α‑Alkylation of Chiral Sulfinimines for Constructing Quaternary Chiral Carbons by Introducing Removable Directing Groups
This study developed a facile and efficient synthetic strategy to construct quaternary chiral centers at the α-position of imines and ketones. High regioselectivity and diastereoselectivity were achieved through the synergetic effect of electron-withdrawing directing groups and N-tert-butyl sulfinam...
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| Veröffentlicht in: | Organic letters 2018-03, Vol.20 (5), p.1350-1354 |
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| container_end_page | 1354 |
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| container_issue | 5 |
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| container_title | Organic letters |
| container_volume | 20 |
| creator | Qin, Shuanglin Liu, Shuangwei Cao, Yuting Li, Jiangnan Chong, Chuanke Liu, Tongtong Luo, Yunhao Hu, Jiyun Jiang, Shende Zhou, Honggang Yang, Guang Yang, Cheng |
| description | This study developed a facile and efficient synthetic strategy to construct quaternary chiral centers at the α-position of imines and ketones. High regioselectivity and diastereoselectivity were achieved through the synergetic effect of electron-withdrawing directing groups and N-tert-butyl sulfinamide as chiral auxiliaries. Either of them could be removed under the optimized conditions without any epimerization. |
| doi_str_mv | 10.1021/acs.orglett.8b00105 |
| format | Article |
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High regioselectivity and diastereoselectivity were achieved through the synergetic effect of electron-withdrawing directing groups and N-tert-butyl sulfinamide as chiral auxiliaries. 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| identifier | ISSN: 1523-7060 |
| ispartof | Organic letters, 2018-03, Vol.20 (5), p.1350-1354 |
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| language | eng |
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| source | ACS Publications |
| title | α‑Alkylation of Chiral Sulfinimines for Constructing Quaternary Chiral Carbons by Introducing Removable Directing Groups |
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