Antifungal activity of fluconazole-loaded natural rubber latex against Candida albicans
This work aimed to produce a membrane based on fluconazole-loaded natural rubber latex (NRL), and study their interaction, drug release and antifungal susceptibility against Candida albicans. Fluconazole-loaded NRL membrane was obtained by casting method. The Fourier Transform Infrared Spectroscopy...
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| Veröffentlicht in: | Future microbiology 2018-03, Vol.13 (3), p.359-367 |
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| creator | Yonashiro Marcelino, Mônica Azevedo Borges, Felipe Martins Costa, Ana Flávia de Lacorte Singulani, Junya Ribeiro, Nathan Vinícius Barcelos Costa-Orlandi, Caroline Garms, Bruna Cambraia Soares Mendes-Giannini, Maria José Herculano, Rondinelli Donizetti Fusco-Almeida, Ana Marisa |
| description | This work aimed to produce a membrane based on fluconazole-loaded natural rubber latex (NRL), and study their interaction, drug release and antifungal susceptibility against Candida albicans.
Fluconazole-loaded NRL membrane was obtained by casting method.
The Fourier Transform Infrared Spectroscopy showed no modifications either in NRL or fluconazole after the incorporation. Mechanical test presented low Young's modulus and high strain, indicating the membranes have sufficient elasticity for biomedical application. The bio-membrane was able to release the drug and inhibit the growth of C. albicans as demonstrated by disk diffusion and macrodilution assays.
The biomembrane was able to release fluconazole and inhibit the growth of C. albicans, representing a promising biomaterial for skin application. |
| doi_str_mv | 10.2217/fmb-2017-0154 |
| format | Article |
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Fluconazole-loaded NRL membrane was obtained by casting method.
The Fourier Transform Infrared Spectroscopy showed no modifications either in NRL or fluconazole after the incorporation. Mechanical test presented low Young's modulus and high strain, indicating the membranes have sufficient elasticity for biomedical application. The bio-membrane was able to release the drug and inhibit the growth of C. albicans as demonstrated by disk diffusion and macrodilution assays.
The biomembrane was able to release fluconazole and inhibit the growth of C. albicans, representing a promising biomaterial for skin application.</description><identifier>ISSN: 1746-0913</identifier><identifier>EISSN: 1746-0921</identifier><identifier>DOI: 10.2217/fmb-2017-0154</identifier><identifier>PMID: 29464962</identifier><language>eng</language><publisher>England: Future Medicine Ltd</publisher><subject>Antifungal activity ; Antifungal agents ; Antifungal Agents - chemistry ; Antifungal Agents - pharmacology ; Biomaterials ; Candida albicans ; Candida albicans - drug effects ; Cell adhesion & migration ; Coated Materials, Biocompatible - chemistry ; Coated Materials, Biocompatible - pharmacology ; Drug Liberation ; Fluconazole ; Fluconazole - chemistry ; Fluconazole - pharmacology ; Fourier transforms ; Infrared spectroscopy ; Latex ; Latex - chemistry ; Mechanical properties ; Membranes ; Microbial Sensitivity Tests ; Rubber ; Tensile Strength</subject><ispartof>Future microbiology, 2018-03, Vol.13 (3), p.359-367</ispartof><rights>Copyright Future Medicine Ltd Mar 2018</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c321t-eeb689abd39e20df3591f5975e86a0b7d85445b52b0d62d5285b0bbb896533913</citedby><cites>FETCH-LOGICAL-c321t-eeb689abd39e20df3591f5975e86a0b7d85445b52b0d62d5285b0bbb896533913</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,776,780,27901,27902</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/29464962$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Yonashiro Marcelino, Mônica</creatorcontrib><creatorcontrib>Azevedo Borges, Felipe</creatorcontrib><creatorcontrib>Martins Costa, Ana Flávia</creatorcontrib><creatorcontrib>de Lacorte Singulani, Junya</creatorcontrib><creatorcontrib>Ribeiro, Nathan Vinícius</creatorcontrib><creatorcontrib>Barcelos Costa-Orlandi, Caroline</creatorcontrib><creatorcontrib>Garms, Bruna Cambraia</creatorcontrib><creatorcontrib>Soares Mendes-Giannini, Maria José</creatorcontrib><creatorcontrib>Herculano, Rondinelli Donizetti</creatorcontrib><creatorcontrib>Fusco-Almeida, Ana Marisa</creatorcontrib><title>Antifungal activity of fluconazole-loaded natural rubber latex against Candida albicans</title><title>Future microbiology</title><addtitle>Future Microbiol</addtitle><description>This work aimed to produce a membrane based on fluconazole-loaded natural rubber latex (NRL), and study their interaction, drug release and antifungal susceptibility against Candida albicans.
Fluconazole-loaded NRL membrane was obtained by casting method.
The Fourier Transform Infrared Spectroscopy showed no modifications either in NRL or fluconazole after the incorporation. Mechanical test presented low Young's modulus and high strain, indicating the membranes have sufficient elasticity for biomedical application. The bio-membrane was able to release the drug and inhibit the growth of C. albicans as demonstrated by disk diffusion and macrodilution assays.
The biomembrane was able to release fluconazole and inhibit the growth of C. albicans, representing a promising biomaterial for skin application.</description><subject>Antifungal activity</subject><subject>Antifungal agents</subject><subject>Antifungal Agents - chemistry</subject><subject>Antifungal Agents - pharmacology</subject><subject>Biomaterials</subject><subject>Candida albicans</subject><subject>Candida albicans - drug effects</subject><subject>Cell adhesion & migration</subject><subject>Coated Materials, Biocompatible - chemistry</subject><subject>Coated Materials, Biocompatible - pharmacology</subject><subject>Drug Liberation</subject><subject>Fluconazole</subject><subject>Fluconazole - chemistry</subject><subject>Fluconazole - pharmacology</subject><subject>Fourier transforms</subject><subject>Infrared spectroscopy</subject><subject>Latex</subject><subject>Latex - chemistry</subject><subject>Mechanical properties</subject><subject>Membranes</subject><subject>Microbial Sensitivity Tests</subject><subject>Rubber</subject><subject>Tensile Strength</subject><issn>1746-0913</issn><issn>1746-0921</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2018</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><sourceid>BENPR</sourceid><recordid>eNpd0M9LwzAUwPEgipvTo1cpePFSzY-mTY5j-AsGXhSP4aVJR0eazqQR519vx3QHT3mHD4-XL0KXBN9SSqq7ptM5xaTKMeHFEZqSqihzLCk5PsyETdBZjGuMuSCSnKIJlUVZyJJO0fvcD22T_ApcBvXQfrbDNuubrHGp7j18987mrgdjTeZhSGFkIWltQ-ZgsF8ZrKD1ccgW4E1rIAOn2xp8PEcnDbhoL37fGXp7uH9dPOXLl8fnxXyZ14ySIbdWl0KCNkxaik3DuCQNlxW3ogSsKyN4UXDNqcampIZTwTXWWgtZcsbGn83QzX7vJvQfycZBdW2srXPgbZ-iohhXhDAmqpFe_6PrPgU_Xqcoo0Iwxgs6qnyv6tDHGGyjNqHtIGwVwWpXXI3F1a642hUf_dXv1qQ7aw76LzH7AXPQe40</recordid><startdate>201803</startdate><enddate>201803</enddate><creator>Yonashiro Marcelino, Mônica</creator><creator>Azevedo Borges, Felipe</creator><creator>Martins Costa, Ana Flávia</creator><creator>de Lacorte Singulani, Junya</creator><creator>Ribeiro, Nathan Vinícius</creator><creator>Barcelos Costa-Orlandi, Caroline</creator><creator>Garms, Bruna Cambraia</creator><creator>Soares Mendes-Giannini, Maria José</creator><creator>Herculano, Rondinelli Donizetti</creator><creator>Fusco-Almeida, Ana Marisa</creator><general>Future Medicine Ltd</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7RV</scope><scope>7X7</scope><scope>7XB</scope><scope>88E</scope><scope>8AO</scope><scope>8C1</scope><scope>8FE</scope><scope>8FH</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>AZQEC</scope><scope>BBNVY</scope><scope>BENPR</scope><scope>BHPHI</scope><scope>CCPQU</scope><scope>DWQXO</scope><scope>EHMNL</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>GNUQQ</scope><scope>HCIFZ</scope><scope>K9.</scope><scope>KB0</scope><scope>LK8</scope><scope>M0S</scope><scope>M1P</scope><scope>M7P</scope><scope>NAPCQ</scope><scope>PHGZM</scope><scope>PHGZT</scope><scope>PJZUB</scope><scope>PKEHL</scope><scope>PPXIY</scope><scope>PQEST</scope><scope>PQGLB</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PRINS</scope><scope>7X8</scope></search><sort><creationdate>201803</creationdate><title>Antifungal activity of fluconazole-loaded natural rubber latex against Candida albicans</title><author>Yonashiro Marcelino, Mônica ; Azevedo Borges, Felipe ; Martins Costa, Ana Flávia ; de Lacorte Singulani, Junya ; Ribeiro, Nathan Vinícius ; Barcelos Costa-Orlandi, Caroline ; Garms, Bruna Cambraia ; Soares Mendes-Giannini, Maria José ; Herculano, Rondinelli Donizetti ; Fusco-Almeida, Ana Marisa</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c321t-eeb689abd39e20df3591f5975e86a0b7d85445b52b0d62d5285b0bbb896533913</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2018</creationdate><topic>Antifungal activity</topic><topic>Antifungal agents</topic><topic>Antifungal Agents - chemistry</topic><topic>Antifungal Agents - pharmacology</topic><topic>Biomaterials</topic><topic>Candida albicans</topic><topic>Candida albicans - drug effects</topic><topic>Cell adhesion & migration</topic><topic>Coated Materials, Biocompatible - chemistry</topic><topic>Coated Materials, Biocompatible - pharmacology</topic><topic>Drug Liberation</topic><topic>Fluconazole</topic><topic>Fluconazole - chemistry</topic><topic>Fluconazole - pharmacology</topic><topic>Fourier transforms</topic><topic>Infrared spectroscopy</topic><topic>Latex</topic><topic>Latex - chemistry</topic><topic>Mechanical properties</topic><topic>Membranes</topic><topic>Microbial Sensitivity Tests</topic><topic>Rubber</topic><topic>Tensile Strength</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Yonashiro Marcelino, Mônica</creatorcontrib><creatorcontrib>Azevedo Borges, Felipe</creatorcontrib><creatorcontrib>Martins Costa, Ana Flávia</creatorcontrib><creatorcontrib>de Lacorte Singulani, Junya</creatorcontrib><creatorcontrib>Ribeiro, Nathan Vinícius</creatorcontrib><creatorcontrib>Barcelos Costa-Orlandi, Caroline</creatorcontrib><creatorcontrib>Garms, Bruna Cambraia</creatorcontrib><creatorcontrib>Soares Mendes-Giannini, Maria José</creatorcontrib><creatorcontrib>Herculano, Rondinelli Donizetti</creatorcontrib><creatorcontrib>Fusco-Almeida, Ana Marisa</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Central (Corporate)</collection><collection>Nursing & Allied Health Database</collection><collection>Health & Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Medical Database (Alumni Edition)</collection><collection>ProQuest Pharma Collection</collection><collection>Public Health Database</collection><collection>ProQuest SciTech Collection</collection><collection>ProQuest Natural Science Collection</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>ProQuest Central (Alumni Edition)</collection><collection>ProQuest Central UK/Ireland</collection><collection>ProQuest Central Essentials</collection><collection>Biological Science Collection</collection><collection>ProQuest Central</collection><collection>Natural Science Collection</collection><collection>ProQuest One Community College</collection><collection>ProQuest Central Korea</collection><collection>UK & Ireland Database</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>ProQuest Central Student</collection><collection>SciTech Premium Collection</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Nursing & Allied Health Database (Alumni Edition)</collection><collection>ProQuest Biological Science Collection</collection><collection>Health & Medical Collection (Alumni Edition)</collection><collection>Medical Database</collection><collection>Biological Science Database</collection><collection>Nursing & Allied Health Premium</collection><collection>ProQuest Central (New)</collection><collection>ProQuest One Academic (New)</collection><collection>ProQuest Health & Medical Research Collection</collection><collection>ProQuest One Academic Middle East (New)</collection><collection>ProQuest One Health & Nursing</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Applied & Life Sciences</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>ProQuest Central China</collection><collection>MEDLINE - Academic</collection><jtitle>Future microbiology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Yonashiro Marcelino, Mônica</au><au>Azevedo Borges, Felipe</au><au>Martins Costa, Ana Flávia</au><au>de Lacorte Singulani, Junya</au><au>Ribeiro, Nathan Vinícius</au><au>Barcelos Costa-Orlandi, Caroline</au><au>Garms, Bruna Cambraia</au><au>Soares Mendes-Giannini, Maria José</au><au>Herculano, Rondinelli Donizetti</au><au>Fusco-Almeida, Ana Marisa</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Antifungal activity of fluconazole-loaded natural rubber latex against Candida albicans</atitle><jtitle>Future microbiology</jtitle><addtitle>Future Microbiol</addtitle><date>2018-03</date><risdate>2018</risdate><volume>13</volume><issue>3</issue><spage>359</spage><epage>367</epage><pages>359-367</pages><issn>1746-0913</issn><eissn>1746-0921</eissn><abstract>This work aimed to produce a membrane based on fluconazole-loaded natural rubber latex (NRL), and study their interaction, drug release and antifungal susceptibility against Candida albicans.
Fluconazole-loaded NRL membrane was obtained by casting method.
The Fourier Transform Infrared Spectroscopy showed no modifications either in NRL or fluconazole after the incorporation. Mechanical test presented low Young's modulus and high strain, indicating the membranes have sufficient elasticity for biomedical application. The bio-membrane was able to release the drug and inhibit the growth of C. albicans as demonstrated by disk diffusion and macrodilution assays.
The biomembrane was able to release fluconazole and inhibit the growth of C. albicans, representing a promising biomaterial for skin application.</abstract><cop>England</cop><pub>Future Medicine Ltd</pub><pmid>29464962</pmid><doi>10.2217/fmb-2017-0154</doi><tpages>9</tpages></addata></record> |
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| ispartof | Future microbiology, 2018-03, Vol.13 (3), p.359-367 |
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| source | MEDLINE; PubMed Central |
| subjects | Antifungal activity Antifungal agents Antifungal Agents - chemistry Antifungal Agents - pharmacology Biomaterials Candida albicans Candida albicans - drug effects Cell adhesion & migration Coated Materials, Biocompatible - chemistry Coated Materials, Biocompatible - pharmacology Drug Liberation Fluconazole Fluconazole - chemistry Fluconazole - pharmacology Fourier transforms Infrared spectroscopy Latex Latex - chemistry Mechanical properties Membranes Microbial Sensitivity Tests Rubber Tensile Strength |
| title | Antifungal activity of fluconazole-loaded natural rubber latex against Candida albicans |
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