A Sulfonozanamivir Analogue Has Potent Anti‐influenza Virus Activity

Influenza virus infection continues to cause significant, often severe, respiratory illness worldwide. A validated target for the development of anti‐influenza agents is the virus surface protein sialidase. In the current study, we have discovered a highly potent inhibitor of influenza virus sialida...

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Veröffentlicht in:	ChemMedChem 2018-04, Vol.13 (8), p.785-789
Hauptverfasser:	Hadházi, Ádám, Li, Linghui, Bailly, Benjamin, Maggioni, Andrea, Martin, Gael, Dirr, Larissa, Dyason, Jeffrey C., Thomson, Robin J., Gao, George F., Borbás, Anikó, Ve, Thomas, Pascolutti, Mauro, von Itzstein, Mark
Format:	Artikel
Sprache:	eng
Schlagworte:	antiviral agents Antiviral Agents - chemistry Antiviral Agents - pharmacology Arylsulfonates - chemistry Arylsulfonates - pharmacology Catalytic Domain - drug effects Crystallography Crystallography, X-Ray Drug development Humans Influenza Influenza A virus - chemistry Influenza A virus - drug effects Influenza A virus - enzymology Influenza A virus - physiology influenza virus Influenza, Human - drug therapy Influenza, Human - virology Molecular Docking Simulation Neuraminidase - antagonists & inhibitors Neuraminidase - chemistry Neuraminidase - metabolism Respiratory diseases sialic acid sialidase sulfonates Virus Replication - drug effects Viruses Zanamivir Zanamivir - analogs & derivatives Zanamivir - pharmacology
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