Oncogene-induced regulation of microRNA expression: Implications for cancer initiation, progression and therapy

A plethora of tumours have characteristic oncogenic mutations which are the main causes of malignant transformation, exerting their effects through multiple signalling pathways. Downstream of such pathways, microRNAs are small non-coding RNAs that negatively regulate gene expression, assisting or an...

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Veröffentlicht in:	Cancer letters 2018-05, Vol.421, p.152-160
Hauptverfasser:	Paliouras, Athanasios R., Monteverde, Tiziana, Garofalo, Michela
Format:	Artikel
Sprache:	eng
Schlagworte:	Addictions Cancer Cooperation Disease Progression Drug development Gene expression Genetic transformation Humans Kinases Lesions Leukemia Lymphoma Metastases MicroRNA MicroRNA regulation MicroRNAs MicroRNAs - genetics miRNA MiRNA therapeutics Mutation Neoplasms - genetics Neoplasms - pathology Neoplasms - therapy Oncogene addiction Oncogenes Prostate Signal transduction Tumorigenesis Tumors Tumour initiation Tumour progression
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