An Efficient Reproductive Method for Irs2 super(-/-) Mice with C57BL/6JJcl Genetic Background
Efficient reproduction using natural mating and reproduction technology [in vitro fertilization (IVF) and embryo transfer (ET)] was investigated in IRS2 deficient mice with C57BL/6JJcl genetic background (Irs2 super(-/-) mice) as a typical type 2 diabetes model. From the results using various combin...
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| Veröffentlicht in: | Experimental animals 2008-01, Vol.57 (4), p.407-411 |
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| creator | Hashimoto, Haruo Eto, Tomoo Kamisako, Tsutomu Hoya, Naoko Hatakeyama, Teruhiko Arai, Toshiro Yokosuka, Makoto Ohnishi, Yasuyuki Ito, Mamoru Hioki, Kyoji Suzuki, Ryo Ohsugi, Mitsuru Saito, Muneo Ueyama, Yoshito Yamauchi, Toshimasa Kubota, Naoto Tobe, Kazuyuki Kadowaki, Takashi Tamaoki, Norikazu Nomura, Tatsuji Kosaka, Kinori |
| description | Efficient reproduction using natural mating and reproduction technology [in vitro fertilization (IVF) and embryo transfer (ET)] was investigated in IRS2 deficient mice with C57BL/6JJcl genetic background (Irs2 super(-/-) mice) as a typical type 2 diabetes model. From the results using various combinations of Irs2 super(-/-) and Irs2 super(-/+) mice, the combination of female Irs2 super(-/+) x male Irs2 super(-/-) was found to be more efficient than other combinations. In applications of reproduction technology using IVF and ET, the combination of female Irs2 super(-/+) x male Irs2 super(-/-) involves the possibility of Irs2 super(-/-) production by repeats using female Irs2 super(-/+) mice. However, reproductive continuity using this combination is difficult because of dependence on human technique and the cost of ET. Therefore, we concluded that Irs2 super(-/-) mice should be produced by embryo transfer using Irs2 super(-/-) mice from a colony consisting of female Irs2 super(-/+) x male Irs2 super(-/-). |
| doi_str_mv | 10.1538/expanim.57.407 |
| format | Article |
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From the results using various combinations of Irs2 super(-/-) and Irs2 super(-/+) mice, the combination of female Irs2 super(-/+) x male Irs2 super(-/-) was found to be more efficient than other combinations. In applications of reproduction technology using IVF and ET, the combination of female Irs2 super(-/+) x male Irs2 super(-/-) involves the possibility of Irs2 super(-/-) production by repeats using female Irs2 super(-/+) mice. However, reproductive continuity using this combination is difficult because of dependence on human technique and the cost of ET. Therefore, we concluded that Irs2 super(-/-) mice should be produced by embryo transfer using Irs2 super(-/-) mice from a colony consisting of female Irs2 super(-/+) x male Irs2 super(-/-).</abstract><doi>10.1538/expanim.57.407</doi></addata></record> |
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| title | An Efficient Reproductive Method for Irs2 super(-/-) Mice with C57BL/6JJcl Genetic Background |
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