Urinary liver‐type fatty acid‐binding protein in pediatric nephrotic syndrome and tubular dysfunction
Background Urinary liver‐type fatty acid‐binding protein (uL‐FABP) has recently been identified as a biomarker for kidney injury. uL‐FABP excretion in pediatric relapsing nephrotic syndrome and tubular dysfunction, however, has not been reported previously. Methods We measured uL‐FABP level in child...
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| Veröffentlicht in: | Pediatrics international 2018-05, Vol.60 (5), p.442-445 |
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| creator | Nishida, Masashi Kawakatsu, Hidekazu Hamaoka, Kenji |
| description | Background
Urinary liver‐type fatty acid‐binding protein (uL‐FABP) has recently been identified as a biomarker for kidney injury. uL‐FABP excretion in pediatric relapsing nephrotic syndrome and tubular dysfunction, however, has not been reported previously.
Methods
We measured uL‐FABP level in children with steroid‐sensitive nephrotic syndrome (SSNS), in those with tubular dysfunction, and in control subjects.
Results
uL‐FABP was markedly increased in relapsing SSNS (median, 30.3 μg/gCr; range, 12.6–171.0 μg/gCr; n = 13), and also in the tubular dysfunction group (median, 164.8 μg/gCr; range, 41.6–834.5 μg/gCr; n = 7), compared with the control subjects (median, 3.0 μg/gCr; range, 1.1–13.9 μg/gCr; n = 21). uL‐FABP level was significantly correlated with urinary protein excretion in the SSNS group, and in the total group. Additionally, in the SSNS group, elevated uL‐FABP in the relapsing stage returned to a level similar to that in the control group on remission of NS. In the tubular dysfunction group, uL‐FABP was significantly correlated with urinary β2‐microglobulin.
Conclusion
Urinary protein amount, and the ability of the proximal tubules to reabsorb low‐molecular‐weight proteins, should also be considered when evaluating the clinical significance of uL‐FABP as a biomarker for kidney injury in children. |
| doi_str_mv | 10.1111/ped.13533 |
| format | Article |
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Urinary liver‐type fatty acid‐binding protein (uL‐FABP) has recently been identified as a biomarker for kidney injury. uL‐FABP excretion in pediatric relapsing nephrotic syndrome and tubular dysfunction, however, has not been reported previously.
Methods
We measured uL‐FABP level in children with steroid‐sensitive nephrotic syndrome (SSNS), in those with tubular dysfunction, and in control subjects.
Results
uL‐FABP was markedly increased in relapsing SSNS (median, 30.3 μg/gCr; range, 12.6–171.0 μg/gCr; n = 13), and also in the tubular dysfunction group (median, 164.8 μg/gCr; range, 41.6–834.5 μg/gCr; n = 7), compared with the control subjects (median, 3.0 μg/gCr; range, 1.1–13.9 μg/gCr; n = 21). uL‐FABP level was significantly correlated with urinary protein excretion in the SSNS group, and in the total group. Additionally, in the SSNS group, elevated uL‐FABP in the relapsing stage returned to a level similar to that in the control group on remission of NS. In the tubular dysfunction group, uL‐FABP was significantly correlated with urinary β2‐microglobulin.
Conclusion
Urinary protein amount, and the ability of the proximal tubules to reabsorb low‐molecular‐weight proteins, should also be considered when evaluating the clinical significance of uL‐FABP as a biomarker for kidney injury in children.</description><identifier>ISSN: 1328-8067</identifier><identifier>EISSN: 1442-200X</identifier><identifier>DOI: 10.1111/ped.13533</identifier><identifier>PMID: 29460503</identifier><language>eng</language><publisher>Australia: Blackwell Publishing Ltd</publisher><subject>biomarker ; Biomarkers ; Children ; Excretion ; Fatty acid-binding protein ; Fatty acids ; Kidney diseases ; kidney injury ; Kidneys ; Liver ; Liver diseases ; low‐molecular‐weight protein ; Measurement methods ; Molecular chains ; Nephrotic syndrome ; Pediatrics ; Proteins ; proteinuria ; proximal tubular function ; Proximal tubules ; Remission</subject><ispartof>Pediatrics international, 2018-05, Vol.60 (5), p.442-445</ispartof><rights>2018 Japan Pediatric Society</rights><rights>2018 Japan Pediatric Society.</rights><rights>Copyright © 2018 Japan Pediatric Society</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c3773-b09abfa6ddf8b9439d91f2ae8d52c3b84cd40b4230e7cce6f76b6ada66a4bc843</citedby><cites>FETCH-LOGICAL-c3773-b09abfa6ddf8b9439d91f2ae8d52c3b84cd40b4230e7cce6f76b6ada66a4bc843</cites><orcidid>0000-0003-1768-6996</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://onlinelibrary.wiley.com/doi/pdf/10.1111%2Fped.13533$$EPDF$$P50$$Gwiley$$H</linktopdf><linktohtml>$$Uhttps://onlinelibrary.wiley.com/doi/full/10.1111%2Fped.13533$$EHTML$$P50$$Gwiley$$H</linktohtml><link.rule.ids>314,778,782,1414,27911,27912,45561,45562</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/29460503$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Nishida, Masashi</creatorcontrib><creatorcontrib>Kawakatsu, Hidekazu</creatorcontrib><creatorcontrib>Hamaoka, Kenji</creatorcontrib><title>Urinary liver‐type fatty acid‐binding protein in pediatric nephrotic syndrome and tubular dysfunction</title><title>Pediatrics international</title><addtitle>Pediatr Int</addtitle><description>Background
Urinary liver‐type fatty acid‐binding protein (uL‐FABP) has recently been identified as a biomarker for kidney injury. uL‐FABP excretion in pediatric relapsing nephrotic syndrome and tubular dysfunction, however, has not been reported previously.
Methods
We measured uL‐FABP level in children with steroid‐sensitive nephrotic syndrome (SSNS), in those with tubular dysfunction, and in control subjects.
Results
uL‐FABP was markedly increased in relapsing SSNS (median, 30.3 μg/gCr; range, 12.6–171.0 μg/gCr; n = 13), and also in the tubular dysfunction group (median, 164.8 μg/gCr; range, 41.6–834.5 μg/gCr; n = 7), compared with the control subjects (median, 3.0 μg/gCr; range, 1.1–13.9 μg/gCr; n = 21). uL‐FABP level was significantly correlated with urinary protein excretion in the SSNS group, and in the total group. Additionally, in the SSNS group, elevated uL‐FABP in the relapsing stage returned to a level similar to that in the control group on remission of NS. In the tubular dysfunction group, uL‐FABP was significantly correlated with urinary β2‐microglobulin.
Conclusion
Urinary protein amount, and the ability of the proximal tubules to reabsorb low‐molecular‐weight proteins, should also be considered when evaluating the clinical significance of uL‐FABP as a biomarker for kidney injury in children.</description><subject>biomarker</subject><subject>Biomarkers</subject><subject>Children</subject><subject>Excretion</subject><subject>Fatty acid-binding protein</subject><subject>Fatty acids</subject><subject>Kidney diseases</subject><subject>kidney injury</subject><subject>Kidneys</subject><subject>Liver</subject><subject>Liver diseases</subject><subject>low‐molecular‐weight protein</subject><subject>Measurement methods</subject><subject>Molecular chains</subject><subject>Nephrotic syndrome</subject><subject>Pediatrics</subject><subject>Proteins</subject><subject>proteinuria</subject><subject>proximal tubular function</subject><subject>Proximal tubules</subject><subject>Remission</subject><issn>1328-8067</issn><issn>1442-200X</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2018</creationdate><recordtype>article</recordtype><recordid>eNp1kMtKxDAUhoMo3he-gATc6KIzSZNp0qWMVxB0oeCu5FaNdNKatEp3PoLP6JN4dHQjGAI5_Hz8OXwI7VEyoXCmnbMTymaMraBNynme5YTcr8LMcplJUogNtJXSEyFECsnX0UZe8oLMCNtE_i76oOKIG__i4sfbez92Dteq70esjLeQaB-sDw-4i23vfMBw4UOv-ugNDq57hBymNAYb24XDKljcD3poVMR2TPUQTO_bsIPWatUkt_vzbqO7s9Pb-UV2dX1-OT--ygwTgmWalErXqrC2lrrkrLQlrXPlpJ3lhmnJjeVE85wRJ4xxRS0KXSirikJxbSRn2-hw2Qv7Pg8u9dXCJ-OaRgXXDqkCN4LSnJQU0IM_6FM7xADbAcUFn3FBJFBHS8rENqXo6qqLfgHOKkqqL_8V6Ki-_QO7_9M46AWkv-SvcACmS-DVN278v6m6OT1ZVn4Cdb-TNQ</recordid><startdate>201805</startdate><enddate>201805</enddate><creator>Nishida, Masashi</creator><creator>Kawakatsu, Hidekazu</creator><creator>Hamaoka, Kenji</creator><general>Blackwell Publishing Ltd</general><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7TK</scope><scope>7U9</scope><scope>H94</scope><scope>K9.</scope><scope>7X8</scope><orcidid>https://orcid.org/0000-0003-1768-6996</orcidid></search><sort><creationdate>201805</creationdate><title>Urinary liver‐type fatty acid‐binding protein in pediatric nephrotic syndrome and tubular dysfunction</title><author>Nishida, Masashi ; Kawakatsu, Hidekazu ; Hamaoka, Kenji</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c3773-b09abfa6ddf8b9439d91f2ae8d52c3b84cd40b4230e7cce6f76b6ada66a4bc843</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2018</creationdate><topic>biomarker</topic><topic>Biomarkers</topic><topic>Children</topic><topic>Excretion</topic><topic>Fatty acid-binding protein</topic><topic>Fatty acids</topic><topic>Kidney diseases</topic><topic>kidney injury</topic><topic>Kidneys</topic><topic>Liver</topic><topic>Liver diseases</topic><topic>low‐molecular‐weight protein</topic><topic>Measurement methods</topic><topic>Molecular chains</topic><topic>Nephrotic syndrome</topic><topic>Pediatrics</topic><topic>Proteins</topic><topic>proteinuria</topic><topic>proximal tubular function</topic><topic>Proximal tubules</topic><topic>Remission</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Nishida, Masashi</creatorcontrib><creatorcontrib>Kawakatsu, Hidekazu</creatorcontrib><creatorcontrib>Hamaoka, Kenji</creatorcontrib><collection>PubMed</collection><collection>CrossRef</collection><collection>Neurosciences Abstracts</collection><collection>Virology and AIDS Abstracts</collection><collection>AIDS and Cancer Research Abstracts</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>MEDLINE - Academic</collection><jtitle>Pediatrics international</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Nishida, Masashi</au><au>Kawakatsu, Hidekazu</au><au>Hamaoka, Kenji</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Urinary liver‐type fatty acid‐binding protein in pediatric nephrotic syndrome and tubular dysfunction</atitle><jtitle>Pediatrics international</jtitle><addtitle>Pediatr Int</addtitle><date>2018-05</date><risdate>2018</risdate><volume>60</volume><issue>5</issue><spage>442</spage><epage>445</epage><pages>442-445</pages><issn>1328-8067</issn><eissn>1442-200X</eissn><abstract>Background
Urinary liver‐type fatty acid‐binding protein (uL‐FABP) has recently been identified as a biomarker for kidney injury. uL‐FABP excretion in pediatric relapsing nephrotic syndrome and tubular dysfunction, however, has not been reported previously.
Methods
We measured uL‐FABP level in children with steroid‐sensitive nephrotic syndrome (SSNS), in those with tubular dysfunction, and in control subjects.
Results
uL‐FABP was markedly increased in relapsing SSNS (median, 30.3 μg/gCr; range, 12.6–171.0 μg/gCr; n = 13), and also in the tubular dysfunction group (median, 164.8 μg/gCr; range, 41.6–834.5 μg/gCr; n = 7), compared with the control subjects (median, 3.0 μg/gCr; range, 1.1–13.9 μg/gCr; n = 21). uL‐FABP level was significantly correlated with urinary protein excretion in the SSNS group, and in the total group. Additionally, in the SSNS group, elevated uL‐FABP in the relapsing stage returned to a level similar to that in the control group on remission of NS. In the tubular dysfunction group, uL‐FABP was significantly correlated with urinary β2‐microglobulin.
Conclusion
Urinary protein amount, and the ability of the proximal tubules to reabsorb low‐molecular‐weight proteins, should also be considered when evaluating the clinical significance of uL‐FABP as a biomarker for kidney injury in children.</abstract><cop>Australia</cop><pub>Blackwell Publishing Ltd</pub><pmid>29460503</pmid><doi>10.1111/ped.13533</doi><tpages>4</tpages><orcidid>https://orcid.org/0000-0003-1768-6996</orcidid></addata></record> |
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| source | Wiley Online Library Journals Frontfile Complete |
| subjects | biomarker Biomarkers Children Excretion Fatty acid-binding protein Fatty acids Kidney diseases kidney injury Kidneys Liver Liver diseases low‐molecular‐weight protein Measurement methods Molecular chains Nephrotic syndrome Pediatrics Proteins proteinuria proximal tubular function Proximal tubules Remission |
| title | Urinary liver‐type fatty acid‐binding protein in pediatric nephrotic syndrome and tubular dysfunction |
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