Dermatologic manifestations of acromegaly: A case in point and a focused review

Dermatologic manifestations of acromegaly: A case in point and a focused review

Acromegaly is a systemic syndrome caused by overproduction of growth hormone. Cutaneous, endocrine, cardiovascular, skeletal, and respiratory systems are affected. Cutaneous changes in acromegaly relate to overexpression of growth hormone and insulin-like growth factor 1 on skin cells and adnexa. De...

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Veröffentlicht in:Dermatology online journal 2017-08, Vol.23 (8)
Hauptverfasser: Degirmentepe, Ece Nur, Gungor, Sule, Kocaturk, Emek, Kiziltac, Utkan, Adas, Mine, Ozekinci, Selver, Khachemoune, Amor
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container_issue 8
container_start_page
container_title Dermatology online journal
container_volume 23
creator Degirmentepe, Ece Nur
Gungor, Sule
Kocaturk, Emek
Kiziltac, Utkan
Adas, Mine
Ozekinci, Selver
Khachemoune, Amor
description Acromegaly is a systemic syndrome caused by overproduction of growth hormone. Cutaneous, endocrine, cardiovascular, skeletal, and respiratory systems are affected. Cutaneous changes in acromegaly relate to overexpression of growth hormone and insulin-like growth factor 1 on skin cells and adnexa. Dermal glycosaminoglycan accumulation and edema cause skin distention that is most prominent in the face, hands, and feet. Oily skin with large pores, hypertrichosis, and excessive sweating are common features. Pigmented skin tags, acanthosis nigricans, and psoriasis are also encountered. Cutaneous manifestations of acromegaly are various and prominent, and are an important clue for the early diagnosis and treatment of this high-morbidity disorder.
doi_str_mv 10.5070/D3238036001
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title Dermatologic manifestations of acromegaly: A case in point and a focused review
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