A Critical Evaluation of In Vitro Hesperidin 2S Bioavailability in a Model Combining Luminal (Microbial) Digestion and Caco‐2 Cell Absorption in Comparison to a Randomized Controlled Human Trial

Scope Bioavailability strongly determines polyphenol bioactivity, and is strongly influenced by food matrix, enzymatic and microbial degradation, and gastrointestinal absorption. To avoid human trials for pre‐screening of polyphenol bioavailability, studies have focused on in vitro model development...

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Veröffentlicht in:	Molecular nutrition & food research 2018-04, Vol.62 (8), p.e1700881-n/a
Hauptverfasser:	Rymenant, Evelien, Salden, Bouke, Voorspoels, Stefan, Jacobs, Griet, Noten, Bart, Pitart, Judit, Possemiers, Sam, Smagghe, Guy, Grootaert, Charlotte, Camp, John
Format:	Artikel
Sprache:	eng
Schlagworte:	Absorption Acids Antioxidants - administration & dosage Antioxidants - analysis Antioxidants - metabolism Bioavailability Biological activity Caco-2 Cells Caco‐2 Cinnamates - blood Cinnamates - metabolism Cinnamates - urine Citrus sinensis - chemistry Colon Computer simulation Degradation Dietary Supplements Digestion Double-Blind Method Female Flavonoids - administration & dosage Flavonoids - blood Flavonoids - metabolism Flavonoids - urine Food matrix Fruit - chemistry Gastrointestinal Microbiome Glucuronides - blood Glucuronides - metabolism Glucuronides - urine Hesperidin Hesperidin - administration & dosage Hesperidin - blood Hesperidin - metabolism Hesperidin - urine human Humans Hydrolysis Intestinal Absorption Kinetics Male Mathematical models Microbial degradation microbiota Microorganisms Models, Biological Plant Extracts - administration & dosage Plant Extracts - metabolism SHIME Small intestine Stomach Surface Properties Transport Urine
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