Soliseptide A, A Cyclic Hexapeptide Possessing Piperazic Acid Groups from Streptomyces solisilvae HNM30702

Soliseptide A, A Cyclic Hexapeptide Possessing Piperazic Acid Groups from Streptomyces solisilvae HNM30702

Soliseptide A (1), a cyclic hexapeptide possessing piperazic acid groups, together with two known azalomycin derivatives (2 and 3) were isolated from Streptomyces solisilvae HNM30702. Their structures were determined through spectroscopic methods and single crystal X-ray diffraction analysis. Solise...

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Veröffentlicht in:Organic letters 2018-03, Vol.20 (5), p.1371-1374
Hauptverfasser: Wang, Junfeng, Cong, Ziwen, Huang, Xiaolong, Hou, Chenxi, Chen, Weihao, Tu, Zhengchao, Huang, Dongyi, Liu, Yonghong
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container_end_page 1374
container_issue 5
container_start_page 1371
container_title Organic letters
container_volume 20
creator Wang, Junfeng
Cong, Ziwen
Huang, Xiaolong
Hou, Chenxi
Chen, Weihao
Tu, Zhengchao
Huang, Dongyi
Liu, Yonghong
description Soliseptide A (1), a cyclic hexapeptide possessing piperazic acid groups, together with two known azalomycin derivatives (2 and 3) were isolated from Streptomyces solisilvae HNM30702. Their structures were determined through spectroscopic methods and single crystal X-ray diffraction analysis. Soliseptide A (1) possessed a cyclic hexapeptide core featured with two piperazic acid units rarely discovered in nature, and exhibited weak antibacterial and antiviral activities. Besides, compounds 2 and 3 displayed significant fungicidal effects.
doi_str_mv 10.1021/acs.orglett.8b00142
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title Soliseptide A, A Cyclic Hexapeptide Possessing Piperazic Acid Groups from Streptomyces solisilvae HNM30702
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