Engineering a Clinically Translatable Bioartificial Pancreas to Treat Type I Diabetes

Encapsulating, or immunoisolating, insulin-secreting cells within implantable, semipermeable membranes is an emerging treatment for type 1 diabetes. This approach can eliminate the need for immunosuppressive drug treatments to prevent transplant rejection and overcome the shortage of donor tissues b...

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Veröffentlicht in:	Trends in biotechnology (Regular ed.) 2018-04, Vol.36 (4), p.445-456
Hauptverfasser:	Orive, Gorka, Emerich, Dwaine, Khademhosseini, Ali, Matsumoto, Shinichi, Hernández, R.M., Pedraz, J.L., Desai, Tejal, Calafiore, Riccardo, de Vos, Paul
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Bioartificial Organs Biocompatibility Biomedical materials Clinical Trials as Topic Diabetes Diabetes mellitus Diabetes mellitus (insulin dependent) Diabetes Mellitus, Experimental - therapy Diabetes Mellitus, Type 1 - therapy Encapsulation Fourier transforms Graft rejection Humans Immune system Immunoglobulins Immunosuppressive agents Insulin Insulin-Secreting Cells - chemistry Insulin-Secreting Cells - transplantation Mammals Materials Testing Membranes Membranes, Artificial Metabolism Metabolites Models, Animal Pancreas Pancreas, Artificial Physiology Rodents Semipermeable membranes Stem cells Tissue Engineering
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