Mass Spectrometry-Based Proteomics Reveals Potential Roles of NEK9 and MAP2K4 in Resistance to PI3K Inhibition in Triple-Negative Breast Cancers

Activation of PI3K signaling is frequently observed in triple-negative breast cancer (TNBC), yet PI3K inhibitors have shown limited clinical activity. To investigate intrinsic and adaptive mechanisms of resistance, we analyzed a panel of patient-derived xenograft models of TNBC with varying responsi...

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Veröffentlicht in:	Cancer research (Chicago, Ill.) Ill.), 2018-05, Vol.78 (10), p.2732-2746
Hauptverfasser:	Mundt, Filip, Rajput, Sandeep, Li, Shunqiang, Ruggles, Kelly V, Mooradian, Arshag D, Mertins, Philipp, Gillette, Michael A, Krug, Karsten, Guo, Zhanfang, Hoog, Jeremy, Erdmann-Gilmore, Petra, Primeau, Tina, Huang, Shixia, Edwards, Dean P, Wang, Xiaowei, Wang, Xuya, Kawaler, Emily, Mani, D R, Clauser, Karl R, Gao, Feng, Luo, Jingqin, Davies, Sherri R, Johnson, Gary L, Huang, Kuan-Lin, Yoon, Christopher J, Ding, Li, Fenyö, David, Ellis, Matthew J, Townsend, R Reid, Held, Jason M, Carr, Steven A, Ma, Cynthia X
Format:	Artikel
Sprache:	eng
Schlagworte:	1-Phosphatidylinositol 3-kinase Aminopyridines - pharmacology Animals Antineoplastic Agents - pharmacology Breast cancer Cell Line, Tumor Class I Phosphatidylinositol 3-Kinases - antagonists & inhibitors Class I Phosphatidylinositol 3-Kinases - genetics Female Humans Inhibition Lethality MAP kinase MAP Kinase Kinase 4 - genetics Mass Spectrometry Mass spectroscopy Mice Morpholines - pharmacology NIMA-Related Kinases - genetics Proteomics Proteomics - methods RNA Interference RNA, Small Interfering - genetics Signal Transduction - genetics Triple Negative Breast Neoplasms - drug therapy Triple Negative Breast Neoplasms - pathology Tumors Xenograft Model Antitumor Assays Xenografts
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