Identification of a novel polyketide synthase–nonribosomal peptide synthetase (PKS–NRPS) gene required for the biosynthesis of cyclopiazonic acid in Aspergillus oryzae

Cyclopiazonic acid (CPA) is a mycotoxin produced by several strains of Penicillium and Aspergillus species. Aspergillus oryzae strains used in fermented foods do not produce CPA; however, several wild-type A. oryzae strains produce CPA. Here, we identified a novel polyketide synthase–nonribosomal pe...

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Veröffentlicht in:	Fungal genetics and biology 2008-12, Vol.45 (12), p.1608-1615
Hauptverfasser:	Tokuoka, Masafumi, Seshime, Yasuyo, Fujii, Isao, Kitamoto, Katsuhiko, Takahashi, Tadashi, Koyama, Yasuji
Format:	Artikel
Sprache:	eng
Schlagworte:	Aspergillus oryzae Aspergillus oryzae - enzymology Aspergillus oryzae - genetics Cyclopiazonic acid Gene Deletion Genome, Fungal Indoles - metabolism Mutagenesis, Insertional Penicillium Peptide Synthases - genetics Peptide Synthases - metabolism Polyketide Synthases - genetics Polyketide Synthases - metabolism Polyketide synthase–nonribosomal peptide synthetase (PKS–NRPS) Secondary metabolite Telomere
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