A case report of thyroid metastasis from p16-positive oropharyngeal squamous cell carcinoma
Thyroid metastasis from head and neck squamous cell carcinoma (SCC) is a very rare form of rarely observed metastatic thyroid tumor. We herein report a case of thyroid metastasis from oropharyngeal SCC (OSCC). The patient was a 68-year-old male diagnosed with p16-positive tonsillar OSCC on the right...
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| Veröffentlicht in: | ENDOCRINE JOURNAL 2018, Vol.65(4), pp.479-483 |
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| creator | Takenobu, Masao Moritani, Sueyoshi Yoshioka, Kana Morisaki, Tsuyoshi Kitano, Hiroya |
| description | Thyroid metastasis from head and neck squamous cell carcinoma (SCC) is a very rare form of rarely observed metastatic thyroid tumor. We herein report a case of thyroid metastasis from oropharyngeal SCC (OSCC). The patient was a 68-year-old male diagnosed with p16-positive tonsillar OSCC on the right side with multiple lymph node metastases and a thyroid mass, which was determined as metastatic p16-positive OSCC by immunohistochemistry of specimens collected by fine-needle aspiration cytology (FNAC). He received one cycle of induction chemotherapy followed by concurrent chemoradiotherapy. No visible primary lesions were observed after treatment. The disappearance of the tonsillar lesion was considered to be a complete response by the magnetic resonance imaging (MRI) and positron emission tomography-computed tomography (PET-CT). The thyroid lesion was also decreased, but a solid lesion with unclear boundaries in the right thyroid lobe remained. Therefore, the patient underwent total thyroidectomy to remove any residual tumor. Postoperative pathological evaluation revealed no residual viable carcinoma cells in the resected specimen. As illustrated in this case, immunohistochemistry of the FNAC specimen for p16 was successful in determining the thyroid tumor as a metastatic lesion from the oropharynx. Although radical radiotherapy might be sufficient to control thyroid gland metastasis of OSCC, in this case, early-stage remedial surgery was thought to be necessary for a secure radical cure. |
| doi_str_mv | 10.1507/endocrj.EJ17-0553 |
| format | Article |
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We herein report a case of thyroid metastasis from oropharyngeal SCC (OSCC). The patient was a 68-year-old male diagnosed with p16-positive tonsillar OSCC on the right side with multiple lymph node metastases and a thyroid mass, which was determined as metastatic p16-positive OSCC by immunohistochemistry of specimens collected by fine-needle aspiration cytology (FNAC). He received one cycle of induction chemotherapy followed by concurrent chemoradiotherapy. No visible primary lesions were observed after treatment. The disappearance of the tonsillar lesion was considered to be a complete response by the magnetic resonance imaging (MRI) and positron emission tomography-computed tomography (PET-CT). The thyroid lesion was also decreased, but a solid lesion with unclear boundaries in the right thyroid lobe remained. Therefore, the patient underwent total thyroidectomy to remove any residual tumor. Postoperative pathological evaluation revealed no residual viable carcinoma cells in the resected specimen. As illustrated in this case, immunohistochemistry of the FNAC specimen for p16 was successful in determining the thyroid tumor as a metastatic lesion from the oropharynx. Although radical radiotherapy might be sufficient to control thyroid gland metastasis of OSCC, in this case, early-stage remedial surgery was thought to be necessary for a secure radical cure.</description><identifier>ISSN: 0918-8959</identifier><identifier>EISSN: 1348-4540</identifier><identifier>DOI: 10.1507/endocrj.EJ17-0553</identifier><identifier>PMID: 29445071</identifier><language>eng</language><publisher>Japan: The Japan Endocrine Society</publisher><subject>Aged ; Biopsy ; Carcinoma, Squamous Cell - diagnostic imaging ; Carcinoma, Squamous Cell - secondary ; Carcinoma, Squamous Cell - surgery ; Case reports ; Chemoradiotherapy ; Chemotherapy ; Computed tomography ; Cytology ; Fine needle aspiration cytology ; Head & neck cancer ; Head and neck cancer ; Humans ; Immunohistochemistry ; Lymph nodes ; Magnetic Resonance Imaging ; Male ; Metastases ; Metastasis ; NMR ; Nuclear magnetic resonance ; Oropharyngeal Neoplasms - diagnostic imaging ; Oropharyngeal Neoplasms - pathology ; Oropharyngeal Neoplasms - surgery ; Oropharyngeal squamous cell carcinoma ; Oropharynx ; P16 positive ; Patients ; Positron emission tomography ; Positron Emission Tomography Computed Tomography ; Radiation therapy ; Squamous cell carcinoma ; Surgery ; Thyroid ; Thyroid gland ; Thyroid metastasis ; Thyroid Neoplasms - diagnostic imaging ; Thyroid Neoplasms - secondary ; Thyroid Neoplasms - surgery ; Thyroidectomy ; Tonsil ; Treatment Outcome</subject><ispartof>Endocrine Journal, 2018, Vol.65(4), pp.479-483</ispartof><rights>The Japan Endocrine Society</rights><rights>Copyright Japan Science and Technology Agency 2018</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c691t-61b0c4a1727a4f60b14f50a2a5df3278bec045a4ca3bbab3e6888e7f9ba6a7493</citedby><cites>FETCH-LOGICAL-c691t-61b0c4a1727a4f60b14f50a2a5df3278bec045a4ca3bbab3e6888e7f9ba6a7493</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,780,784,1883,27924,27925</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/29445071$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Takenobu, Masao</creatorcontrib><creatorcontrib>Moritani, Sueyoshi</creatorcontrib><creatorcontrib>Yoshioka, Kana</creatorcontrib><creatorcontrib>Morisaki, Tsuyoshi</creatorcontrib><creatorcontrib>Kitano, Hiroya</creatorcontrib><creatorcontrib>Department of Otolaryngology</creatorcontrib><creatorcontrib>Otolaryngology Head and Neck Thyroid Surgery</creatorcontrib><creatorcontrib>Head and Neck Surgery</creatorcontrib><creatorcontrib>Tottori University Faculty of Medicine</creatorcontrib><creatorcontrib>Kusatsu General Hospital</creatorcontrib><title>A case report of thyroid metastasis from p16-positive oropharyngeal squamous cell carcinoma</title><title>ENDOCRINE JOURNAL</title><addtitle>Endocr J</addtitle><description>Thyroid metastasis from head and neck squamous cell carcinoma (SCC) is a very rare form of rarely observed metastatic thyroid tumor. We herein report a case of thyroid metastasis from oropharyngeal SCC (OSCC). The patient was a 68-year-old male diagnosed with p16-positive tonsillar OSCC on the right side with multiple lymph node metastases and a thyroid mass, which was determined as metastatic p16-positive OSCC by immunohistochemistry of specimens collected by fine-needle aspiration cytology (FNAC). He received one cycle of induction chemotherapy followed by concurrent chemoradiotherapy. No visible primary lesions were observed after treatment. The disappearance of the tonsillar lesion was considered to be a complete response by the magnetic resonance imaging (MRI) and positron emission tomography-computed tomography (PET-CT). The thyroid lesion was also decreased, but a solid lesion with unclear boundaries in the right thyroid lobe remained. Therefore, the patient underwent total thyroidectomy to remove any residual tumor. Postoperative pathological evaluation revealed no residual viable carcinoma cells in the resected specimen. As illustrated in this case, immunohistochemistry of the FNAC specimen for p16 was successful in determining the thyroid tumor as a metastatic lesion from the oropharynx. Although radical radiotherapy might be sufficient to control thyroid gland metastasis of OSCC, in this case, early-stage remedial surgery was thought to be necessary for a secure radical cure.</description><subject>Aged</subject><subject>Biopsy</subject><subject>Carcinoma, Squamous Cell - diagnostic imaging</subject><subject>Carcinoma, Squamous Cell - secondary</subject><subject>Carcinoma, Squamous Cell - surgery</subject><subject>Case reports</subject><subject>Chemoradiotherapy</subject><subject>Chemotherapy</subject><subject>Computed tomography</subject><subject>Cytology</subject><subject>Fine needle aspiration cytology</subject><subject>Head & neck cancer</subject><subject>Head and neck cancer</subject><subject>Humans</subject><subject>Immunohistochemistry</subject><subject>Lymph nodes</subject><subject>Magnetic Resonance Imaging</subject><subject>Male</subject><subject>Metastases</subject><subject>Metastasis</subject><subject>NMR</subject><subject>Nuclear magnetic resonance</subject><subject>Oropharyngeal Neoplasms - diagnostic imaging</subject><subject>Oropharyngeal Neoplasms - pathology</subject><subject>Oropharyngeal Neoplasms - surgery</subject><subject>Oropharyngeal squamous cell carcinoma</subject><subject>Oropharynx</subject><subject>P16 positive</subject><subject>Patients</subject><subject>Positron emission tomography</subject><subject>Positron Emission Tomography Computed Tomography</subject><subject>Radiation therapy</subject><subject>Squamous cell carcinoma</subject><subject>Surgery</subject><subject>Thyroid</subject><subject>Thyroid gland</subject><subject>Thyroid metastasis</subject><subject>Thyroid Neoplasms - diagnostic imaging</subject><subject>Thyroid Neoplasms - secondary</subject><subject>Thyroid Neoplasms - surgery</subject><subject>Thyroidectomy</subject><subject>Tonsil</subject><subject>Treatment Outcome</subject><issn>0918-8959</issn><issn>1348-4540</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2018</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNpdkU9r3DAQxUVpabZpP0AvRdBLLk5H1l8fQ0jTlkAv7akHMdbKiRbb8kreQL595ezWgYIYgfTTm6c3hHxkcMkk6C9-3EaXdpc3P5iuQEr-imwYF6YSUsBrsoGGmco0sjkj73LeAXAuBX9LzupGiCLANuTPFXWYPU1-immmsaPzw1OKYUsHP2MuK2TapTjQialqijnM4dHTmOL0gOlpvPfY07w_4BAPmTrf90UvuTDGAd-TNx322X847efk99ebX9ffqruft9-vr-4qpxo2V4q14AQyXWsUnYKWiU4C1ii3Ha-1ab0DIVE45G2LLffKGON117SoUIuGn5OLo-6U4v7g82yHkBcrOPriytYAtTB1zRf083_oLh7SWNwViouGCS51odiRcinmnHxnpxSG8l3LwC7J21PydkneLsmXN59Oyod28Nv1xb-oC3B7BMptcNjHsQ-jf-nv9upZtRhhxgIoCaJsjQWhl2I4B13O1IvSrszn3q-tMM3B9X41p6QVS1lNroQrsysY_wvI8rFL</recordid><startdate>20180101</startdate><enddate>20180101</enddate><creator>Takenobu, Masao</creator><creator>Moritani, Sueyoshi</creator><creator>Yoshioka, Kana</creator><creator>Morisaki, Tsuyoshi</creator><creator>Kitano, Hiroya</creator><general>The Japan Endocrine Society</general><general>Japan Science and Technology Agency</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7QP</scope><scope>7T5</scope><scope>7TK</scope><scope>8FD</scope><scope>FR3</scope><scope>H94</scope><scope>P64</scope><scope>RC3</scope><scope>7X8</scope></search><sort><creationdate>20180101</creationdate><title>A case report of thyroid metastasis from p16-positive oropharyngeal squamous cell carcinoma</title><author>Takenobu, Masao ; Moritani, Sueyoshi ; Yoshioka, Kana ; Morisaki, Tsuyoshi ; Kitano, Hiroya</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c691t-61b0c4a1727a4f60b14f50a2a5df3278bec045a4ca3bbab3e6888e7f9ba6a7493</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2018</creationdate><topic>Aged</topic><topic>Biopsy</topic><topic>Carcinoma, Squamous Cell - diagnostic imaging</topic><topic>Carcinoma, Squamous Cell - secondary</topic><topic>Carcinoma, Squamous Cell - surgery</topic><topic>Case reports</topic><topic>Chemoradiotherapy</topic><topic>Chemotherapy</topic><topic>Computed tomography</topic><topic>Cytology</topic><topic>Fine needle aspiration cytology</topic><topic>Head & neck cancer</topic><topic>Head and neck cancer</topic><topic>Humans</topic><topic>Immunohistochemistry</topic><topic>Lymph nodes</topic><topic>Magnetic Resonance Imaging</topic><topic>Male</topic><topic>Metastases</topic><topic>Metastasis</topic><topic>NMR</topic><topic>Nuclear magnetic resonance</topic><topic>Oropharyngeal Neoplasms - diagnostic imaging</topic><topic>Oropharyngeal Neoplasms - pathology</topic><topic>Oropharyngeal Neoplasms - surgery</topic><topic>Oropharyngeal squamous cell carcinoma</topic><topic>Oropharynx</topic><topic>P16 positive</topic><topic>Patients</topic><topic>Positron emission tomography</topic><topic>Positron Emission Tomography Computed Tomography</topic><topic>Radiation therapy</topic><topic>Squamous cell carcinoma</topic><topic>Surgery</topic><topic>Thyroid</topic><topic>Thyroid gland</topic><topic>Thyroid metastasis</topic><topic>Thyroid Neoplasms - diagnostic imaging</topic><topic>Thyroid Neoplasms - secondary</topic><topic>Thyroid Neoplasms - surgery</topic><topic>Thyroidectomy</topic><topic>Tonsil</topic><topic>Treatment Outcome</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Takenobu, Masao</creatorcontrib><creatorcontrib>Moritani, Sueyoshi</creatorcontrib><creatorcontrib>Yoshioka, Kana</creatorcontrib><creatorcontrib>Morisaki, Tsuyoshi</creatorcontrib><creatorcontrib>Kitano, Hiroya</creatorcontrib><creatorcontrib>Department of Otolaryngology</creatorcontrib><creatorcontrib>Otolaryngology Head and Neck Thyroid Surgery</creatorcontrib><creatorcontrib>Head and Neck Surgery</creatorcontrib><creatorcontrib>Tottori University Faculty of Medicine</creatorcontrib><creatorcontrib>Kusatsu General Hospital</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Calcium & Calcified Tissue Abstracts</collection><collection>Immunology Abstracts</collection><collection>Neurosciences Abstracts</collection><collection>Technology Research Database</collection><collection>Engineering Research Database</collection><collection>AIDS and Cancer Research Abstracts</collection><collection>Biotechnology and BioEngineering Abstracts</collection><collection>Genetics Abstracts</collection><collection>MEDLINE - Academic</collection><jtitle>ENDOCRINE JOURNAL</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Takenobu, Masao</au><au>Moritani, Sueyoshi</au><au>Yoshioka, Kana</au><au>Morisaki, Tsuyoshi</au><au>Kitano, Hiroya</au><aucorp>Department of Otolaryngology</aucorp><aucorp>Otolaryngology Head and Neck Thyroid Surgery</aucorp><aucorp>Head and Neck Surgery</aucorp><aucorp>Tottori University Faculty of Medicine</aucorp><aucorp>Kusatsu General Hospital</aucorp><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>A case report of thyroid metastasis from p16-positive oropharyngeal squamous cell carcinoma</atitle><jtitle>ENDOCRINE JOURNAL</jtitle><addtitle>Endocr J</addtitle><date>2018-01-01</date><risdate>2018</risdate><volume>65</volume><issue>4</issue><spage>479</spage><epage>483</epage><pages>479-483</pages><issn>0918-8959</issn><eissn>1348-4540</eissn><abstract>Thyroid metastasis from head and neck squamous cell carcinoma (SCC) is a very rare form of rarely observed metastatic thyroid tumor. We herein report a case of thyroid metastasis from oropharyngeal SCC (OSCC). The patient was a 68-year-old male diagnosed with p16-positive tonsillar OSCC on the right side with multiple lymph node metastases and a thyroid mass, which was determined as metastatic p16-positive OSCC by immunohistochemistry of specimens collected by fine-needle aspiration cytology (FNAC). He received one cycle of induction chemotherapy followed by concurrent chemoradiotherapy. No visible primary lesions were observed after treatment. The disappearance of the tonsillar lesion was considered to be a complete response by the magnetic resonance imaging (MRI) and positron emission tomography-computed tomography (PET-CT). The thyroid lesion was also decreased, but a solid lesion with unclear boundaries in the right thyroid lobe remained. Therefore, the patient underwent total thyroidectomy to remove any residual tumor. Postoperative pathological evaluation revealed no residual viable carcinoma cells in the resected specimen. As illustrated in this case, immunohistochemistry of the FNAC specimen for p16 was successful in determining the thyroid tumor as a metastatic lesion from the oropharynx. Although radical radiotherapy might be sufficient to control thyroid gland metastasis of OSCC, in this case, early-stage remedial surgery was thought to be necessary for a secure radical cure.</abstract><cop>Japan</cop><pub>The Japan Endocrine Society</pub><pmid>29445071</pmid><doi>10.1507/endocrj.EJ17-0553</doi><tpages>5</tpages><oa>free_for_read</oa></addata></record> |
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| subjects | Aged Biopsy Carcinoma, Squamous Cell - diagnostic imaging Carcinoma, Squamous Cell - secondary Carcinoma, Squamous Cell - surgery Case reports Chemoradiotherapy Chemotherapy Computed tomography Cytology Fine needle aspiration cytology Head & neck cancer Head and neck cancer Humans Immunohistochemistry Lymph nodes Magnetic Resonance Imaging Male Metastases Metastasis NMR Nuclear magnetic resonance Oropharyngeal Neoplasms - diagnostic imaging Oropharyngeal Neoplasms - pathology Oropharyngeal Neoplasms - surgery Oropharyngeal squamous cell carcinoma Oropharynx P16 positive Patients Positron emission tomography Positron Emission Tomography Computed Tomography Radiation therapy Squamous cell carcinoma Surgery Thyroid Thyroid gland Thyroid metastasis Thyroid Neoplasms - diagnostic imaging Thyroid Neoplasms - secondary Thyroid Neoplasms - surgery Thyroidectomy Tonsil Treatment Outcome |
| title | A case report of thyroid metastasis from p16-positive oropharyngeal squamous cell carcinoma |
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