi><tpages>8</tpages></addata></record> |
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| ispartof | Lasers in medical science, 2018-05, Vol.33 (4), p.909-916 |
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| language | eng |
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| source | SpringerLink Journals - AutoHoldings |
| subjects | Amyloidosis Ascorbic acid Carbon dioxide Carbon dioxide lasers Clinical outcomes Comparative studies Corticosteroids Dentistry Drug delivery Drug delivery systems Dwell time Hyperpigmentation Inflammation Lasers Lesions Medicine Medicine & Public Health Occlusion Optical Devices Optics Pain Patients Photonics Pigmentation Quantum Optics Review Article Steroid hormones Steroids Therapy Vitamin C |
| title | Comparative study of fractional CO2 laser and fractional CO2 laser-assisted drug delivery of topical steroid and topical vitamin C in macular amyloidosis |
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