TRIM37 inhibits PDGF-BB-induced proliferation and migration of airway smooth muscle cells
Tripartite motif 37 (TRIM37) belongs to the TRIM family of proteins and has been reported to be involved in the progression of asthma. However, the effects of TRIM37 on airway smooth muscle cells (ASMCs) proliferation and migration are still unknown. This study aimed to investigate the effects of TR...
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Veröffentlicht in: | Biomedicine & pharmacotherapy 2018-05, Vol.101, p.24-29 |
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description | Tripartite motif 37 (TRIM37) belongs to the TRIM family of proteins and has been reported to be involved in the progression of asthma. However, the effects of TRIM37 on airway smooth muscle cells (ASMCs) proliferation and migration are still unknown. This study aimed to investigate the effects of TRIM37 on cell proliferation and migration in platelet-derived growth factor BB (PDGF-BB)-stimulated ASMCs, and the potential molecular mechanisms was also explored. Our data demonstrated that the expression of TRIM37 was significantly decreased in ASMCs stimulated with PDGF-BB. In addition, overexpression of TRIM37 efficiently suppressed PDGF-BB-induced ASMCs proliferation and migration. Furthermore, overexpression of TRIM37 obviously inhibited the protein expression levels of β-catenin, c-Myc and cyclinD1 in PDGF-BB-stimulated ASMCs. The Wnt/β-catenin pathway activator LiCl significantly reversed the inhibitory effects of TRIM37 on cell proliferation and migration in PDGF-BB-stimulated ASMCs. Taken together, these results demonstrate that TRIM37 inhibits the proliferation and invasion of ASMCs cultured with PDGF-BB through suppressing the Wnt/β-catenin signaling pathway. |
doi_str_mv | 10.1016/j.biopha.2018.02.057 |
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However, the effects of TRIM37 on airway smooth muscle cells (ASMCs) proliferation and migration are still unknown. This study aimed to investigate the effects of TRIM37 on cell proliferation and migration in platelet-derived growth factor BB (PDGF-BB)-stimulated ASMCs, and the potential molecular mechanisms was also explored. Our data demonstrated that the expression of TRIM37 was significantly decreased in ASMCs stimulated with PDGF-BB. In addition, overexpression of TRIM37 efficiently suppressed PDGF-BB-induced ASMCs proliferation and migration. Furthermore, overexpression of TRIM37 obviously inhibited the protein expression levels of β-catenin, c-Myc and cyclinD1 in PDGF-BB-stimulated ASMCs. The Wnt/β-catenin pathway activator LiCl significantly reversed the inhibitory effects of TRIM37 on cell proliferation and migration in PDGF-BB-stimulated ASMCs. Taken together, these results demonstrate that TRIM37 inhibits the proliferation and invasion of ASMCs cultured with PDGF-BB through suppressing the Wnt/β-catenin signaling pathway.</description><identifier>ISSN: 0753-3322</identifier><identifier>EISSN: 1950-6007</identifier><identifier>DOI: 10.1016/j.biopha.2018.02.057</identifier><identifier>PMID: 29477054</identifier><language>eng</language><publisher>France: Elsevier Masson SAS</publisher><subject>Airway smooth muscle cells (ASMCs) ; Angiogenesis Inducing Agents - pharmacology ; Asthma ; Becaplermin ; Cell Line ; Cell Movement - drug effects ; Cell Movement - physiology ; Cell Proliferation - drug effects ; Cell Proliferation - physiology ; Cells, Cultured ; Humans ; Lung - cytology ; Lung - drug effects ; Lung - metabolism ; Migration ; Myocytes, Smooth Muscle - drug effects ; Myocytes, Smooth Muscle - metabolism ; Nuclear Proteins - biosynthesis ; Proliferation ; Proto-Oncogene Proteins c-sis - pharmacology ; TRIM37</subject><ispartof>Biomedicine & pharmacotherapy, 2018-05, Vol.101, p.24-29</ispartof><rights>2018 Elsevier Masson SAS</rights><rights>Copyright © 2018 Elsevier Masson SAS. All rights reserved.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c362t-552392d7cdedaf148d3405be12fc23c25c99ed1f0ef944aefa65f0fe200a8a5a3</citedby><cites>FETCH-LOGICAL-c362t-552392d7cdedaf148d3405be12fc23c25c99ed1f0ef944aefa65f0fe200a8a5a3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://dx.doi.org/10.1016/j.biopha.2018.02.057$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>314,780,784,3548,27923,27924,45994</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/29477054$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Dai, Ying</creatorcontrib><creatorcontrib>Li, Ying</creatorcontrib><creatorcontrib>Cheng, Ruiduo</creatorcontrib><creatorcontrib>Gao, Jie</creatorcontrib><creatorcontrib>Li, Yanyang</creatorcontrib><creatorcontrib>Lou, Chunyan</creatorcontrib><title>TRIM37 inhibits PDGF-BB-induced proliferation and migration of airway smooth muscle cells</title><title>Biomedicine & pharmacotherapy</title><addtitle>Biomed Pharmacother</addtitle><description>Tripartite motif 37 (TRIM37) belongs to the TRIM family of proteins and has been reported to be involved in the progression of asthma. However, the effects of TRIM37 on airway smooth muscle cells (ASMCs) proliferation and migration are still unknown. This study aimed to investigate the effects of TRIM37 on cell proliferation and migration in platelet-derived growth factor BB (PDGF-BB)-stimulated ASMCs, and the potential molecular mechanisms was also explored. Our data demonstrated that the expression of TRIM37 was significantly decreased in ASMCs stimulated with PDGF-BB. In addition, overexpression of TRIM37 efficiently suppressed PDGF-BB-induced ASMCs proliferation and migration. Furthermore, overexpression of TRIM37 obviously inhibited the protein expression levels of β-catenin, c-Myc and cyclinD1 in PDGF-BB-stimulated ASMCs. The Wnt/β-catenin pathway activator LiCl significantly reversed the inhibitory effects of TRIM37 on cell proliferation and migration in PDGF-BB-stimulated ASMCs. Taken together, these results demonstrate that TRIM37 inhibits the proliferation and invasion of ASMCs cultured with PDGF-BB through suppressing the Wnt/β-catenin signaling pathway.</description><subject>Airway smooth muscle cells (ASMCs)</subject><subject>Angiogenesis Inducing Agents - pharmacology</subject><subject>Asthma</subject><subject>Becaplermin</subject><subject>Cell Line</subject><subject>Cell Movement - drug effects</subject><subject>Cell Movement - physiology</subject><subject>Cell Proliferation - drug effects</subject><subject>Cell Proliferation - physiology</subject><subject>Cells, Cultured</subject><subject>Humans</subject><subject>Lung - cytology</subject><subject>Lung - drug effects</subject><subject>Lung - metabolism</subject><subject>Migration</subject><subject>Myocytes, Smooth Muscle - drug effects</subject><subject>Myocytes, Smooth Muscle - metabolism</subject><subject>Nuclear Proteins - biosynthesis</subject><subject>Proliferation</subject><subject>Proto-Oncogene Proteins c-sis - pharmacology</subject><subject>TRIM37</subject><issn>0753-3322</issn><issn>1950-6007</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2018</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp9kE1P3DAQhq2qqGxp_wFCPvaSMLbjOLkgAS0fEgiE6KEny2uPWa-SeLGTIv59s9ptjz2NRnre-XgIOWZQMmD16bpchrhZmZIDa0rgJUj1gSxYK6GoAdRHsgAlRSEE54fkc85rAJC1aD6RQ95WSoGsFuTX89PtvVA0DKuwDGOmj9-vr4qLiyIMbrLo6CbFLnhMZgxxoGZwtA8v-y56akJ6M-809zGOK9pP2XZILXZd_kIOvOkyft3XI_Lz6sfz5U1x93B9e3l-V1hR87GQkouWO2UdOuNZ1ThRgVwi495yYbm0bYuOeUDfVpVBb2rpwSMHMI2RRhyRb7u586WvE-ZR9yFvLzADxinrGVStahhvZrTaoTbFnBN6vUmhN-ldM9BbqXqtd1L1VqoGrmepc-xkv2Fa9uj-hf5anIGzHYDzn78DJp1twGHWFxLaUbsY_r_hD8fNikA</recordid><startdate>201805</startdate><enddate>201805</enddate><creator>Dai, Ying</creator><creator>Li, Ying</creator><creator>Cheng, Ruiduo</creator><creator>Gao, Jie</creator><creator>Li, Yanyang</creator><creator>Lou, Chunyan</creator><general>Elsevier Masson SAS</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>201805</creationdate><title>TRIM37 inhibits PDGF-BB-induced proliferation and migration of airway smooth muscle cells</title><author>Dai, Ying ; Li, Ying ; Cheng, Ruiduo ; Gao, Jie ; Li, Yanyang ; Lou, Chunyan</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c362t-552392d7cdedaf148d3405be12fc23c25c99ed1f0ef944aefa65f0fe200a8a5a3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2018</creationdate><topic>Airway smooth muscle cells (ASMCs)</topic><topic>Angiogenesis Inducing Agents - pharmacology</topic><topic>Asthma</topic><topic>Becaplermin</topic><topic>Cell Line</topic><topic>Cell Movement - drug effects</topic><topic>Cell Movement - physiology</topic><topic>Cell Proliferation - drug effects</topic><topic>Cell Proliferation - physiology</topic><topic>Cells, Cultured</topic><topic>Humans</topic><topic>Lung - cytology</topic><topic>Lung - drug effects</topic><topic>Lung - metabolism</topic><topic>Migration</topic><topic>Myocytes, Smooth Muscle - drug effects</topic><topic>Myocytes, Smooth Muscle - metabolism</topic><topic>Nuclear Proteins - biosynthesis</topic><topic>Proliferation</topic><topic>Proto-Oncogene Proteins c-sis - pharmacology</topic><topic>TRIM37</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Dai, Ying</creatorcontrib><creatorcontrib>Li, Ying</creatorcontrib><creatorcontrib>Cheng, Ruiduo</creatorcontrib><creatorcontrib>Gao, Jie</creatorcontrib><creatorcontrib>Li, Yanyang</creatorcontrib><creatorcontrib>Lou, Chunyan</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Biomedicine & pharmacotherapy</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Dai, Ying</au><au>Li, Ying</au><au>Cheng, Ruiduo</au><au>Gao, Jie</au><au>Li, Yanyang</au><au>Lou, Chunyan</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>TRIM37 inhibits PDGF-BB-induced proliferation and migration of airway smooth muscle cells</atitle><jtitle>Biomedicine & pharmacotherapy</jtitle><addtitle>Biomed Pharmacother</addtitle><date>2018-05</date><risdate>2018</risdate><volume>101</volume><spage>24</spage><epage>29</epage><pages>24-29</pages><issn>0753-3322</issn><eissn>1950-6007</eissn><abstract>Tripartite motif 37 (TRIM37) belongs to the TRIM family of proteins and has been reported to be involved in the progression of asthma. However, the effects of TRIM37 on airway smooth muscle cells (ASMCs) proliferation and migration are still unknown. This study aimed to investigate the effects of TRIM37 on cell proliferation and migration in platelet-derived growth factor BB (PDGF-BB)-stimulated ASMCs, and the potential molecular mechanisms was also explored. Our data demonstrated that the expression of TRIM37 was significantly decreased in ASMCs stimulated with PDGF-BB. In addition, overexpression of TRIM37 efficiently suppressed PDGF-BB-induced ASMCs proliferation and migration. Furthermore, overexpression of TRIM37 obviously inhibited the protein expression levels of β-catenin, c-Myc and cyclinD1 in PDGF-BB-stimulated ASMCs. The Wnt/β-catenin pathway activator LiCl significantly reversed the inhibitory effects of TRIM37 on cell proliferation and migration in PDGF-BB-stimulated ASMCs. Taken together, these results demonstrate that TRIM37 inhibits the proliferation and invasion of ASMCs cultured with PDGF-BB through suppressing the Wnt/β-catenin signaling pathway.</abstract><cop>France</cop><pub>Elsevier Masson SAS</pub><pmid>29477054</pmid><doi>10.1016/j.biopha.2018.02.057</doi><tpages>6</tpages></addata></record> |
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subjects | Airway smooth muscle cells (ASMCs) Angiogenesis Inducing Agents - pharmacology Asthma Becaplermin Cell Line Cell Movement - drug effects Cell Movement - physiology Cell Proliferation - drug effects Cell Proliferation - physiology Cells, Cultured Humans Lung - cytology Lung - drug effects Lung - metabolism Migration Myocytes, Smooth Muscle - drug effects Myocytes, Smooth Muscle - metabolism Nuclear Proteins - biosynthesis Proliferation Proto-Oncogene Proteins c-sis - pharmacology TRIM37 |
title | TRIM37 inhibits PDGF-BB-induced proliferation and migration of airway smooth muscle cells |
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