MiR-146a Regulates Neutrophil Extracellular Trap Formation That Predicts Adverse Cardiovascular Events in Patients With Atrial Fibrillation

OBJECTIVE—Atrial fibrillation (AF) patients experience adverse cardiovascular events (ACEs) despite anticoagulant therapy. We reported that rs2431697 of miR-146a, a negative regulator of inflammation, predicts ACEs in patients with AF. The relationship between neutrophil extracellular traps and thro...

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Veröffentlicht in:	Arteriosclerosis, thrombosis, and vascular biology thrombosis, and vascular biology, 2018-04, Vol.38 (4), p.892-902
Hauptverfasser:	Arroyo, Ana B, de los Reyes-García, Ascensión M, Rivera-Caravaca, José M, Valledor, Patricia, García-Barberá, Nuria, Roldán, Vanessa, Vicente, Vicente, Martínez, Constantino, González-Conejero, Rocío
Format:	Artikel
Sprache:	eng
Schlagworte:	Acute Coronary Syndrome - etiology Acute Coronary Syndrome - genetics Acute Coronary Syndrome - metabolism Aged Animals Atrial Fibrillation - complications Atrial Fibrillation - genetics Atrial Fibrillation - metabolism Atrial Fibrillation - mortality Case-Control Studies Cells, Cultured Cerebrovascular Disorders - etiology Cerebrovascular Disorders - genetics Cerebrovascular Disorders - metabolism Disease Progression Extracellular Traps - genetics Extracellular Traps - metabolism Female Heart Failure - etiology Heart Failure - genetics Heart Failure - metabolism Humans Male Mice Mice, Inbred C57BL Mice, Knockout MicroRNAs - genetics MicroRNAs - metabolism Middle Aged Neutrophil Activation Neutrophils - metabolism Prognosis Risk Assessment Risk Factors Signal Transduction
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