Investigation of cancer-associated fibroblasts and p62 expression in oral cancer before and after chemotherapy
The aim of this study is to investigate the expression of the autophagy protein p62 in oral squamous cell carcinoma (OSCC) cells before and after chemotherapy. We also detected cancer-associated fibroblasts (CAFs) in these OSCC samples to explore the roles of p62 and CAFs in chemotherapy. Immunohist...
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Veröffentlicht in: | Journal of cranio-maxillo-facial surgery 2018-04, Vol.46 (4), p.605-610 |
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container_title | Journal of cranio-maxillo-facial surgery |
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creator | Liang, Lizhong Luo, Haiji He, Qifen You, Yingying Fan, Yunping Liang, Jun |
description | The aim of this study is to investigate the expression of the autophagy protein p62 in oral squamous cell carcinoma (OSCC) cells before and after chemotherapy. We also detected cancer-associated fibroblasts (CAFs) in these OSCC samples to explore the roles of p62 and CAFs in chemotherapy.
Immunohistochemistry was used to analyze the expression of p62 and α-SMA in 26 paired OSCC samples before and after chemotherapy. The relationships between clinicopathological features, clinical outcome and the expression of these proteins were analyzed.
Our results indicated an increased stromal α-SMA expression after chemotherapy in OSCC samples. High p62 expression of OSCC cells closely correlated with stromal α-SMA expression after chemotherapy. Furthermore, the post-chemotherapy p62 expression was associated with the prognosis for OSCC patients.
These results suggest that chemotherapy may increase CAFs in OSCC. High cytoplasmic p62 expression may serve as a poor prognostic marker for OSCC patients.
•CAFs increased after chemotherapy in OSCC samples.•High p62 expression of OSCC cells correlated with stromal α-SMA expression.•The post-chemotherapy p62 expression correlated with the prognosis for OSCC patients. |
doi_str_mv | 10.1016/j.jcms.2017.12.016 |
format | Article |
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Immunohistochemistry was used to analyze the expression of p62 and α-SMA in 26 paired OSCC samples before and after chemotherapy. The relationships between clinicopathological features, clinical outcome and the expression of these proteins were analyzed.
Our results indicated an increased stromal α-SMA expression after chemotherapy in OSCC samples. High p62 expression of OSCC cells closely correlated with stromal α-SMA expression after chemotherapy. Furthermore, the post-chemotherapy p62 expression was associated with the prognosis for OSCC patients.
These results suggest that chemotherapy may increase CAFs in OSCC. High cytoplasmic p62 expression may serve as a poor prognostic marker for OSCC patients.
•CAFs increased after chemotherapy in OSCC samples.•High p62 expression of OSCC cells correlated with stromal α-SMA expression.•The post-chemotherapy p62 expression correlated with the prognosis for OSCC patients.</description><identifier>ISSN: 1010-5182</identifier><identifier>EISSN: 1878-4119</identifier><identifier>DOI: 10.1016/j.jcms.2017.12.016</identifier><identifier>PMID: 29439841</identifier><language>eng</language><publisher>Scotland: Elsevier Ltd</publisher><subject>Cancer-associated fibroblasts ; Chemotherapy ; Dentistry ; Oral squamous cell carcinoma ; p62</subject><ispartof>Journal of cranio-maxillo-facial surgery, 2018-04, Vol.46 (4), p.605-610</ispartof><rights>2017 European Association for Cranio-Maxillo-Facial Surgery</rights><rights>Copyright © 2017 European Association for Cranio-Maxillo-Facial Surgery. Published by Elsevier Ltd. All rights reserved.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c356t-b6244a58f6afe6f6b2e9d26d9bf399f29dabc9582d8e0d9e8dc80f6ba5274c083</citedby><cites>FETCH-LOGICAL-c356t-b6244a58f6afe6f6b2e9d26d9bf399f29dabc9582d8e0d9e8dc80f6ba5274c083</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://dx.doi.org/10.1016/j.jcms.2017.12.016$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>314,780,784,3550,27924,27925,45995</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/29439841$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Liang, Lizhong</creatorcontrib><creatorcontrib>Luo, Haiji</creatorcontrib><creatorcontrib>He, Qifen</creatorcontrib><creatorcontrib>You, Yingying</creatorcontrib><creatorcontrib>Fan, Yunping</creatorcontrib><creatorcontrib>Liang, Jun</creatorcontrib><title>Investigation of cancer-associated fibroblasts and p62 expression in oral cancer before and after chemotherapy</title><title>Journal of cranio-maxillo-facial surgery</title><addtitle>J Craniomaxillofac Surg</addtitle><description>The aim of this study is to investigate the expression of the autophagy protein p62 in oral squamous cell carcinoma (OSCC) cells before and after chemotherapy. We also detected cancer-associated fibroblasts (CAFs) in these OSCC samples to explore the roles of p62 and CAFs in chemotherapy.
Immunohistochemistry was used to analyze the expression of p62 and α-SMA in 26 paired OSCC samples before and after chemotherapy. The relationships between clinicopathological features, clinical outcome and the expression of these proteins were analyzed.
Our results indicated an increased stromal α-SMA expression after chemotherapy in OSCC samples. High p62 expression of OSCC cells closely correlated with stromal α-SMA expression after chemotherapy. Furthermore, the post-chemotherapy p62 expression was associated with the prognosis for OSCC patients.
These results suggest that chemotherapy may increase CAFs in OSCC. High cytoplasmic p62 expression may serve as a poor prognostic marker for OSCC patients.
•CAFs increased after chemotherapy in OSCC samples.•High p62 expression of OSCC cells correlated with stromal α-SMA expression.•The post-chemotherapy p62 expression correlated with the prognosis for OSCC patients.</description><subject>Cancer-associated fibroblasts</subject><subject>Chemotherapy</subject><subject>Dentistry</subject><subject>Oral squamous cell carcinoma</subject><subject>p62</subject><issn>1010-5182</issn><issn>1878-4119</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2018</creationdate><recordtype>article</recordtype><recordid>eNp9kMFO4zAURa0RIwoMP8ACZckmwX5JXFtigxAMSJXYMGvLsZ-pqyQOdorg78eddliysnV17pXeIeSC0YpRxq831cYMqQLKlhWDKkc_yAkTS1E2jMmj_KeMli0TsCCnKW0opZwKeUwWIJtaioadkPFpfMc0-1c9-zAWwRVGjwZjqVMKxusZbeF8F0PX6zSnQo-2mDgU-DFFTGnX8bkWdX8oFh26EPEfqN2cA7PGIcxrjHr6_EV-Ot0nPD-8Z-TPw_3L3WO5ev79dHe7Kk3d8rnsODSNboXj2iF3vAOUFriVnauldCCt7oxsBViB1EoU1giaMd3CsjFU1Gfkar87xfC2zQeqwSeDfa9HDNukgFIAoFLUGYU9amJIKaJTU_SDjp-KUbXzrDZq51ntPCsGKke5dHnY33YD2q_Kf7EZuNkDmK989xhVMh6zIOsjmlnZ4L_b_wuFYJD6</recordid><startdate>201804</startdate><enddate>201804</enddate><creator>Liang, Lizhong</creator><creator>Luo, Haiji</creator><creator>He, Qifen</creator><creator>You, Yingying</creator><creator>Fan, Yunping</creator><creator>Liang, Jun</creator><general>Elsevier Ltd</general><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>201804</creationdate><title>Investigation of cancer-associated fibroblasts and p62 expression in oral cancer before and after chemotherapy</title><author>Liang, Lizhong ; Luo, Haiji ; He, Qifen ; You, Yingying ; Fan, Yunping ; Liang, Jun</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c356t-b6244a58f6afe6f6b2e9d26d9bf399f29dabc9582d8e0d9e8dc80f6ba5274c083</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2018</creationdate><topic>Cancer-associated fibroblasts</topic><topic>Chemotherapy</topic><topic>Dentistry</topic><topic>Oral squamous cell carcinoma</topic><topic>p62</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Liang, Lizhong</creatorcontrib><creatorcontrib>Luo, Haiji</creatorcontrib><creatorcontrib>He, Qifen</creatorcontrib><creatorcontrib>You, Yingying</creatorcontrib><creatorcontrib>Fan, Yunping</creatorcontrib><creatorcontrib>Liang, Jun</creatorcontrib><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Journal of cranio-maxillo-facial surgery</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Liang, Lizhong</au><au>Luo, Haiji</au><au>He, Qifen</au><au>You, Yingying</au><au>Fan, Yunping</au><au>Liang, Jun</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Investigation of cancer-associated fibroblasts and p62 expression in oral cancer before and after chemotherapy</atitle><jtitle>Journal of cranio-maxillo-facial surgery</jtitle><addtitle>J Craniomaxillofac Surg</addtitle><date>2018-04</date><risdate>2018</risdate><volume>46</volume><issue>4</issue><spage>605</spage><epage>610</epage><pages>605-610</pages><issn>1010-5182</issn><eissn>1878-4119</eissn><abstract>The aim of this study is to investigate the expression of the autophagy protein p62 in oral squamous cell carcinoma (OSCC) cells before and after chemotherapy. We also detected cancer-associated fibroblasts (CAFs) in these OSCC samples to explore the roles of p62 and CAFs in chemotherapy.
Immunohistochemistry was used to analyze the expression of p62 and α-SMA in 26 paired OSCC samples before and after chemotherapy. The relationships between clinicopathological features, clinical outcome and the expression of these proteins were analyzed.
Our results indicated an increased stromal α-SMA expression after chemotherapy in OSCC samples. High p62 expression of OSCC cells closely correlated with stromal α-SMA expression after chemotherapy. Furthermore, the post-chemotherapy p62 expression was associated with the prognosis for OSCC patients.
These results suggest that chemotherapy may increase CAFs in OSCC. High cytoplasmic p62 expression may serve as a poor prognostic marker for OSCC patients.
•CAFs increased after chemotherapy in OSCC samples.•High p62 expression of OSCC cells correlated with stromal α-SMA expression.•The post-chemotherapy p62 expression correlated with the prognosis for OSCC patients.</abstract><cop>Scotland</cop><pub>Elsevier Ltd</pub><pmid>29439841</pmid><doi>10.1016/j.jcms.2017.12.016</doi><tpages>6</tpages></addata></record> |
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subjects | Cancer-associated fibroblasts Chemotherapy Dentistry Oral squamous cell carcinoma p62 |
title | Investigation of cancer-associated fibroblasts and p62 expression in oral cancer before and after chemotherapy |
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