In Vivo Labeling of Mitochondrial Complex I (NADH:UbiquinoneOxidoreductase) in Rat Brain Using [3H]Dihydrorotenone

: Defects in mitochondrial energy metabolism have beenimplicated in several neurodegenerative disorders. Defective complex I(NADH:ubiquinone oxidoreductase) activity plays a key role in Leber'shereditary optic neuropathy and, possibly, Parkinson's disease, but there isno way to assess this...

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Veröffentlicht in:	Journal of neurochemistry 2000-12, Vol.75 (6), p.2611-2621
Hauptverfasser:	Talpade, Deepa J., Greene, James G., Higgins, Donald S., Greenamyre, J. Timothy
Format:	Artikel
Sprache:	eng
Schlagworte:	[3H]Dihydrorotenone Animals Autoradiography Binding, Competitive - drug effects Biological and medical sciences Brain - anatomy & histology Brain - drug effects Brain - enzymology Complex I dihydrorotenone Diverse techniques Electron transport chain Electron Transport Complex I Electron Transport Complex II Fundamental and applied biological sciences. Psychology Heart In vivo Kidney Kidney - enzymology Liver Liver - enzymology Male Malonates - pharmacology Microinjections Mitochondria Mitochondria - drug effects Mitochondria - enzymology Molecular and cellular biology Multienzyme Complexes - antagonists & inhibitors Myocardium - enzymology NADH, NADPH Oxidoreductases - analysis NADH, NADPH Oxidoreductases - metabolism NADH-ubiquinone oxidoreductase Neurodegenerative Diseases - enzymology Organ Specificity Oxidoreductases - antagonists & inhibitors Rats Rats, Sprague-Dawley Rotenone - analogs & derivatives Rotenone - pharmacokinetics Sodium Azide - pharmacology Succinate Dehydrogenase - antagonists & inhibitors Tissue Distribution Tritium
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