ESTABLISHMENT OF THREE HUMAN BREAST EPITHELIAL CELL LINES DERIVED FROM CARRIERS OF THE 999del5 BRCA2 ICELANDIC FOUNDER MUTATION

Germ line mutations in BRCA1 and BRCA2 account for a large proportion of inherited breast and ovarian cancer. Both genes are involved in DNA repair by homologous recombination and are thought to play a vital role in maintaining genomic stability. A major drawback for long-term functional studies of...

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Veröffentlicht in:	In vitro cellular & developmental biology. Animal 2005-11, Vol.41 (10), p.337-342
Hauptverfasser:	RUBNER FRIDRIKSDOTTIR, AGLA J, GUDJONSSON, THORARINN, HALLDORSSON, THORHALLUR, BJÖRNSSON, JOHANNES, STEINARSDOTTIR, MARGRET, JOHANNSSON, OSKAR THOR, ÖGMUNDSDOTTIR, HELGA M
Format:	Artikel
Sprache:	eng
Schlagworte:	BRCA2 mutation Breast - cytology Breast cancer CELL AND TISSUE MODELS Cell Line, Tumor Cell lines Chromosomal Instability - genetics Cultured cells Cytogenetic Analysis DNA Mutational Analysis DNA Primers Epithelial cells Epithelial Cells - cytology Exons Female Genes, BRCA2 Genetic mutation Genetic Vectors - genetics Humans Iceland immortalization Immunohistochemistry Karyotyping Keratins - metabolism Mutation - genetics Oncogenes - genetics Retroviridae Stem cells Tumor cell line Tumor stem cells Tumors
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