Stereoselective synthesis of the cytotoxic macrolide aspergillide B
A stereoselective synthesis of the cytotoxic macrolide aspergillide B has been performed. The three key fragments A, B and C were connected with the aid of a cross metathesis (CRM), a Mukaiyama-type C-glycosidation and a macrolactonization. A total, stereoselective synthesis of the cytotoxic macroli...
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Veröffentlicht in: | Tetrahedron letters 2009-07, Vol.50 (27), p.3783-3785 |
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Hauptverfasser: | , , , , , |
Format: | Artikel |
Sprache: | eng |
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Zusammenfassung: | A stereoselective synthesis of the cytotoxic macrolide aspergillide B has been performed. The three key fragments
A,
B and
C were connected with the aid of a cross metathesis (CRM), a Mukaiyama-type C-glycosidation and a macrolactonization.
A total, stereoselective synthesis of the cytotoxic macrolide aspergillide B has been performed. A cross metathesis and a C-glycosidation via a Mukaiyama-type aldol reaction were key features of the synthesis. The macrocyclic lactone ring was created by means of the Yamaguchi procedure. |
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ISSN: | 0040-4039 1873-3581 |
DOI: | 10.1016/j.tetlet.2009.04.026 |