Bisphosphonates activate the 5-fluorouracil/uracil phosphoribosyltransferase activity present in Saccharomyces cerevisiae cell extracts Implications for tumor treatments

Most of the effects described for bisphosphonates (pC(R1)(R2)p) are related, directly or indirectly with a pyrophosphate moiety. Bisphosphonates are (i) analogs of pyrophosphate in the synthesis of ATP derivatives (AppC(R1)(R2)p) catalyzed by ligases and (ii) inhibitors of enzymes of the mevalonate...

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Veröffentlicht in:	Biochemical pharmacology 2008-10, Vol.76 (7), p.825-830
Hauptverfasser:	PEREZ-ZUNIGA, Francisco J, GÜNTHER SILLERO, Maria A, SILLERO, Antonio
Format:	Artikel
Sprache:	eng
Schlagworte:	Antimetabolites, Antineoplastic - pharmacology Biological and medical sciences Bone Density Conservation Agents - pharmacology Diphosphonates - pharmacology Diseases of the osteoarticular system Fluorouracil - pharmacology Medical sciences Neoplasms - drug therapy Osteoporosis. Osteomalacia. Paget disease Pentosyltransferases - metabolism Pharmacology. Drug treatments Saccharomyces cerevisiae Saccharomyces cerevisiae - drug effects Saccharomyces cerevisiae - enzymology Uracil - pharmacology
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