Alphavirus Replicon Particles Are Highly Immunogenic in the Murine Malaria Model by Homologous or Heterologous Immunization

We evaluated the immunogenicity of virus-like replicon particles (VRP) derived from an attenuated strain of the alphavirus Venezuelan equine encephalitis virus, encoding two pre-erythrocytic Plasmodium yoelii antigens, in mice. Three immunizing doses were superior to two, and the subcutaneous route...

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Veröffentlicht in:	The open vaccine journal 2008-10, Vol.1 (1), p.27-37
Hauptverfasser:	Dobano, C., Weiss, W. R., Kamrud, K. I., Chulay, J. D., Smith, J., Carucci, D. J., Doolan, D. L.
Format:	Artikel
Sprache:	eng
Schlagworte:	Alphavirus Plasmodium yoelii Poxvirus Venezuelan equine encephalitis virus
Online-Zugang:	Volltext
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