CD163-expressing monocytes constitute an endotoxin-sensitive Hb clearance compartment within the vascular system

Hemoglobin (Hb) is released into the circulation during intravascular hemolysis and exerts toxic effects through oxidative damage and NO scavenging. According to the traditional concept of Hb clearance, free Hb is bound to the plasma protein haptoglobin (Hp), and the Hb‐Hp complexes are cleared by l...

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Veröffentlicht in:	Journal of leukocyte biology 2007-07, Vol.82 (1), p.106-110
Hauptverfasser:	Schaer, Christian A., Vallelian, Florence, Imhof, Alexander, Schoedon, Gabriele, Schaer, Dominik J.
Format:	Artikel
Sprache:	eng
Schlagworte:	Antigens, CD - physiology Antigens, Differentiation, Myelomonocytic - physiology Blood Vessels haptoglobin Haptoglobins - metabolism hemoglobin Hemoglobins - metabolism Hemolysis Humans Inflammation - etiology Lipopolysaccharides - pharmacology macrophage Monocytes - physiology Receptors, Cell Surface - physiology
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