A Complex Role for Lipocalin 2 in Bone Metabolism: Global Ablation in Mice Induces Osteopenia Caused by an Altered Energy Metabolism

ABSTRACT Lipocalin 2 (Lcn2) is an adipokine that carries out a variety of functions in diverse organs. We investigated the bone phenotype and the energy metabolism of Lcn2 globally deleted mice (Lcn2–/–) at different ages. Lcn2–/– mice were largely osteopenic, exhibiting lower trabecular bone volume...

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Veröffentlicht in:	Journal of bone and mineral research 2018-06, Vol.33 (6), p.1141-1153
Hauptverfasser:	Capulli, Mattia, Ponzetti, Marco, Maurizi, Antonio, Gemini‐Piperni, Sara, Berger, Thorsten, Mak, Tak Wah, Teti, Anna, Rucci, Nadia
Format:	Artikel
Sprache:	eng
Schlagworte:	Alkaline phosphatase Blood glucose Body weight Bone growth Bone marrow BONE METABOLISM Bone turnover Calvaria Cancellous bone ENERGY METABOLISM Glucose Glucose metabolism Glucose tolerance Glucose transporter GLUT1 Hyperinsulinemia Hyperphagia Insulin LCN2 Lipocalin Metabolism Mineralization NGAL OSTEOBLAST Osteoblasts Osteogenesis Osteopenia Phenotypes Polyuria Protein transport Proteinuria Renal cortex Rodents Stromal cells
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