Cutting Edge: Check Your Mice-A Point Mutation in the Ncr1 Locus Identified in CD45.1 Congenic Mice with Consequences in Mouse Susceptibility to Infection

B6.SJL- /Boy (CD45.1) mice have been used in hundreds of congenic competitive transplants, with the presumption that they differ from C57BL/6 mice only at the CD45 locus. In this study, we describe a point mutation in the natural cytotoxicity receptor 1 ( ) locus fortuitously identified in the CD45....

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Veröffentlicht in:	The Journal of immunology (1950) 2018-03, Vol.200 (6), p.1982-1987
Hauptverfasser:	Jang, Youngsoon, Gerbec, Zachary J, Won, Taejoon, Choi, Bongkum, Podsiad, Amy, B Moore, Bethany, Malarkannan, Subramaniam, Laouar, Yasmina
Format:	Artikel
Sprache:	eng
Schlagworte:	Amino acids Animals Antigens, Ly - genetics Arginine CD45 antigen Cytotoxicity Hemagglutinins Hemagglutinins - immunology Immunity, Innate Influenza Interferon-gamma - immunology Leukocyte Common Antigens - genetics Mice Mice, Congenic Mice, Inbred C57BL Mutation Natural Cytotoxicity Triggering Receptor 1 - genetics Orthomyxoviridae - immunology Orthomyxoviridae Infections - genetics Orthomyxoviridae Infections - immunology Point mutation Point Mutation - genetics Viruses γ-Interferon
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