Natural small molecule bigelovin suppresses orthotopic colorectal tumor growth and inhibits colorectal cancer metastasis via IL6/STAT3 pathway

[Display omitted] Bigelovin, a sesquiterpene lactone, has been demonstrated to induce apoptosis, inhibit inflammation and angiogenesis in vitro, but its potential anti-metastatic activity remains unclear. In the present study, two colon cancer mouse models, orthotopic tumor allografts and experiment...

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Veröffentlicht in:	Biochemical pharmacology 2018-04, Vol.150, p.191-201
Hauptverfasser:	Li, Mingyue, Yue, Grace Gar-Lee, Song, Li-Hua, Huang, Mao-Bo, Lee, Julia Kin-Ming, Tsui, Stephen Kwok-Wing, Fung, Kwok-Pui, Tan, Ning-Hua, Lau, Clara Bik-San
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Bigelovin Cell Movement - drug effects Cell Movement - physiology Colorectal cancer Colorectal Neoplasms - drug therapy Colorectal Neoplasms - metabolism Growth Inhibitors - administration & dosage HCT116 Cells Humans IL6/STAT3 pathway Injections, Intravenous Interleukin-6 - antagonists & inhibitors Interleukin-6 - metabolism Lactones - administration & dosage Male Metastasis Mice Mice, Nude Sesquiterpenes - administration & dosage Signal Transduction - drug effects Signal Transduction - physiology STAT3 Transcription Factor - antagonists & inhibitors STAT3 Transcription Factor - metabolism Tumor microenvironment Xenograft Model Antitumor Assays - methods
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