Phase I-II trial of twice-weekly gemcitabine and concomitant irradiation in patients undergoing pancreaticoduodenectomy with extended lymphadenectomy for locally advanced pancreatic cancer

Define the maximum tolerated dose (MTD), tolerability, and efficacy of gemcitabine given concomitantly with radiotherapy in patients with locally advanced pancreatic cancer. Patients were required to have locally advanced T1–T3 resectable pancreatic cancer. Gemcitabine, given twice weekly before irr...

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Veröffentlicht in:	International journal of radiation oncology, biology, physics biology, physics, 2004-10, Vol.60 (2), p.444-452
Hauptverfasser:	Joensuu, Timo K., Kiviluoto, Tuula, Kärkkäinen, Päivi, Vento, Pälvi, Kivisaari, Leena, Tenhunen, Mikko, Westberg, Ronny, Elomaa, Inkeri
Format:	Artikel
Sprache:	eng
Schlagworte:	Adult Aged Aged, 80 and over Antimetabolites, Antineoplastic - administration & dosage Antimetabolites, Antineoplastic - adverse effects Biological and medical sciences Carcinoma, Pancreatic Ductal - drug therapy Carcinoma, Pancreatic Ductal - pathology Carcinoma, Pancreatic Ductal - radiotherapy Carcinoma, Pancreatic Ductal - surgery Combined Modality Therapy Deoxycytidine - administration & dosage Deoxycytidine - adverse effects Deoxycytidine - analogs & derivatives Female Gemcitabine Humans Lymph Node Excision Male Maximum Tolerated Dose Medical sciences Middle Aged Neoadjuvant chemoradiotherapy Neoadjuvant Therapy Pancreatectomy Pancreatic cancer Pancreatic Neoplasms - drug therapy Pancreatic Neoplasms - pathology Pancreatic Neoplasms - radiotherapy Pancreatic Neoplasms - surgery Pancreaticoduodenectomy Radiation-Sensitizing Agents - administration & dosage Radiation-Sensitizing Agents - adverse effects Radical surgery Radiotherapy Dosage Radiotherapy. Instrumental treatment. Physiotherapy. Reeducation. Rehabilitation, orthophony, crenotherapy. Diet therapy and various other treatments (general aspects) Technology. Biomaterials. Equipments. Material. Instrumentation
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