Diffuse Astrocytoma, IDH-Wildtype: A Dissolving Diagnosis

Abstract The histological and molecular features and even the mere existence of diffuse astrocytoma, IDH-wildtype, remain unclear. We therefore examined 212 diffuse astrocytomas (grade II WHO) in adults using IDH1(R132H) immunohistochemistry followed by IDH1/IDH2 sequencing and neuroimaging review....

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Veröffentlicht in:	Journal of neuropathology and experimental neurology 2018-06, Vol.77 (6), p.422-425
Hauptverfasser:	Hasselblatt, Martin, Jaber, Mohammed, Reuss, David, Grauer, Oliver, Bibo, Annkatrin, Terwey, Stephanie, Schick, Uta, Ebel, Heinrich, Niederstadt, Thomas, Stummer, Walter, von Deimling, Andreas, Paulus, Werner
Format:	Artikel
Sprache:	eng
Schlagworte:	Adolescent Adult Aged Aged, 80 and over Astrocytoma Astrocytoma - classification Astrocytoma - diagnosis Astrocytoma - genetics Brain Neoplasms - classification Brain Neoplasms - diagnosis Brain Neoplasms - genetics Diagnosis Disease Progression DNA Methylation Female Genetic aspects Glioblastoma - classification Glioblastoma - diagnosis Glioblastoma - genetics Health aspects Humans Immunohistochemistry Isocitrate dehydrogenase Isocitrate Dehydrogenase - biosynthesis Isocitrate Dehydrogenase - genetics Male Middle Aged Molecular Diagnostic Techniques Mutation - genetics Young Adult
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