Discovery of novel P sub(3) sulfonamide-capped inhibitors of HCV NS3 protease. Inhibitors with improved cellular potencies

Hepatitis C Virus (HCV) infection is the major cause of chronic liver disease, leading to cirrhosis and hepatocellular carcinoma, which affects more than 200 million people worldwide. Currently the only therapeutic regimens are subcutaneous interferon- alpha or PEG-interferon alone or in combination...

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Veröffentlicht in:	Bioorganic & medicinal chemistry 2009-07, Vol.17 (13), p.4486-4495
Hauptverfasser:	Venkatraman, Srikanth, Blackman, Mellissa, Wu, Wanli, Nair, Latha, Arasappan, Ashok, Padilla, Angela, Bogen, Stephane, Bennett, Frank, Chen, Kevin, Pichardo, John, Tong, Xiao, Prongay, Andrew, Cheng, Kuo-Chi, Girijavallabhan, Viyyoor, Njoroge, FGeorge
Format:	Artikel
Sprache:	eng
Schlagworte:	Hepatitis C virus
Online-Zugang:	Volltext
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