Isolation and structural elucidation of callipeltins J–M: antifungal peptides from the marine sponge Latrunculia sp

Isolation and structural elucidation of callipeltins J–M: antifungal peptides from the marine sponge Latrunculia sp

Continued investigation of the polar extracts of the marine sponge Latrunculia sp. has resulted in the discovery of callipeltins J–M. The new structures were determined by interpretation of their NMR and MS data. The stereochemistry of the unusual 3-methylglutamine residue in callipeltins J and K wa...

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Veröffentlicht in:Tetrahedron 2007, Vol.63 (1), p.131-140
Hauptverfasser: D'Auria, Maria Valeria, Sepe, Valentina, D'Orsi, Rosa, Bellotta, Filomena, Debitus, Cécile, Zampella, Angela
Format: Artikel
Sprache:eng
Schlagworte:
Antifungal
Callipeltin
Latrunculia
Marine
Peptides
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Zusammenfassung:Continued investigation of the polar extracts of the marine sponge Latrunculia sp. has resulted in the discovery of callipeltins J–M. The new structures were determined by interpretation of their NMR and MS data. The stereochemistry of the unusual 3-methylglutamine residue in callipeltins J and K was secured by stereoselective synthesis and Marfey's LC–MS analysis. [Display omitted]
ISSN:0040-4020
1464-5416
DOI:10.1016/j.tet.2006.10.032