Immunosuppressive tumor microenvironment of usual interstitial pneumonia-associated squamous cell carcinoma of the lung
Purpose Patients with usual interstitial pneumonia (UIP) often develop lung cancer. However, the biological features of lung cancer associated with UIP remain unknown. The aim of this study was to elucidate the clinicopathological characteristics of UIP-associated squamous cell carcinoma (SqCC). Met...
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| Veröffentlicht in: | Journal of cancer research and clinical oncology 2018-05, Vol.144 (5), p.835-844 |
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| creator | Ueda, Takuya Aokage, Keiju Nishikawa, Hiroyoshi Neri, Shinya Nakamura, Hiroshi Sugano, Masato Tane, Kenta Miyoshi, Tomohiro Kojima, Motohiro Fujii, Satoshi Kuwata, Takeshi Ochiai, Atsushi Kusumoto, Masahiko Suzuki, Kenji Tsuboi, Masahiro Ishii, Genichiro |
| description | Purpose
Patients with usual interstitial pneumonia (UIP) often develop lung cancer. However, the biological features of lung cancer associated with UIP remain unknown. The aim of this study was to elucidate the clinicopathological characteristics of UIP-associated squamous cell carcinoma (SqCC).
Methods
A total of 244 patients with p-stage I lung SqCC who underwent complete surgical resection were enrolled in this study. Clinicopathological differences between UIP-associated SqCC and non-UIP SqCC were examined. Moreover, we performed immunohistochemical studies to clarify the biological differences between these two groups.
Results
UIP-associated SqCC was detected in 19 patients (6.0%). Patients with UIP-associated SqCC tended to have shorter recurrence-free survival (RFS) (5-year RFS; UIP-associated SqCC 44% vs non-UIP SqCC 62%,
p
= 0.05). Immunohistochemical analysis revealed that the expression scores of cancer stem cell- and invasion-related molecules in cancer cells were not significantly different between the two groups. However, PD-L1 expression in cancer cells was significantly higher in UIP-associated SqCC (median score; 5.0 vs 0,
p
|
| doi_str_mv | 10.1007/s00432-018-2602-z |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_cross</sourceid><recordid>TN_cdi_proquest_miscellaneous_2001918179</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>2001918179</sourcerecordid><originalsourceid>FETCH-LOGICAL-c372t-eb8eb28266ba4653f35432886ef3ab569abf3940b7509eb020d99fb8f9f352cb3</originalsourceid><addsrcrecordid>eNp1kc1u1TAQhS1URC8XHoANssSmm4B_4iReoqqFSpXYwNqycyfFVWynnriIPj0Ot4CE1JU19jdnxucQ8oaz95yx_gMy1krRMD40omOieXhGdny74VKqE7JjvOeNErw7JS8Rb1mtVS9ekFOhW6l6qXbkx1UIJSYsy5IB0d8DXUtImQY_5gTx3ucUA8SVpokWLHamPq6QcfWrr8USoeLR28YiptHbFQ4U74oNqSAdYZ7paPPoYwp2k1i_A51LvHlFnk92Rnj9eO7Jt8uLr-efm-svn67OP143o-zF2oAbwIlBdJ2zbafkJFX93zB0MEnrVKetm6RumesV0-CYYAetJzdMupJidHJPzo66S053BXA1weO2lo1QNzSimqL5wHtd0Xf_obep5Fi3-00p1rLq2Z7wI1XtQcwwmSX7YPNPw5nZUjHHVExNxWypmIfa8_ZRubgAh78df2KogDgCWJ_iDeR_o59W_QWynZrz</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>2001504057</pqid></control><display><type>article</type><title>Immunosuppressive tumor microenvironment of usual interstitial pneumonia-associated squamous cell carcinoma of the lung</title><source>Springer Nature - Complete Springer Journals</source><creator>Ueda, Takuya ; Aokage, Keiju ; Nishikawa, Hiroyoshi ; Neri, Shinya ; Nakamura, Hiroshi ; Sugano, Masato ; Tane, Kenta ; Miyoshi, Tomohiro ; Kojima, Motohiro ; Fujii, Satoshi ; Kuwata, Takeshi ; Ochiai, Atsushi ; Kusumoto, Masahiko ; Suzuki, Kenji ; Tsuboi, Masahiro ; Ishii, Genichiro</creator><creatorcontrib>Ueda, Takuya ; Aokage, Keiju ; Nishikawa, Hiroyoshi ; Neri, Shinya ; Nakamura, Hiroshi ; Sugano, Masato ; Tane, Kenta ; Miyoshi, Tomohiro ; Kojima, Motohiro ; Fujii, Satoshi ; Kuwata, Takeshi ; Ochiai, Atsushi ; Kusumoto, Masahiko ; Suzuki, Kenji ; Tsuboi, Masahiro ; Ishii, Genichiro</creatorcontrib><description>Purpose
Patients with usual interstitial pneumonia (UIP) often develop lung cancer. However, the biological features of lung cancer associated with UIP remain unknown. The aim of this study was to elucidate the clinicopathological characteristics of UIP-associated squamous cell carcinoma (SqCC).
Methods
A total of 244 patients with p-stage I lung SqCC who underwent complete surgical resection were enrolled in this study. Clinicopathological differences between UIP-associated SqCC and non-UIP SqCC were examined. Moreover, we performed immunohistochemical studies to clarify the biological differences between these two groups.
Results
UIP-associated SqCC was detected in 19 patients (6.0%). Patients with UIP-associated SqCC tended to have shorter recurrence-free survival (RFS) (5-year RFS; UIP-associated SqCC 44% vs non-UIP SqCC 62%,
p
= 0.05). Immunohistochemical analysis revealed that the expression scores of cancer stem cell- and invasion-related molecules in cancer cells were not significantly different between the two groups. However, PD-L1 expression in cancer cells was significantly higher in UIP-associated SqCC (median score; 5.0 vs 0,
p
< 0.01). In the stroma of UIP-associated SqCC, the number of Foxp3
+
tumor-infiltrating lymphocytes was significantly higher than that in non-UIP SqCC (median number 43/HPF vs 24/HPF,
p
< 0.01). In addition, CD8
+
/Foxp3
+
T-cell ratio in UIP-associated SqCC was significantly lower than that in non-UIP SqCC (median ratio 1.8 vs 3.4,
p
< 0.01).
Conclusion
Our current study clearly revealed that the establishment of an immunosuppressive tumor microenvironment is a characteristic feature of UIP-associated SqCC, which can be correlated with poor prognosis in UIP-associated SqCC.</description><identifier>ISSN: 0171-5216</identifier><identifier>EISSN: 1432-1335</identifier><identifier>DOI: 10.1007/s00432-018-2602-z</identifier><identifier>PMID: 29435735</identifier><language>eng</language><publisher>Berlin/Heidelberg: Springer Berlin Heidelberg</publisher><subject>Cancer Research ; CD8 antigen ; Foxp3 protein ; Hematology ; Immunosuppression ; Internal Medicine ; Lung cancer ; Lung carcinoma ; Lymphocytes ; Lymphocytes T ; Medical prognosis ; Medicine ; Medicine & Public Health ; Oncology ; Original Article – Cancer Research ; PD-L1 protein ; Pneumonia ; Squamous cell carcinoma ; Stem cells ; Stroma ; Tumor-infiltrating lymphocytes</subject><ispartof>Journal of cancer research and clinical oncology, 2018-05, Vol.144 (5), p.835-844</ispartof><rights>Springer-Verlag GmbH Germany, part of Springer Nature 2018</rights><rights>Journal of Cancer Research and Clinical Oncology is a copyright of Springer, (2018). All Rights Reserved.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c372t-eb8eb28266ba4653f35432886ef3ab569abf3940b7509eb020d99fb8f9f352cb3</citedby><cites>FETCH-LOGICAL-c372t-eb8eb28266ba4653f35432886ef3ab569abf3940b7509eb020d99fb8f9f352cb3</cites><orcidid>0000-0001-8637-3323</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://link.springer.com/content/pdf/10.1007/s00432-018-2602-z$$EPDF$$P50$$Gspringer$$H</linktopdf><linktohtml>$$Uhttps://link.springer.com/10.1007/s00432-018-2602-z$$EHTML$$P50$$Gspringer$$H</linktohtml><link.rule.ids>314,776,780,27903,27904,41467,42536,51297</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/29435735$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Ueda, Takuya</creatorcontrib><creatorcontrib>Aokage, Keiju</creatorcontrib><creatorcontrib>Nishikawa, Hiroyoshi</creatorcontrib><creatorcontrib>Neri, Shinya</creatorcontrib><creatorcontrib>Nakamura, Hiroshi</creatorcontrib><creatorcontrib>Sugano, Masato</creatorcontrib><creatorcontrib>Tane, Kenta</creatorcontrib><creatorcontrib>Miyoshi, Tomohiro</creatorcontrib><creatorcontrib>Kojima, Motohiro</creatorcontrib><creatorcontrib>Fujii, Satoshi</creatorcontrib><creatorcontrib>Kuwata, Takeshi</creatorcontrib><creatorcontrib>Ochiai, Atsushi</creatorcontrib><creatorcontrib>Kusumoto, Masahiko</creatorcontrib><creatorcontrib>Suzuki, Kenji</creatorcontrib><creatorcontrib>Tsuboi, Masahiro</creatorcontrib><creatorcontrib>Ishii, Genichiro</creatorcontrib><title>Immunosuppressive tumor microenvironment of usual interstitial pneumonia-associated squamous cell carcinoma of the lung</title><title>Journal of cancer research and clinical oncology</title><addtitle>J Cancer Res Clin Oncol</addtitle><addtitle>J Cancer Res Clin Oncol</addtitle><description>Purpose
Patients with usual interstitial pneumonia (UIP) often develop lung cancer. However, the biological features of lung cancer associated with UIP remain unknown. The aim of this study was to elucidate the clinicopathological characteristics of UIP-associated squamous cell carcinoma (SqCC).
Methods
A total of 244 patients with p-stage I lung SqCC who underwent complete surgical resection were enrolled in this study. Clinicopathological differences between UIP-associated SqCC and non-UIP SqCC were examined. Moreover, we performed immunohistochemical studies to clarify the biological differences between these two groups.
Results
UIP-associated SqCC was detected in 19 patients (6.0%). Patients with UIP-associated SqCC tended to have shorter recurrence-free survival (RFS) (5-year RFS; UIP-associated SqCC 44% vs non-UIP SqCC 62%,
p
= 0.05). Immunohistochemical analysis revealed that the expression scores of cancer stem cell- and invasion-related molecules in cancer cells were not significantly different between the two groups. However, PD-L1 expression in cancer cells was significantly higher in UIP-associated SqCC (median score; 5.0 vs 0,
p
< 0.01). In the stroma of UIP-associated SqCC, the number of Foxp3
+
tumor-infiltrating lymphocytes was significantly higher than that in non-UIP SqCC (median number 43/HPF vs 24/HPF,
p
< 0.01). In addition, CD8
+
/Foxp3
+
T-cell ratio in UIP-associated SqCC was significantly lower than that in non-UIP SqCC (median ratio 1.8 vs 3.4,
p
< 0.01).
Conclusion
Our current study clearly revealed that the establishment of an immunosuppressive tumor microenvironment is a characteristic feature of UIP-associated SqCC, which can be correlated with poor prognosis in UIP-associated SqCC.</description><subject>Cancer Research</subject><subject>CD8 antigen</subject><subject>Foxp3 protein</subject><subject>Hematology</subject><subject>Immunosuppression</subject><subject>Internal Medicine</subject><subject>Lung cancer</subject><subject>Lung carcinoma</subject><subject>Lymphocytes</subject><subject>Lymphocytes T</subject><subject>Medical prognosis</subject><subject>Medicine</subject><subject>Medicine & Public Health</subject><subject>Oncology</subject><subject>Original Article – Cancer Research</subject><subject>PD-L1 protein</subject><subject>Pneumonia</subject><subject>Squamous cell carcinoma</subject><subject>Stem cells</subject><subject>Stroma</subject><subject>Tumor-infiltrating lymphocytes</subject><issn>0171-5216</issn><issn>1432-1335</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2018</creationdate><recordtype>article</recordtype><sourceid>8G5</sourceid><sourceid>ABUWG</sourceid><sourceid>AFKRA</sourceid><sourceid>AZQEC</sourceid><sourceid>BENPR</sourceid><sourceid>CCPQU</sourceid><sourceid>DWQXO</sourceid><sourceid>GNUQQ</sourceid><sourceid>GUQSH</sourceid><sourceid>M2O</sourceid><recordid>eNp1kc1u1TAQhS1URC8XHoANssSmm4B_4iReoqqFSpXYwNqycyfFVWynnriIPj0Ot4CE1JU19jdnxucQ8oaz95yx_gMy1krRMD40omOieXhGdny74VKqE7JjvOeNErw7JS8Rb1mtVS9ekFOhW6l6qXbkx1UIJSYsy5IB0d8DXUtImQY_5gTx3ucUA8SVpokWLHamPq6QcfWrr8USoeLR28YiptHbFQ4U74oNqSAdYZ7paPPoYwp2k1i_A51LvHlFnk92Rnj9eO7Jt8uLr-efm-svn67OP143o-zF2oAbwIlBdJ2zbafkJFX93zB0MEnrVKetm6RumesV0-CYYAetJzdMupJidHJPzo66S053BXA1weO2lo1QNzSimqL5wHtd0Xf_obep5Fi3-00p1rLq2Z7wI1XtQcwwmSX7YPNPw5nZUjHHVExNxWypmIfa8_ZRubgAh78df2KogDgCWJ_iDeR_o59W_QWynZrz</recordid><startdate>20180501</startdate><enddate>20180501</enddate><creator>Ueda, Takuya</creator><creator>Aokage, Keiju</creator><creator>Nishikawa, Hiroyoshi</creator><creator>Neri, Shinya</creator><creator>Nakamura, Hiroshi</creator><creator>Sugano, Masato</creator><creator>Tane, Kenta</creator><creator>Miyoshi, Tomohiro</creator><creator>Kojima, Motohiro</creator><creator>Fujii, Satoshi</creator><creator>Kuwata, Takeshi</creator><creator>Ochiai, Atsushi</creator><creator>Kusumoto, Masahiko</creator><creator>Suzuki, Kenji</creator><creator>Tsuboi, Masahiro</creator><creator>Ishii, Genichiro</creator><general>Springer Berlin Heidelberg</general><general>Springer Nature B.V</general><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7TO</scope><scope>7X7</scope><scope>7XB</scope><scope>88E</scope><scope>8AO</scope><scope>8C1</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>8G5</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>AZQEC</scope><scope>BENPR</scope><scope>CCPQU</scope><scope>DWQXO</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>GNUQQ</scope><scope>GUQSH</scope><scope>H94</scope><scope>K9.</scope><scope>M0S</scope><scope>M1P</scope><scope>M2O</scope><scope>MBDVC</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PRINS</scope><scope>Q9U</scope><scope>7X8</scope><orcidid>https://orcid.org/0000-0001-8637-3323</orcidid></search><sort><creationdate>20180501</creationdate><title>Immunosuppressive tumor microenvironment of usual interstitial pneumonia-associated squamous cell carcinoma of the lung</title><author>Ueda, Takuya ; Aokage, Keiju ; Nishikawa, Hiroyoshi ; Neri, Shinya ; Nakamura, Hiroshi ; Sugano, Masato ; Tane, Kenta ; Miyoshi, Tomohiro ; Kojima, Motohiro ; Fujii, Satoshi ; Kuwata, Takeshi ; Ochiai, Atsushi ; Kusumoto, Masahiko ; Suzuki, Kenji ; Tsuboi, Masahiro ; Ishii, Genichiro</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c372t-eb8eb28266ba4653f35432886ef3ab569abf3940b7509eb020d99fb8f9f352cb3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2018</creationdate><topic>Cancer Research</topic><topic>CD8 antigen</topic><topic>Foxp3 protein</topic><topic>Hematology</topic><topic>Immunosuppression</topic><topic>Internal Medicine</topic><topic>Lung cancer</topic><topic>Lung carcinoma</topic><topic>Lymphocytes</topic><topic>Lymphocytes T</topic><topic>Medical prognosis</topic><topic>Medicine</topic><topic>Medicine & Public Health</topic><topic>Oncology</topic><topic>Original Article – Cancer Research</topic><topic>PD-L1 protein</topic><topic>Pneumonia</topic><topic>Squamous cell carcinoma</topic><topic>Stem cells</topic><topic>Stroma</topic><topic>Tumor-infiltrating lymphocytes</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Ueda, Takuya</creatorcontrib><creatorcontrib>Aokage, Keiju</creatorcontrib><creatorcontrib>Nishikawa, Hiroyoshi</creatorcontrib><creatorcontrib>Neri, Shinya</creatorcontrib><creatorcontrib>Nakamura, Hiroshi</creatorcontrib><creatorcontrib>Sugano, Masato</creatorcontrib><creatorcontrib>Tane, Kenta</creatorcontrib><creatorcontrib>Miyoshi, Tomohiro</creatorcontrib><creatorcontrib>Kojima, Motohiro</creatorcontrib><creatorcontrib>Fujii, Satoshi</creatorcontrib><creatorcontrib>Kuwata, Takeshi</creatorcontrib><creatorcontrib>Ochiai, Atsushi</creatorcontrib><creatorcontrib>Kusumoto, Masahiko</creatorcontrib><creatorcontrib>Suzuki, Kenji</creatorcontrib><creatorcontrib>Tsuboi, Masahiro</creatorcontrib><creatorcontrib>Ishii, Genichiro</creatorcontrib><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Central (Corporate)</collection><collection>Oncogenes and Growth Factors Abstracts</collection><collection>Health & Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Medical Database (Alumni Edition)</collection><collection>ProQuest Pharma Collection</collection><collection>Public Health Database</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>Research Library (Alumni Edition)</collection><collection>ProQuest Central (Alumni Edition)</collection><collection>ProQuest Central UK/Ireland</collection><collection>ProQuest Central Essentials</collection><collection>ProQuest Central</collection><collection>ProQuest One Community 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oncology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Ueda, Takuya</au><au>Aokage, Keiju</au><au>Nishikawa, Hiroyoshi</au><au>Neri, Shinya</au><au>Nakamura, Hiroshi</au><au>Sugano, Masato</au><au>Tane, Kenta</au><au>Miyoshi, Tomohiro</au><au>Kojima, Motohiro</au><au>Fujii, Satoshi</au><au>Kuwata, Takeshi</au><au>Ochiai, Atsushi</au><au>Kusumoto, Masahiko</au><au>Suzuki, Kenji</au><au>Tsuboi, Masahiro</au><au>Ishii, Genichiro</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Immunosuppressive tumor microenvironment of usual interstitial pneumonia-associated squamous cell carcinoma of the lung</atitle><jtitle>Journal of cancer research and clinical oncology</jtitle><stitle>J Cancer Res Clin Oncol</stitle><addtitle>J Cancer Res Clin Oncol</addtitle><date>2018-05-01</date><risdate>2018</risdate><volume>144</volume><issue>5</issue><spage>835</spage><epage>844</epage><pages>835-844</pages><issn>0171-5216</issn><eissn>1432-1335</eissn><abstract>Purpose
Patients with usual interstitial pneumonia (UIP) often develop lung cancer. However, the biological features of lung cancer associated with UIP remain unknown. The aim of this study was to elucidate the clinicopathological characteristics of UIP-associated squamous cell carcinoma (SqCC).
Methods
A total of 244 patients with p-stage I lung SqCC who underwent complete surgical resection were enrolled in this study. Clinicopathological differences between UIP-associated SqCC and non-UIP SqCC were examined. Moreover, we performed immunohistochemical studies to clarify the biological differences between these two groups.
Results
UIP-associated SqCC was detected in 19 patients (6.0%). Patients with UIP-associated SqCC tended to have shorter recurrence-free survival (RFS) (5-year RFS; UIP-associated SqCC 44% vs non-UIP SqCC 62%,
p
= 0.05). Immunohistochemical analysis revealed that the expression scores of cancer stem cell- and invasion-related molecules in cancer cells were not significantly different between the two groups. However, PD-L1 expression in cancer cells was significantly higher in UIP-associated SqCC (median score; 5.0 vs 0,
p
< 0.01). In the stroma of UIP-associated SqCC, the number of Foxp3
+
tumor-infiltrating lymphocytes was significantly higher than that in non-UIP SqCC (median number 43/HPF vs 24/HPF,
p
< 0.01). In addition, CD8
+
/Foxp3
+
T-cell ratio in UIP-associated SqCC was significantly lower than that in non-UIP SqCC (median ratio 1.8 vs 3.4,
p
< 0.01).
Conclusion
Our current study clearly revealed that the establishment of an immunosuppressive tumor microenvironment is a characteristic feature of UIP-associated SqCC, which can be correlated with poor prognosis in UIP-associated SqCC.</abstract><cop>Berlin/Heidelberg</cop><pub>Springer Berlin Heidelberg</pub><pmid>29435735</pmid><doi>10.1007/s00432-018-2602-z</doi><tpages>10</tpages><orcidid>https://orcid.org/0000-0001-8637-3323</orcidid></addata></record> |
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| ispartof | Journal of cancer research and clinical oncology, 2018-05, Vol.144 (5), p.835-844 |
| issn | 0171-5216 1432-1335 |
| language | eng |
| recordid | cdi_proquest_miscellaneous_2001918179 |
| source | Springer Nature - Complete Springer Journals |
| subjects | Cancer Research CD8 antigen Foxp3 protein Hematology Immunosuppression Internal Medicine Lung cancer Lung carcinoma Lymphocytes Lymphocytes T Medical prognosis Medicine Medicine & Public Health Oncology Original Article – Cancer Research PD-L1 protein Pneumonia Squamous cell carcinoma Stem cells Stroma Tumor-infiltrating lymphocytes |
| title | Immunosuppressive tumor microenvironment of usual interstitial pneumonia-associated squamous cell carcinoma of the lung |
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