Predictive performance of a genetic risk score using 11 susceptibility alleles for the incidence of Type 2 diabetes in a general Japanese population: a nested case–control study

Aims To assess the predictive ability of a genetic risk score for the incidence of Type 2 diabetes in a general Japanese population. Methods This prospective case–control study, nested within a Japan Public Health Centre‐based prospective study, included 466 participants with incident Type 2 diabete...

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Veröffentlicht in:	Diabetic medicine 2018-05, Vol.35 (5), p.602-611
Hauptverfasser:	Goto, A., Noda, M., Goto, M., Yasuda, K., Mizoue, T., Yamaji, T., Sawada, N., Iwasaki, M., Inoue, M., Tsugane, S.
Format:	Artikel
Sprache:	eng
Schlagworte:	Adult Aged Alleles Alpha-Ketoglutarate-Dependent Dioxygenase FTO - genetics Asian Continental Ancestry Group - genetics Biochemical markers Case-Control Studies Cyclin-Dependent Kinase Inhibitor p15 - genetics Cyclin-Dependent Kinase Inhibitor p16 Cyclin-Dependent Kinase Inhibitor p18 - genetics Diabetes Diabetes mellitus Diabetes mellitus (non-insulin dependent) Diabetes Mellitus, Type 2 - epidemiology Diabetes Mellitus, Type 2 - genetics Female Genetic Predisposition to Disease Genomes Homeodomain Proteins - genetics Humans Incidence Insulin Receptor Substrate Proteins - genetics Insulin-Like Growth Factor Binding Protein 2 - genetics Japan - epidemiology KCNQ1 Potassium Channel - genetics KCNQ1 protein Male Middle Aged Nuclear Proteins - genetics Potassium channels (voltage-gated) Potassium Channels, Inwardly Rectifying - genetics PPAR gamma - genetics Prospective Studies Public health Reclassification Risk Assessment Risk Factors Single-nucleotide polymorphism Transcription Factor 7-Like 2 Protein - genetics Transcription Factors - genetics tRNA Methyltransferases - genetics Ubiquitin-Conjugating Enzymes - genetics
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