Stimulatory effect of Cinnamomum cassia and cinnamic acid on angiogenesis through up-regulation of VEGF and Flk-1/KDR expression

Complementary and alternative medicine, Cinnamomum cassia is one of the medicinal plants that have been used to improve various diseases caused by insufficient blood circulation. However, relatively little work has been carried out on the angiogenic responses of C. cassia and its active compound cin...

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Veröffentlicht in:	International immunopharmacology 2009-07, Vol.9 (7), p.959-967
Hauptverfasser:	Choi, Do-Young, Baek, Yong-Hyeon, Huh, Jeong-Eun, Ko, Jeong-Min, Woo, HyunSu, Lee, Jae-Dong, Park, Dong-Suk
Format:	Artikel
Sprache:	eng
Schlagworte:	Angiogenesis Animals Aorta - pathology Biological and medical sciences Cassia Cattle Cell Differentiation - drug effects Cell Movement - drug effects Cell Proliferation - drug effects Cells, Cultured Cinnamates - administration & dosage Cinnamates - pharmacology Cinnamic acid Cinnamomum Cinnamomum aromaticum Cinnamomum cassia Dose-Response Relationship, Drug Endothelial Cells - drug effects Endothelial Cells - immunology Endothelial Cells - metabolism Endothelial Cells - pathology Female Flk-1/KDR General pharmacology Humans Male Medical sciences Mice Mice, Inbred C57BL Neovascularization, Physiologic - drug effects Pharmacognosy. Homeopathy. Health food Pharmacology. Drug treatments Plant Extracts Pregnancy Umbilical Veins - pathology Up-Regulation Vascular Endothelial Growth Factor A - genetics Vascular Endothelial Growth Factor A - immunology Vascular Endothelial Growth Factor A - metabolism Vascular Endothelial Growth Factor Receptor-2 - genetics Vascular Endothelial Growth Factor Receptor-2 - immunology Vascular Endothelial Growth Factor Receptor-2 - metabolism VEGF von Willebrand Factor - genetics von Willebrand Factor - immunology von Willebrand Factor - metabolism
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