Modulation of central endocannabinoid system results in gastric mucosal protection in the rat

•URB 597, JZL 184, inhibitors of FAAH, MAGL are gastroprotective against ethanol-lesions.•AM 404, anandamide uptake inhibitor also showed mucosal protection.•Gastroprotection developed after both central and peripheral administration in rats.•URB 937, peripherally restricted FAAH inhibitor was ineff...

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Veröffentlicht in:	Brain research bulletin 2018-05, Vol.139, p.224-234
Hauptverfasser:	Tóth, V.E., Fehér, Á., Németh, J., Gyertyán, I., Zádori, Z.S., Gyires, K.
Format:	Artikel
Sprache:	eng
Schlagworte:	Analysis of Variance Anandamide uptake blockade Animals Arachidonic Acids - pharmacology Benzamides - pharmacology Benzodioxoles - pharmacology Calcitonin Gene-Related Peptide - metabolism Carbamates - pharmacology Catalepsy - chemically induced Disease Models, Animal Dose-Response Relationship, Drug Drug Administration Routes Endocannabinoids Endocannabinoids - pharmacology Ethanol - toxicity FAAH Gastric lesion Gastric Mucosa - drug effects Gastric Mucosa - injuries Gastric Mucosa - metabolism Gastrointestinal Motility - drug effects Hypothermia - chemically induced MAGL Male Piperidines - pharmacology Rat Rats Rats, Wistar Somatostatin - metabolism Stomach Diseases - chemically induced Stomach Diseases - therapy Superoxide Dismutase - metabolism
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