Gene-environment Interaction: The Causes of High Obesity Incidence
Urbanization has provided experimental settings for testing the interactive relationship between genetic background and changes in lifestyle and dietary patterns. The concept of gene-environment interaction was described by epidemic of obesity along with urbanization. Genome-wide association has ide...
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| Veröffentlicht in: | Kathmandu University medical journal 2017-01, Vol.15 (57), p.91-93 |
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| container_title | Kathmandu University medical journal |
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| creator | Ellulu, Mohammed S Jalambo, Marwan O |
| description | Urbanization has provided experimental settings for testing the interactive relationship between genetic background and changes in lifestyle and dietary patterns. The concept of gene-environment interaction was described by epidemic of obesity along with urbanization. Genome-wide association has identified several genes such as melanocortin-4 receptor that associates with environmental influences of obesity. Gene environment (GxE) interaction refers to modification by an environmental factor of the effect of a genetic variant on a phenotypic trait. GxE interactions can serve to modulate the adverse effects of a risk allele, or can exacerbate the genotype-phenotype relationship and increase risk. |
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The concept of gene-environment interaction was described by epidemic of obesity along with urbanization. Genome-wide association has identified several genes such as melanocortin-4 receptor that associates with environmental influences of obesity. Gene environment (GxE) interaction refers to modification by an environmental factor of the effect of a genetic variant on a phenotypic trait. 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| fulltext | fulltext |
| identifier | EISSN: 1812-2078 |
| ispartof | Kathmandu University medical journal, 2017-01, Vol.15 (57), p.91-93 |
| issn | 1812-2078 |
| language | eng |
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| source | MEDLINE; EZB-FREE-00999 freely available EZB journals |
| subjects | Environment Female Gene-Environment Interaction Genome-Wide Association Study - methods Humans Incidence Male Obesity - epidemiology Obesity - etiology Obesity - genetics Phenotype Receptor, Melanocortin, Type 4 - genetics Urban Renewal |
| title | Gene-environment Interaction: The Causes of High Obesity Incidence |
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