Negative Association Between Sclerostin and INSL3 in Isolated Human Osteocytes and in Klinefelter Syndrome: New Hints for Testis–Bone Crosstalk

Abstract Context The regulation of bone mass by the testis is a well-recognized mechanism, but the role of Leydig-specific marker insulin-like 3 peptide (INSL3) on the most abundant bone cell population, osteocytes, is unknown. In this study, we aimed to investigate the relationship between INSL3 an...

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Veröffentlicht in:	The journal of clinical endocrinology and metabolism 2018-05, Vol.103 (5), p.2033-2041
Hauptverfasser:	Di Nisio, Andrea, De Toni, Luca, Rocca, Maria Santa, Ghezzi, Marco, Selice, Riccardo, Taglialavoro, Giuseppe, Ferlin, Alberto, Foresta, Carlo
Format:	Artikel
Sprache:	eng
Schlagworte:	Adult Bone density Bone growth Bone mass Bone mineral density Bone Morphogenetic Proteins - blood Bone Morphogenetic Proteins - genetics Bone Morphogenetic Proteins - metabolism Bone turnover Case-Control Studies Cells, Cultured Dual energy X-ray absorptiometry Energy measurement Enzyme-linked immunosorbent assay Female Femur Fluorescence Gene expression Gene Expression - drug effects Genetic Markers - genetics Humans Immunofluorescence Insulin Insulin - blood Insulin - metabolism Insulin - pharmacology Klinefelter Syndrome - blood Klinefelter Syndrome - genetics Klinefelter Syndrome - metabolism Klinefelter Syndrome - pathology Klinefelter's syndrome Male Metabolism Middle Aged Osteocytes Osteocytes - drug effects Osteocytes - metabolism Osteocytes - pathology Osteogenesis Osteoporosis Parathyroid Hormone - pharmacology Polymerase chain reaction Proteins - metabolism Proteins - pharmacology Retrospective Studies Reverse transcription SOST protein Spine Spine (lumbar) Therapeutic applications Young Adult
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