Refrigeration, cryopreservation and pathogen inactivation: an updated perspective on platelet storage conditions
Conventional storage of platelet concentrates limits their shelf life to between 5 and 7 days due to the risk of bacterial proliferation and the development of the platelet storage lesion. Cold storage and cryopreservation of platelets may facilitate extension of the shelf life to weeks and years, a...
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| Veröffentlicht in: | Vox sanguinis 2018-05, Vol.113 (4), p.317-328 |
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| container_title | Vox sanguinis |
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| creator | Waters, L. Cameron, M. Padula, M. P. Marks, D. C. Johnson, L. |
| description | Conventional storage of platelet concentrates limits their shelf life to between 5 and 7 days due to the risk of bacterial proliferation and the development of the platelet storage lesion. Cold storage and cryopreservation of platelets may facilitate extension of the shelf life to weeks and years, and may also provide the benefit of being more haemostatically effective than conventionally stored platelets. Further, treatment of platelet concentrates with pathogen inactivation systems reduces bacterial contamination and provides a safeguard against the risk of emerging and re‐emerging pathogens. While each of these alternative storage techniques is gaining traction individually, little work has been done to examine the effect of combining treatments in an effort to further improve product safety and minimize wastage. This review aims to discuss the benefits of alternative storage techniques and how they may be combined to alleviate the problems associated with conventional platelet storage. |
| doi_str_mv | 10.1111/vox.12640 |
| format | Article |
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| ispartof | Vox sanguinis, 2018-05, Vol.113 (4), p.317-328 |
| issn | 0042-9007 1423-0410 |
| language | eng |
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| source | Wiley Online Library Journals Frontfile Complete |
| subjects | cold Cold storage Contamination Cryopreservation Deactivation Health risks Inactivation pathogen inactivation Pathogens platelet Platelets Product safety Refrigeration Shelf life storage Storage conditions |
| title | Refrigeration, cryopreservation and pathogen inactivation: an updated perspective on platelet storage conditions |
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