broadly neuroprotective derivative of curcumin
The plant polyphenolic curcumin alters the response of nerve cells to some forms of toxic stress. The steroid-like compound, cyclohexyl bisphenol A, has broad neuroprotective properties that are very distinct from those of curcumin. To incorporate both families of biological activities into a single...
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| Veröffentlicht in: | Journal of neurochemistry 2008-05, Vol.105 (4), p.1336-1345 |
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| container_title | Journal of neurochemistry |
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| creator | Liu, Yuanbin Dargusch, Richard Maher, Pamela Schubert, David |
| description | The plant polyphenolic curcumin alters the response of nerve cells to some forms of toxic stress. The steroid-like compound, cyclohexyl bisphenol A, has broad neuroprotective properties that are very distinct from those of curcumin. To incorporate both families of biological activities into a single molecule, a pyrazole derivative of curcumin, called CNB-001, was synthesized. CNB-001 acquires a new activity and is far superior in neuroprotection assays to either parental molecule, but retains some of the properties of both. It is neuroprotective in cell culture assays for trophic factor withdrawal, oxidative stress, excitotoxicity, and glucose starvation, as well as toxicity from both intracellular and extracellular amyloid. While the creation of CNB-001 was based upon an uncommon approach to drug design, it has the potential of a lead drug candidate for treating multiple conditions involving nerve cell death. |
| doi_str_mv | 10.1111/j.1471-4159.2008.05236.x |
| format | Article |
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The steroid-like compound, cyclohexyl bisphenol A, has broad neuroprotective properties that are very distinct from those of curcumin. To incorporate both families of biological activities into a single molecule, a pyrazole derivative of curcumin, called CNB-001, was synthesized. CNB-001 acquires a new activity and is far superior in neuroprotection assays to either parental molecule, but retains some of the properties of both. It is neuroprotective in cell culture assays for trophic factor withdrawal, oxidative stress, excitotoxicity, and glucose starvation, as well as toxicity from both intracellular and extracellular amyloid. While the creation of CNB-001 was based upon an uncommon approach to drug design, it has the potential of a lead drug candidate for treating multiple conditions involving nerve cell death.</description><identifier>ISSN: 0022-3042</identifier><identifier>EISSN: 1471-4159</identifier><identifier>DOI: 10.1111/j.1471-4159.2008.05236.x</identifier><identifier>PMID: 18208543</identifier><identifier>CODEN: JONRA9</identifier><language>eng</language><publisher>Oxford, UK: Oxford, UK : Blackwell Publishing Ltd</publisher><subject>amyloid ; Animals ; Biochemistry ; Biological and medical sciences ; Cell culture ; Cell Survival - drug effects ; Cell Survival - physiology ; Cells, Cultured ; Chemical synthesis ; curcumin ; Curcumin - analogs & derivatives ; Curcumin - chemical synthesis ; Curcumin - pharmacology ; Dose-Response Relationship, Drug ; drug ; drugs ; glutamate ; Medical sciences ; Mice ; Neurology ; Neuropharmacology ; neuroprotection ; Neuroprotective agent ; Neuroprotective Agents - chemical synthesis ; Neuroprotective Agents - pharmacology ; Oxidative Stress - drug effects ; Oxidative Stress - physiology ; oxytosis ; Pesticides, fertilizers and other agrochemicals toxicology ; Pharmacology ; Pharmacology. Drug treatments ; Pyrazoles - chemical synthesis ; Pyrazoles - pharmacology ; Rats ; toxicity ; Toxicology</subject><ispartof>Journal of neurochemistry, 2008-05, Vol.105 (4), p.1336-1345</ispartof><rights>2008 The Authors. Journal Compilation © 2008 International Society for Neurochemistry</rights><rights>2008 INIST-CNRS</rights><rights>Journal compilation © 2008 International Society for Neurochemistry</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c5956-35e378619447c3b322079598129ef371077e8b4f2767e817f4c49e43787bf123</citedby><cites>FETCH-LOGICAL-c5956-35e378619447c3b322079598129ef371077e8b4f2767e817f4c49e43787bf123</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://onlinelibrary.wiley.com/doi/pdf/10.1111%2Fj.1471-4159.2008.05236.x$$EPDF$$P50$$Gwiley$$H</linktopdf><linktohtml>$$Uhttps://onlinelibrary.wiley.com/doi/full/10.1111%2Fj.1471-4159.2008.05236.x$$EHTML$$P50$$Gwiley$$H</linktohtml><link.rule.ids>314,776,780,1411,1427,27903,27904,45553,45554,46388,46812</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=20317183$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/18208543$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Liu, Yuanbin</creatorcontrib><creatorcontrib>Dargusch, Richard</creatorcontrib><creatorcontrib>Maher, Pamela</creatorcontrib><creatorcontrib>Schubert, David</creatorcontrib><title>broadly neuroprotective derivative of curcumin</title><title>Journal of neurochemistry</title><addtitle>J Neurochem</addtitle><description>The plant polyphenolic curcumin alters the response of nerve cells to some forms of toxic stress. The steroid-like compound, cyclohexyl bisphenol A, has broad neuroprotective properties that are very distinct from those of curcumin. To incorporate both families of biological activities into a single molecule, a pyrazole derivative of curcumin, called CNB-001, was synthesized. CNB-001 acquires a new activity and is far superior in neuroprotection assays to either parental molecule, but retains some of the properties of both. It is neuroprotective in cell culture assays for trophic factor withdrawal, oxidative stress, excitotoxicity, and glucose starvation, as well as toxicity from both intracellular and extracellular amyloid. While the creation of CNB-001 was based upon an uncommon approach to drug design, it has the potential of a lead drug candidate for treating multiple conditions involving nerve cell death.</description><subject>amyloid</subject><subject>Animals</subject><subject>Biochemistry</subject><subject>Biological and medical sciences</subject><subject>Cell culture</subject><subject>Cell Survival - drug effects</subject><subject>Cell Survival - physiology</subject><subject>Cells, Cultured</subject><subject>Chemical synthesis</subject><subject>curcumin</subject><subject>Curcumin - analogs & derivatives</subject><subject>Curcumin - chemical synthesis</subject><subject>Curcumin - pharmacology</subject><subject>Dose-Response Relationship, Drug</subject><subject>drug</subject><subject>drugs</subject><subject>glutamate</subject><subject>Medical sciences</subject><subject>Mice</subject><subject>Neurology</subject><subject>Neuropharmacology</subject><subject>neuroprotection</subject><subject>Neuroprotective agent</subject><subject>Neuroprotective Agents - chemical synthesis</subject><subject>Neuroprotective Agents - pharmacology</subject><subject>Oxidative Stress - drug effects</subject><subject>Oxidative Stress - physiology</subject><subject>oxytosis</subject><subject>Pesticides, fertilizers and other agrochemicals toxicology</subject><subject>Pharmacology</subject><subject>Pharmacology. Drug treatments</subject><subject>Pyrazoles - chemical synthesis</subject><subject>Pyrazoles - pharmacology</subject><subject>Rats</subject><subject>toxicity</subject><subject>Toxicology</subject><issn>0022-3042</issn><issn>1471-4159</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2008</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqNkMtOwzAURC0EoqXwC1AhwS7B14_YWbBAFU9VsKCsLce1Uao0Absp7d_jtBVIrPDGI_nM-N5BaAg4hXiuZikwAQkDnqcEY5liTmiWrvZQ_-dhH_UxJiShmJEeOgphhjFkLIND1ANJsOSM9lFa-EZPq_Wwtq1vPnyzsGZRLu1wan251BvZuKFpvWnnZX2MDpyugj3Z3QM0ubudjB6S8cv94-hmnBie8yyh3FIhM8gZE4YWlBAscp5LILl1VAAWwsqCOSKyKEA4ZlhuWfSIwgGhA3S5jY0DfbY2LNS8DMZWla5t0wYVd44LcxHB8z_grGl9HUeLTMY5BsoiJLeQ8U0I3jr14cu59msFWHV9qpnqalNdbV22VJs-1SpaT3f5bTG301_jrsAIXOwAHYyunNe1KcMPRzAFAbLjrrfcV1nZ9b8HUE_Po05F_9nW73Sj9LuPf7y9krhehKXMMKPfe7OWjg</recordid><startdate>200805</startdate><enddate>200805</enddate><creator>Liu, Yuanbin</creator><creator>Dargusch, Richard</creator><creator>Maher, Pamela</creator><creator>Schubert, David</creator><general>Oxford, UK : Blackwell Publishing Ltd</general><general>Blackwell Publishing Ltd</general><general>Blackwell</general><scope>FBQ</scope><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7QR</scope><scope>7TK</scope><scope>7U7</scope><scope>7U9</scope><scope>8FD</scope><scope>C1K</scope><scope>FR3</scope><scope>H94</scope><scope>P64</scope></search><sort><creationdate>200805</creationdate><title>broadly neuroprotective derivative of curcumin</title><author>Liu, Yuanbin ; Dargusch, Richard ; Maher, Pamela ; Schubert, David</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c5956-35e378619447c3b322079598129ef371077e8b4f2767e817f4c49e43787bf123</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2008</creationdate><topic>amyloid</topic><topic>Animals</topic><topic>Biochemistry</topic><topic>Biological and medical sciences</topic><topic>Cell culture</topic><topic>Cell Survival - drug effects</topic><topic>Cell Survival - physiology</topic><topic>Cells, Cultured</topic><topic>Chemical synthesis</topic><topic>curcumin</topic><topic>Curcumin - analogs & derivatives</topic><topic>Curcumin - chemical synthesis</topic><topic>Curcumin - pharmacology</topic><topic>Dose-Response Relationship, Drug</topic><topic>drug</topic><topic>drugs</topic><topic>glutamate</topic><topic>Medical sciences</topic><topic>Mice</topic><topic>Neurology</topic><topic>Neuropharmacology</topic><topic>neuroprotection</topic><topic>Neuroprotective agent</topic><topic>Neuroprotective Agents - chemical synthesis</topic><topic>Neuroprotective Agents - pharmacology</topic><topic>Oxidative Stress - drug effects</topic><topic>Oxidative Stress - physiology</topic><topic>oxytosis</topic><topic>Pesticides, fertilizers and other agrochemicals toxicology</topic><topic>Pharmacology</topic><topic>Pharmacology. Drug treatments</topic><topic>Pyrazoles - chemical synthesis</topic><topic>Pyrazoles - pharmacology</topic><topic>Rats</topic><topic>toxicity</topic><topic>Toxicology</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Liu, Yuanbin</creatorcontrib><creatorcontrib>Dargusch, Richard</creatorcontrib><creatorcontrib>Maher, Pamela</creatorcontrib><creatorcontrib>Schubert, David</creatorcontrib><collection>AGRIS</collection><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Chemoreception Abstracts</collection><collection>Neurosciences Abstracts</collection><collection>Toxicology Abstracts</collection><collection>Virology and AIDS Abstracts</collection><collection>Technology Research Database</collection><collection>Environmental Sciences and Pollution Management</collection><collection>Engineering Research Database</collection><collection>AIDS and Cancer Research Abstracts</collection><collection>Biotechnology and BioEngineering Abstracts</collection><jtitle>Journal of neurochemistry</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Liu, Yuanbin</au><au>Dargusch, Richard</au><au>Maher, Pamela</au><au>Schubert, David</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>broadly neuroprotective derivative of curcumin</atitle><jtitle>Journal of neurochemistry</jtitle><addtitle>J Neurochem</addtitle><date>2008-05</date><risdate>2008</risdate><volume>105</volume><issue>4</issue><spage>1336</spage><epage>1345</epage><pages>1336-1345</pages><issn>0022-3042</issn><eissn>1471-4159</eissn><coden>JONRA9</coden><abstract>The plant polyphenolic curcumin alters the response of nerve cells to some forms of toxic stress. The steroid-like compound, cyclohexyl bisphenol A, has broad neuroprotective properties that are very distinct from those of curcumin. To incorporate both families of biological activities into a single molecule, a pyrazole derivative of curcumin, called CNB-001, was synthesized. CNB-001 acquires a new activity and is far superior in neuroprotection assays to either parental molecule, but retains some of the properties of both. It is neuroprotective in cell culture assays for trophic factor withdrawal, oxidative stress, excitotoxicity, and glucose starvation, as well as toxicity from both intracellular and extracellular amyloid. While the creation of CNB-001 was based upon an uncommon approach to drug design, it has the potential of a lead drug candidate for treating multiple conditions involving nerve cell death.</abstract><cop>Oxford, UK</cop><pub>Oxford, UK : Blackwell Publishing Ltd</pub><pmid>18208543</pmid><doi>10.1111/j.1471-4159.2008.05236.x</doi><tpages>10</tpages><oa>free_for_read</oa></addata></record> |
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| subjects | amyloid Animals Biochemistry Biological and medical sciences Cell culture Cell Survival - drug effects Cell Survival - physiology Cells, Cultured Chemical synthesis curcumin Curcumin - analogs & derivatives Curcumin - chemical synthesis Curcumin - pharmacology Dose-Response Relationship, Drug drug drugs glutamate Medical sciences Mice Neurology Neuropharmacology neuroprotection Neuroprotective agent Neuroprotective Agents - chemical synthesis Neuroprotective Agents - pharmacology Oxidative Stress - drug effects Oxidative Stress - physiology oxytosis Pesticides, fertilizers and other agrochemicals toxicology Pharmacology Pharmacology. Drug treatments Pyrazoles - chemical synthesis Pyrazoles - pharmacology Rats toxicity Toxicology |
| title | broadly neuroprotective derivative of curcumin |
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