FOXO Transcription Factors Both Suppress and Support Breast Cancer Progression
FOXO transcription factors are regulators of cellular homeostasis and putative tumor suppressors, yet the role of FOXO in cancer progression remains to be determined. The data on FOXO function, particularly for epithelial cancers, are fragmentary and come from studies that focused on isolated aspect...
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| Veröffentlicht in: | Cancer research (Chicago, Ill.) Ill.), 2018-05, Vol.78 (9), p.2356-2369 |
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| container_title | Cancer research (Chicago, Ill.) |
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| creator | Hornsveld, Marten Smits, Lydia M M Meerlo, Maaike van Amersfoort, Miranda Groot Koerkamp, Marian J A van Leenen, Dik Kloet, David E A Holstege, Frank C P Derksen, Patrick W B Burgering, Boudewijn M T Dansen, Tobias B |
| description | FOXO transcription factors are regulators of cellular homeostasis and putative tumor suppressors, yet the role of FOXO in cancer progression remains to be determined. The data on FOXO function, particularly for epithelial cancers, are fragmentary and come from studies that focused on isolated aspects of cancer. To clarify the role of FOXO in epithelial cancer progression, we characterized the effects of inducible FOXO activation and loss in a mouse model of metastatic invasive lobular carcinoma. Strikingly, either activation or loss of FOXO function suppressed tumor growth and metastasis. We show that the multitude of cellular processes critically affected by FOXO function include proliferation, survival, redox homeostasis, and PI3K signaling, all of which must be carefully balanced for tumor cells to thrive.
FOXO proteins are not solely tumor suppressors, but also support tumor growth and metastasis by regulating a multitude of cellular processes essential for tumorigenesis.
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| doi_str_mv | 10.1158/0008-5472.CAN-17-2511 |
| format | Article |
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FOXO proteins are not solely tumor suppressors, but also support tumor growth and metastasis by regulating a multitude of cellular processes essential for tumorigenesis.
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FOXO proteins are not solely tumor suppressors, but also support tumor growth and metastasis by regulating a multitude of cellular processes essential for tumorigenesis.
.</description><subject>1-Phosphatidylinositol 3-kinase</subject><subject>Activation</subject><subject>Breast cancer</subject><subject>Cancer</subject><subject>Forkhead protein</subject><subject>Homeostasis</subject><subject>Invasiveness</subject><subject>Metastases</subject><subject>Metastasis</subject><subject>Proteins</subject><subject>Regulators</subject><subject>Transcription factors</subject><subject>Tumor cells</subject><subject>Tumorigenesis</subject><issn>0008-5472</issn><issn>1538-7445</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2018</creationdate><recordtype>article</recordtype><recordid>eNpdkE1LAzEQhoMotlZ_grLgxcvWfM0mPbaLVaG0ghW8hXQ30ZZ2sya7B_-9WVt78DS8w_MOw4PQNcFDQkDeY4xlClzQYT6ep0SkFAg5QX0CTKaCczhF_SPTQxchbGIEguEc9eiIc0wy2Ufz6eJ9kSy9rkLh13WzdlUy1UXjfEgmrvlMXtu69iaERFflb3C-SSbe6NAkua4K45MX7z46JHYv0ZnV22CuDnOA3qYPy_wpnS0en_PxLC044Ca1ssx4RjmhKzYqodBMUGtArrgEA5ZaIjllcQmaGcooZ7aw2cjiEiTOBGMDdLe_W3v31ZrQqN06FGa71ZVxbVAUY0opBgkRvf2Hblzrq_hdpBjNiBBMRAr2VOFdCN5YVfv1TvtvRbDqhKtOpupkqihcEaE64bF3c7jernamPLb-DLMflI15rg</recordid><startdate>20180501</startdate><enddate>20180501</enddate><creator>Hornsveld, Marten</creator><creator>Smits, Lydia M M</creator><creator>Meerlo, Maaike</creator><creator>van Amersfoort, Miranda</creator><creator>Groot Koerkamp, Marian J A</creator><creator>van Leenen, Dik</creator><creator>Kloet, David E A</creator><creator>Holstege, Frank C P</creator><creator>Derksen, Patrick W B</creator><creator>Burgering, Boudewijn M T</creator><creator>Dansen, Tobias B</creator><general>American Association for Cancer Research, Inc</general><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7T5</scope><scope>7TM</scope><scope>7TO</scope><scope>7U9</scope><scope>8FD</scope><scope>FR3</scope><scope>H94</scope><scope>P64</scope><scope>RC3</scope><scope>7X8</scope></search><sort><creationdate>20180501</creationdate><title>FOXO Transcription Factors Both Suppress and Support Breast Cancer Progression</title><author>Hornsveld, Marten ; 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FOXO proteins are not solely tumor suppressors, but also support tumor growth and metastasis by regulating a multitude of cellular processes essential for tumorigenesis.
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| source | American Association for Cancer Research; EZB-FREE-00999 freely available EZB journals |
| subjects | 1-Phosphatidylinositol 3-kinase Activation Breast cancer Cancer Forkhead protein Homeostasis Invasiveness Metastases Metastasis Proteins Regulators Transcription factors Tumor cells Tumorigenesis |
| title | FOXO Transcription Factors Both Suppress and Support Breast Cancer Progression |
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