Developmental Analysis of Bone Marrow Neutrophils Reveals Populations Specialized in Expansion, Trafficking, and Effector Functions

Neutrophils are specialized innate cells that require constant replenishment from proliferative bone marrow (BM) precursors as a result of their short half-life. Although it is established that neutrophils are derived from the granulocyte-macrophage progenitor (GMP), the differentiation pathways fro...

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Veröffentlicht in:	Immunity (Cambridge, Mass.) Mass.), 2018-02, Vol.48 (2), p.364-379.e8
Hauptverfasser:	Evrard, Maximilien, Kwok, Immanuel W.H., Chong, Shu Zhen, Teng, Karen W.W., Becht, Etienne, Chen, Jinmiao, Sieow, Je Lin, Penny, Hweixian Leong, Ching, Goh Chi, Devi, Sapna, Adrover, José Maria, Li, Jackson L.Y., Liong, Ka Hang, Tan, Leonard, Poon, Zhiyong, Foo, Shihui, Chua, Jia Wang, Su, I-Hsin, Balabanian, Karl, Bachelerie, Françoise, Biswas, Subhra K., Larbi, Anis, Hwang, William Y.K., Madan, Vikas, Koeffler, H. Phillip, Wong, Siew Cheng, Newell, Evan W., Hidalgo, Andrés, Ginhoux, Florent, Ng, Lai Guan
Format:	Artikel
Sprache:	eng
Schlagworte:	Blood Bone marrow CCAAT/enhancer-binding protein Cell cycle Cytometry Functional analysis Granulocytes Granulopoiesis Homeostasis Leukocytes (granulocytic) Leukocytes (neutrophilic) Macrophages Microorganisms neutrophil development neutrophil ontogeny neutrophil precursors Neutrophils Osteoprogenitor cells Populations Replenishment Sepsis Stem cells trafficking
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