Somatic IL4R mutations in primary mediastinal large B-cell lymphoma lead to constitutive JAK-STAT signaling activation

Primary mediastinal large B-cell lymphoma (PMBCL) is a distinct subtype of diffuse large B-cell lymphoma thought to arise from thymic medullary B cells. Gene mutations underlying the molecular pathogenesis of the disease are incompletely characterized. Here, we describe novel somatic IL4R mutations...

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Veröffentlicht in:	Blood 2018-05, Vol.131 (18), p.2036-2046
Hauptverfasser:	Viganò, Elena, Gunawardana, Jay, Mottok, Anja, Van Tol, Tessa, Mak, Katina, Chan, Fong Chun, Chong, Lauren, Chavez, Elizabeth, Woolcock, Bruce, Takata, Katsuyoshi, Twa, David, Shulha, Hennady P., Telenius, Adèle, Kutovaya, Olga, Hung, Stacy S., Healy, Shannon, Ben-Neriah, Susana, Leroy, Karen, Gaulard, Philippe, Diepstra, Arjan, Kridel, Robert, Savage, Kerry J., Rimsza, Lisa, Gascoyne, Randy, Steidl, Christian
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Cell Line, Tumor Disease Models, Animal Female Humans Interleukin-4 Receptor alpha Subunit - genetics Interleukin-4 Receptor alpha Subunit - metabolism Janus Kinases - metabolism Lymphoma, Large B-Cell, Diffuse - genetics Lymphoma, Large B-Cell, Diffuse - metabolism Mediastinal Neoplasms - genetics Mediastinal Neoplasms - metabolism Mice Mutation Phosphorylation Signal Transduction STAT Transcription Factors - metabolism
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