Molecular Profiling of Pooled Circulating Tumor Cells from Prostate Cancer Patients Using a Dual-Antibody-Functionalized Microfluidic Device

To capture both epithelial and mesenchymal subpopulations of CTCs at different metastatic stages of PCa patients, here we constructed a novel dual-antibody-functionalized microfluidic device by employing antibodies against PSMA and EpCAM. In vitro experiments with the dual capture system for capturi...

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Veröffentlicht in:	Analytical chemistry (Washington) 2018-03, Vol.90 (6), p.3744-3751
Hauptverfasser:	Yin, Changqing, Wang, Yuhui, Ji, Jia, Cai, Bo, Chen, Hao, Yang, Zhonghua, Wang, Kun, Luo, Changliang, Zhang, Wuwen, Yuan, Chunhui, Wang, Fubing
Format:	Artikel
Sprache:	eng
Schlagworte:	Aged Aged, 80 and over Analytical chemistry Antibodies Antibodies, Immobilized - chemistry Antigens, Surface - analysis Cell Count - instrumentation Cell Separation - instrumentation Chemistry Correlation analysis Deprivation Diagnostic systems Epithelial Cell Adhesion Molecule - analysis Glutamate Carboxypeptidase II - analysis Humans Immunoglobulins Immunotherapy Lab-On-A-Chip Devices Male Microfluidics Middle Aged Neoplastic Cells, Circulating - pathology Patients PD-L1 protein Prostate cancer Prostatic Neoplasms - blood Prostatic Neoplasms - pathology Ribonucleic acid RNA Therapy Tumor necrosis factor-TNF
Online-Zugang:	Volltext
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