AT-RVD1 repairs mouse lung after cigarette smoke-induced emphysema via downregulation of oxidative stress by NRF2/KEAP1 pathway

Long-term exposure to cigarette smoke (CS) results in alveolar parenchyma destruction due to chronic inflammatory response and the imbalance between oxidants and antioxidants, and proteases and antiproteases. Emphysema is the main symptom of chronic obstructive pulmonary disease. Current treatment f...

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Veröffentlicht in:	International immunopharmacology 2018-03, Vol.56, p.330-338
Hauptverfasser:	Posso, Sara Vergel, Quesnot, Nicolas, Moraes, João Alfredo, Brito-Gitirana, Lycia, Kennedy-Feitosa, Emanuel, Barroso, Marina Valente, Porto, Luís Cristóvão, Lanzetti, Manuella, Valença, Samuel Santos
Format:	Artikel
Sprache:	eng
Schlagworte:	Alveoli Animal models Animals Anti-Inflammatory Agents - chemistry Anti-Inflammatory Agents - metabolism Antioxidants AT-RvD1 Chronic obstructive pulmonary disease Cigarette smoke Cigarette Smoking - adverse effects Cigarettes Disease Models, Animal Docosahexaenoic Acids - chemistry Docosahexaenoic Acids - metabolism Emphysema Emphysema - metabolism Fibers Humans Inflammation Inflammatory response Interleukin 10 Kelch-Like ECH-Associated Protein 1 - metabolism Leukocytes (neutrophilic) Lung diseases Lung morphology Lung repair Lungs Macrophages Maintenance Male Matrix metalloproteinases Medical treatment Mice Mice, Inbred C57BL Mouse NF-E2-Related Factor 2 - metabolism Nrf2 Obstructive lung disease Oxidants Oxidative Stress Oxidizing agents Parenchyma Peroxidase Pulmonary Disease, Chronic Obstructive - metabolism Reactive oxygen species Reactive Oxygen Species - metabolism Respiratory tract Respiratory tract diseases Rodents Signal Transduction Smoke Smoke inhalation
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