Specific Activity Features in the Forced Swim Test: Brain Neurotrophins and Development of Stress-induced Depressive-like Behavior in Rats

•BDNF expression differs in hippocampus of rats with low and high immobility in FST.•CUS increases anxiety and anhedonia in rats with low and high immobility in FST.•CUS differentially affects BDNF expression in hippocampus of rats of each type.•Behavior in FST cannot predict CUS-induced development...

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Veröffentlicht in:	Neuroscience 2018-04, Vol.375, p.49-61
Hauptverfasser:	Stepanichev, Mikhail, Manolova, Anna, Peregud, Danil, Onufriev, Mikhail, Freiman, Sofia, Aniol, Viktor, Moiseeva, Yulia, Novikova, Margarita, Lazareva, Natalia, Gulyaeva, Natalia
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Anxiety - etiology Anxiety - metabolism Brain - metabolism brain-derived neurotrophic factor Brain-Derived Neurotrophic Factor - metabolism chronic unpredictable mild stress depression Depressive Disorder - etiology Depressive Disorder - metabolism Disease Models, Animal forced swim test Gene Expression Regulation hippocampus Male nerve growth factor Nerve Growth Factor - metabolism Random Allocation Rats, Wistar Receptor, trkA - metabolism Receptor, trkB - metabolism Receptors, Nerve Growth Factor - metabolism RNA, Messenger - metabolism Stress, Psychological - complications Stress, Psychological - metabolism Swimming
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